Results 181 to 190 of about 783,867 (386)

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

Conformational changes induced by DNA binding of NF-κB [PDF]

, 1995
James R. Matthews, John Nicholson, Ellis Jaffray, Sharon M. Kelly, Nicholas C. Price, Ronald T. Hay   +5 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Shared Principles in NF-κB Signaling

Cell, 2008
M. Hayden, S. Ghosh
semanticscholar   +1 more source

Nuclear factor NF-κB in myocardium: developmental expression of subunits and activation by interleukin-1β in cardiac myocytes in vitro [PDF]

, 1998
David A.M. Norman, Magdi H. Yacoub, Paul J.R. Barton   +2 more
openalex   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

Inhibition of Ets-1 DNA Binding and Ternary Complex Formation between Ets-1, NF-κB, and DNA by a Designed DNA-binding Ligand [PDF]

, 1999
Liliane A. Dickinson, John W. Trauger, Eldon E. Baird, Peter B. Dervan, Barbara J. Graves, Joel Gottesfeld   +5 more
openalex   +1 more source

Mechanical Stretching Suppresses NF-κB Activity in Fibroblasts

, 2008
During orthodontie tooth movement, mechanical loads applied to the tooth induce remodeling of the periodontal ligament (PDL) and alveolar bone. On the tension side, fibroblasts of the PDL are subjected to stretch, but little is known about how stretch is transduced into biological responses.
openaire   +1 more source

Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice

, 1995
Transcription factors belonging to the NF-κB family are controlled by inhibitory IκB proteins, mainly IκBα and IκBβ. Apparently normal at birth, IκBα^(-/-) mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days.
Beg, Amer A., Sha, William C., Bronson, Roderick T., Baltimore, David   +3 more
openaire   +2 more sources

デキストラン リュウサン ユウハツ マウス ダイチョウエン ニ タイスル リポソーム フウニュウ NF-κB デコイ オリゴ デオキシリボ カクサン ノ ケントウ [PDF]

, 2009
BACKGROUNDS/AIMS: Double strand nuclear factor-κB decoy oligodeoxynucleotide (NF-κB-Decoy) had been investigated as a potential therapeutic approach in ulcerative colitis.
武田 弘明, 河田 純男, 鈴木 康之   +2 more
core   +1 more source