Results 111 to 120 of about 3,662,984 (294)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
U.S. News Outlets - Network of Shared Topics [PDF]
Journal of Social Structure, 2010 Katherine Ognyanova
doaj +1 more source
InformationTopic modeling of large news streams is widely used to reconstruct economic and political narratives, which requires coherent topics with low lexical overlap while remaining interpretable to domain experts.
Dmitriy Rodionov +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
, 2011 New material for the Digitalily lecture. Topics include: online disinhibition effect, anonymous in the news, NPR expose, the Year in Crazy, 2010 by Tom Tomorrow, social news, and Arrivederci APC.... Welcome back VIA!Obama's Birth Certificate --Birthcert.
Stony Brook University. School of Journalism. Center for News Literacy.
core
i-JEN: Visual interactive Malaysia crime news retrieval system [PDF]
, 2011 Supporting crime news investigation involves a mechanism to help monitor the current and past status of criminal events. We believe this could be well facilitated by focusing on the user interfaces and the event crime model aspects.
Crestani, Fabio +5 more
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Chicago Summer Institute 2012 - The Future of News
, 2010 A PowerPoint presentation for the lesson "The Future of News." Topics include: your responsibilities, opinion, advertising, the future of newsrooms, the future of news reporting, future roles for the news consumer, crowd sourcing, verification ...
Stony Brook University. School of Journalism. Center for News Literacy.
core