Results 91 to 100 of about 19,825,415 (296)
New Media, Old News: journalism and democracy in the digital age (Book review)
, 2011 New Media, Old News: journalism and democracy in the digital age, Natalie Fenton (Ed.), London: Sage, 2010, 220 pp. ISBN 978-1-84787-574-
Dekavalla, Marina
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
“Seeing but not Believing”: Undergraduate Students’ Media Uses and News Trust
International Journal of Communication, 2023 Young people often encounter the news on social media while engaging in social and entertainment practices. Despite relying on social media for news, youth see online information with suspicion and as less trustworthy than traditional news media.
Ana Isabel Melro, Sara Pereira
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oklahoma's news media ecosystem Phase II research: Status and suggestions for local news
, 2023 Access to reliable local news is an essential component of civic life. Particularly in rural communities, local news provides information and promotes community engagement. Despite the importance of local news, data on the status of access and quality of
Avance, Rosemary, Shortle, Allyson
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
News Won’t Find Me? Exploring Inequalities in Social Media News Use With Tracking Data
International Journal of Communication, 2022 The rise of news content on social media has been accompanied by a hope that people with lower socioeconomic status and less interest in political affairs would be “accidentally” exposed to news.
Lisa Merten +4 more
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