Results 121 to 130 of about 599,996 (240)

Immunofluroscence of phosphorylated p65-NF-κB expression in hPVECs and VK2/E6E7 cells.

, 2017
hPVECs (A) and VK2/E6E7 (B) cells were treated with LPS (10 μg/ml 6 hrs) or Bay 11–7082 (5 μM for 24 hrs). Stimulation with LPS activates p65-NF-κB expression in hPVECs (b,e) and VK2/E6E7 cells (h,k) as compared to unstimulated hPVECs (a,d) and VK2/E6E7 ...
Debarchana Saha (3727411), Mandar Patgaonkar (730628), Kudumula Venkata Rami Reddy (506311), Swanand Koli (3727414)   +3 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

NF-κB is a central regulator of hypoxia-induced gene expression

EMBO Reports
Hypoxia is both a physiological and pathological signal in cells. Changes in gene expression play a critical role in the cellular response to hypoxia, enabling cells to adapt to reduced oxygen availability. These changes are primarily mediated by the HIF
Dilem Shakir, Michael Batie, Chun-Sui Kwok, Simon J Cook, Niall S Kenneth, Sonia Rocha   +5 more
doaj   +1 more source

Effects of hGAG on NF-κB signaling.

, 2013
(A) hGAG treatment shows no effect on the expression of NF-κB(p65), NF-κB(p50) and its inhibitor IκBα in B16F10 tumor cells. Data are represented as mean ± S.E. from 3–5 independent experiments.
Yang Zhao (39052), Xiang Gao (4077), Zhijie Zhu (381047), Shizhong Zheng (381048), Yin Lu (381049), Sheng Wang (339979), Daohai Zhang (79470), Aiyun Wang (381046), Li Tao (154250), Wenxing Chen (352859)   +9 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

A Nuclear Inhibitor of NF-κB Encoded by a Poxvirus

, 2011
Poxviruses have evolved various strategies to inhibit cytoplasmic events leading to activation of the nuclear factor κB (NF-κB) signaling pathway, with individual viruses often encoding multiple NF-κB inhibitors.
G. Delhon, S. Luo, Y. Peng, D. L. Rock, E. F. Flores, D. G. Diel   +5 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

1,8-cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity.

, 2013
Greiner J, Müller J, Zeuner M, et al. 1,8-cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research .
Thorsten Seidel, Greiner, Johannes F-W, Marie-Theres Zeuner, Klenke, Christin, Grunwald, Lena-Marie, Stefan Hauser, Christian Kaltschmidt, Greiner, Johannes ; https://orcid.org/, Christin Klenke, Kaltschmidt, Christian, Johannes F.-W. Greiner, Kaltschmidt, Barbara, Sudhoff, Holger, Janine Müller, Sudhoff, Holger ; https://orcid.org/, Lena-Marie Grunwald, Müller, Janine, Darius Widera, Holger Sudhoff, Timo Schomann, Widera, Darius, Grunwald, Lena, Widera, Darius ; https://orcid.org/, Zeuner, Marie, Hauser, Stefan, Barbara Kaltschmidt, Zeuner, Marie-Theres, Seidel, Thorsten, Schomann, Timo   +28 more
core   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source