Results 91 to 100 of about 1,973,449 (292)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Comunicação e SociedadeDigitalization has led to a crisis in news media and an upheaval in media ownership. A research concern has been that the motives driving media owners will shift from financial and public service to overtly political and ideological.
Mark Blach-Ørsten +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Italy in the Australian news media, 2005-2012 [PDF]
, 2013 Presents a systematic analysis of the coverage of Italian matters in the Australian news media in the period 2005-2012. Executive summary The study presents a systematic analysis of the coverage of Italian matters in the Australian news media in the ...
Franco Papandrea +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Vestnik Bishkek state university af K KarasaevThis article explores the essence and economic content of the modern media market, emphasizing the global emergence of new media. It defines new media, contrasts it with traditional outlets such as television, radio, and newspapers, and structures its main features, including its advantages and disadvantages.
openaire +1 more source
Pre-Primary News Coverage of the 2016 Presidential Race: Trump's Rise, Sanders' Emergence, Clinton's Struggle [PDF]
, 2016 A new report from Harvard Kennedy School's Shorenstein Center on Media, Politics and Public Policy analyzes news coverage of the 2016 presidential candidates in the year leading up to the primaries. This crucial period, labeled "the invisible primary" by
Thomas E. Patterson
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
“Seeing but not Believing”: Undergraduate Students’ Media Uses and News Trust
International Journal of Communication, 2023 Young people often encounter the news on social media while engaging in social and entertainment practices. Despite relying on social media for news, youth see online information with suspicion and as less trustworthy than traditional news media.
Ana Isabel Melro, Sara Pereira
doaj
This paper investigates how competition in the media affects the quality of news. In our model, demand for news depends on the market perception of the media's ability to receive correct information: it is positive if and only if news is potentially ...
Elena Panova
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