Results 51 to 60 of about 29,480 (254)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The Best Way of Preserving Something is to Educate about it - Educational Centres in South Africa

open access: yesEXARC Journal, 2016
This article aims to show the kind of issues South- African archaeologists have, working with public archaeology. A past that was segregated earlier should now be shared, but sharing a common past includes alternative perspectives on history and ...
Frauke Sontberg
doaj  

Breathing Life Sustainably - An Abandoned Settlement to an Open-Air Museum Twah Longwar

open access: yesEXARC Journal, 2023
Twah Longwar is an abandoned settlement located in the State of Meghalaya in North-East India. It is located enroute to one of the world's rainiest places on earth – Mawsynram.
Naphibahun Lyngdoh
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Replication of a Maori Ethnographic Textile Hem Border Pattern

open access: yesEXARC Journal, 2019
Replication of archaeological and ethnographic Māori textiles, under the direction of customary knowledge and previous practical experience, can provide a more nuanced understanding of the manufacture of taonga (treasures) made from fibre materials.
Lisa McKendry
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Variables and Assumptions in Modern Interpretation of Ancient Spinning Technique and Technology Through Archaeological Experimentation

open access: yesEXARC Journal, 2014
This paper takes the form of a critical analysis of archaeological experiments using spinning tools. The archaeological experiments regarding whorl weight and wool spinning of the Tools and Textiles – Texts and Contexts project, through the Danish ...
Tracy P. Hudson
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Event Review: Biannual Conference of the Association of European Open Air Museums (AEOM), Poland, August 2019

open access: yesEXARC Journal, 2019
This year’s Association of European Open Air Museums (AEOM) Biannual Conference 2019 took place at multiple sites in Poland, over four days in late August.
Peter Inker
doaj  

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