Results 221 to 229 of about 574,970 (229)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

IL-24 Induces Cell Dormancy and Oxaliplatin Resistance in Colon Cancer Cells by Activating NF-κB Pathway. [PDF]

Mol Carcinog
Hu Y, Li S, Zhu M, Gong C, Fang Z.
europepmc   +1 more source

Hirudin Attenuates Uric Acid-Induced Renal Tubular Injury via TNFRSF6B-Mediated Suppression of NF-κB Signaling. [PDF]

Pharmacol Res Perspect
Zhao Y, Qin Y, He L, Luo H, Mo Y, Zhou W, He H, Zhou G, Liu X.   +8 more
europepmc   +1 more source

Cardamonin ameliorates neuroinflammation in Parkinson's disease by regulating NF-κB signaling. [PDF]

Hereditas
Xia Y, Zhang Y, Li Y, Li X, Wu Y, Yao Q.
europepmc   +1 more source

Targeting MEST using cobicistat as a therapeutic strategy for gastric cancer through suppressing NF-κB signaling. [PDF]

Front Oncol
Cao H, Ye H, Zhang W, Cai W, Han H, Zhu J, Dong Y, Shi W, Zhang Z, Qin L, Jiao Z.   +10 more
europepmc   +1 more source

Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer. [PDF]

Oncol Rep
Han K, Zhang Q, Gao S, Zhang J, Mei X, Li F, Xu X, Li S, Chen G.   +8 more
europepmc   +1 more source

Correction to "Clusterin Silencing in Prostate Cancer Induces Matrix Metalloproteinases by an NF-κB-Dependent Mechanism". [PDF]

J Oncol
europepmc   +1 more source