Results 101 to 110 of about 19,825,415 (296)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Transformation and transcendence – reforming news production in the convergent media era
Trans/Form/AçãoThe present-day networked media ecosystem is distinctly characterized by convergence. Recently, media convergence has experienced rapidly progress both in theoretical circles and in practical applications, and convergence development has inevitably ...
Zhi Li, Yinchang Chen
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Contextualization: A Path to Chinese Traditional News Media’s Integration Into Social Media
Media and CommunicationMeyrowitz’s media context theory proposes that new media and their contexts will lead to new behaviors. This article adopts media context theory as a framework and utilizes a textual analysis approach to analyze what Meyrowitz termed middle region ...
Difan Guo, Haiyan Wang, Jinghong Xu
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Māori and community news constructions of Meningococcal B: the promotion of a moral obligation to vaccinate [PDF]
, 2007 News media communicate various risks of disease, showcase medical breakthroughs and disseminate texts that both reflect and renegotiate shared cultural understandings of health and illness. Little is known about the role of Māori and community news media
Groot, Shiloh Ann Maree +5 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
New Media, Legacy Media and Misperceptions Regarding Sourcing [PDF]
KOME: An International Journal of Pure Communication Inquiry, 2017 Resource dependence theory and related theories of management suggest online-only news media may displace legacy news media, but until that happens the two systems are likely to be dependent on the same resource: news.
Stan Diel
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source