Results 61 to 70 of about 29,480 (254)

Killing the Cauldron: Experimental Research on Dented Bronze Cauldrons from the (post)Medieval Period

open access: yesEXARC Journal, 2021
Bronze cauldrons from the late Middle Ages, and the 16th and 17th century are hardly ever discovered during archaeological excavations but are usually unearthed by detectorists having discovered the find of their life.
Vincent van Vilsteren
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Shifting the Sand: Replicating Black Powder Grenades

open access: yesEXARC Journal, 2018
Black powder hand grenades are ubiquitous for several European archaeological sites between 1600 AD and 1900 AD. Unfortunately, many archaeological reports only note the presence of hand grenades in artifact inventories, perhaps denoting some minor ...
Stephen Lacey
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

120 Years of Strategies and Experiences in Educational and Handicraft Skills

open access: yesEXARC Journal, 2013
Report on a Study-visit to Skansen Open-Air Museum,Stockholm / Sweden, Summer 2013. One aim of the five year EU-funded Culture Project OpenArch is to encourage cooperation between archaeological open-air museums in Europe and ethnological open-air ...
Rüdiger Kelm
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Certain Small Contrivances. Recreating an Intestinal Condom Recipe to Determine the Potential Effects of Manufacturing on Zooarchaeology by Mass Spectrometry (ZooMS)

open access: yesEXARC Journal
Skin and membranous artifacts are rarely recovered from archaeological excavations due to taphonomic processes that result in rapid decomposition.
Elizabeth G. Tarulis   +2 more
doaj  

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