Results 81 to 90 of about 963,855 (274)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genetic landscape and clinical outcomes of autosomal recessive polycystic kidney disease in Kuwait

Heliyon
Background: Autosomal recessive polycystic kidney disease (ARPKD), a rare genetic disorder characterized by kidney cysts, shows complex clinical and genetic heterogeneity.
Mariam E. Alhaddad, Anwar Mohammad, Khadija M. Dashti, Sumi Elsa John, Yousif Bahbahani, Mohamed Abu-Farha, Jehad Abubaker, Thangavel Alphonse Thanaraj, Laila Bastaki, Fahd Al-Mulla, Mohammad Al-Ali, Hamad Ali   +11 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Whole genome molecular analysis of respiratory syncytial virus pre and during the COVID-19 pandemic in Free State province, South Africa

Virus Research
Respiratory syncytial virus (RSV) is the most predominant viral pathogen worldwide in children with lower respiratory tract infections. The Coronavirus disease 2019 (COVID-19) pandemic and resulting nonpharmaceutical interventions perturbed the ...
Hlengiwe Sondlane, Ayodeji Ogunbayo, Celeste Donato, Milton Mogotsi, Mathew Esona, Ute Hallbauer, Phillip Bester, Dominique Goedhals, Martin Nyaga   +8 more
doaj   +1 more source

Whole Genome In-Silico Analysis of South African G1P[8] Rotavirus Strains before and after Vaccine Introduction over a Period of 14 Years

Vaccines, 2020
Rotavirus G1P[8] strains account for more than half of the group A rotavirus (RVA) infections in children under five years of age, globally. A total of 103 stool samples previously characterized as G1P[8] and collected seven years before and seven years ...
Peter N. Mwangi, Milton T. Mogotsi, Mapaseka L. Seheri, M. Jeffrey Mphahlele, Ina Peenze, Mathew D. Esona, Benjamin Kumwenda, A. Duncan Steele, Carl D. Kirkwood, Valantine N. Ndze, Francis E. Dennis, Khuzwayo C. Jere, Martin M. Nyaga   +12 more
doaj   +1 more source

Length distribution of sequencing by synthesis: fixed flow cycle model

, 2014
Sequencing by synthesis is the underlying technology for many next-generation DNA sequencing platforms. We developed a new model, the fixed flow cycle model, to derive the distributions of sequence length for a given number of flow cycles under the ...
Kong, Yong
core   +1 more source

Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing [PDF]

, 2012
We propose a flexible change-point model for inhomogeneous Poisson Processes, which arise naturally from next-generation DNA sequencing, and derive score and generalized likelihood statistics for shifts in intensity functions.
Shen, Jeremy J., Zhang, Nancy R.
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Corrigendum to “Whole genome molecular analysis of respiratory syncytial virus pre and during the COVID-19 pandemic in Free State province, South Africa” [Virus Research, Volume 347, September 2024, 199421]

Virus Research
Respiratory syncytial virus (RSV) is the most predominant viral pathogen worldwide in children with lower respiratory tract infections. The coronavirus disease 2019 (COVID-19) pandemic and resulting non-pharmaceutical interventions perturbed the ...
Hlengiwe Sondlane, Ayodeji Ogunbayo, Celeste Donato, Milton Mogotsi, Mathew Esona, Ute Hallbauer, Phillip Bester, Dominique Goedhals, Martin Nyaga   +8 more
doaj   +1 more source

Parallelization of Mapping Algorithms for Next Generation Sequencing Applications [PDF]

, 2009
With the advent of next-generation high throughput sequencing instruments, large volumes of short sequence data are generated at an unprecedented rate. Processing and analyzing these massive data requires overcoming several challenges.
Barbacioru, Catalin C., Bozdag, Doruk, Catalyurek, Umit V.   +2 more
core   +1 more source