Results 91 to 100 of about 1,963,105 (289)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Media: Tauiwi and Māori news: The indigenous view
Pacific Journalism Review, 1996 Aotearoa/New Zealand is divided between the mainstream news media and the fast-gowing Māori media with different perspectives. New Zealand journalism graduates need to be taught different media systems and news values.
Ian Stuart
doaj +1 more source
Politics, terrorism and the news media: a case study of Saudi Arabia (2006-2007). [PDF]
With the enormous development of communications and the transmission of national news to all parts of the world in seconds, it has become important to consider the treatment of national crises in the media and the challenges that may be encountered in ...
Al-Khalifa, Khuldiya Mohamed
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
News Won’t Find Me? Exploring Inequalities in Social Media News Use With Tracking Data
International Journal of Communication, 2022 The rise of news content on social media has been accompanied by a hope that people with lower socioeconomic status and less interest in political affairs would be “accidentally” exposed to news.
Lisa Merten +4 more
doaj +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Vestnik Bishkek state university af K KarasaevThis article explores the essence and economic content of the modern media market, emphasizing the global emergence of new media. It defines new media, contrasts it with traditional outlets such as television, radio, and newspapers, and structures its main features, including its advantages and disadvantages.
openaire +1 more source
Audience responses to news media images of Pacific health [PDF]
, 2008 News media contain a multitude of images of Pacific peoples and health. This paper presents findings from a social psychological study of audience responses to such images.
Loto, Robert
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source