Results 231 to 240 of about 360,317 (299)

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Advanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou   +17 more
wiley   +1 more source

Acupuncture protects against ischemic stroke by inhibiting the NF-κB pathway. [PDF]

IBRO Neurosci Rep
Wang L, Chen L, Wu J, Liu C, Chi C, Wang S.   +5 more
europepmc   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Interaction between NF-κB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium. [PDF]

Sci Adv
Shukla V, Tyagi A, Chandrasekaran B, Tyagi B, Singh B, Devanarayanan TN, Kolluru V, K Ankem M, Damodaran C.   +8 more
europepmc   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Tripartite motif-containing 27 negatively regulates NF-κB activation in bone remodeling. [PDF]

Mol Med
Kim K, Kim JH, Kim I, Seong S, Kook H, Koh JT, Kim N.   +6 more
europepmc   +1 more source

Squaraine Dyes for Organic Photomultiplication Photodetectors with 220% External Quantum Efficiency at 1240 nm

Advanced Science, EarlyView.
The synthesis of a range of squaraine dyes is reported with maximum absorption in solution above 1100 nm. Near‐infrared sensitive organic photomultiplication photodetectors are developed. Photomultiplication occurs via squaraine hole trap‐induced injection of electrons from the external circuit.
Joshua Csucker, Elodie Didier, João Pedro Ferreira Assunção, Daniel Rentsch, Radha Kothandaraman, Dominik Bachmann, Ivan Shorubalko, Frank Nüesch, Roland Hany, Michael Bauer   +9 more
wiley   +1 more source

Isoliquiritigenin Alleviates Periodontitis by Suppressing Inflammation via NF-κB Signaling Pathway of Immune Cell. [PDF]

J Inflamm Res
Wang X, Zhao T, Liang B, Fang J, Dong Q, Chen Q.   +5 more
europepmc   +1 more source