Results 291 to 299 of about 360,317 (299)

Natural Products and their Role as Inhibitors of the Pro-Inflammatory Transcription Factor NF-κB

Phytochemistry Reviews, 2005
Nuclear factor kappa B (NF-κB) is a transcription factor involved at the downstream stage of many signalling cascades and plays a crucial role in acute and chronic inflammatory conditions, induced and adaptive immunity, apoptosis and induced cell proliferation. For the last decade it has attracted intense research interest throughout the world.
Bremner, Paul, Heinrich, Michael
openaire   +3 more sources

Store‐Operated Calcium Entry Upregulated IL6 Expression in Glomerular Mesangial Cells through NF‐κB Pathway

The FASEB Journal, 2020
BackgroundIL6 is a pleotropic cytokine and functions as a pro‐ as well as anti‐inflammatory mechanism depending on the cell type or the specific pathological environment. It is unclear if a particular signaling pathway confers IL6 with this property.
Chaudhari, Sarika, Shotorbani, Parisa Yazdizadeh, Wei, Celine, Davis, Mark E., Ma, Rong   +4 more
openaire   +3 more sources

Lipopolysaccharide pretreatment inhibits oxidative stress-induced endothelial progenitor cell apoptosis via a TLR4-mediated PI3K/Akt/ NF-κB p65 signaling pathway

Cellular and Molecular Biology, 2019
Endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Transplantation with EPCs is a therapeutic strategy for the treatment of ischemic diseases. However, the transplanted EPCs are susceptible to adverse environments such as hypoxia, inflammation and oxidative stress.
Meihui Wang, Guosheng Fu, Liang Xia
openaire   +3 more sources

Inhibition of DNA Binding by NF-κB with Pyrrole-Imidazole Polyamides

Biochemistry, 2002
Synthetic ligands that bind to predetermined DNA sequences will offer a chemical approach to gene regulation if inhibition of a broad range of transcription factors can be achieved. NF-kappa B is a transcription factor that regulates a multitude of genes, including those involved in immune, inflammatory, and anti-apoptotic responses.
Wurtz, Nicholas R., Pomerantz, Joel L., Baltimore, David, Dervan, Peter B.   +3 more
openaire   +4 more sources

The Role of NF-_B Signaling in Rotator Cuff Tendinopathy

2016
Tendon injuries are the cause of 1 in 16 physician visits, while rotator cuff tendon injury affects over 17 million Americans annually. Chronic tendon injuries are associated with repetitive mechanical strain and loading, often without macroscopic damage at the tendon level.
openaire   +3 more sources

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

Cell, 1991
Abstract The sequence and biochemical properties of the product of the cloned cDNA for the p65 subunit of nuclear factor κB (NF-κB) have been determined. The cDNA has an open reading frame of 549 amino acids capable of encoding a 60 kd protein. NF-κB p65 contains an amino-terminal region of 320 amino acids with extensive similarity to the oncogene c ...
Garry P. Nolan, Hsiou-Chi Liou, Paul Tempst, David Baltimore, David Baltimore, Sankar Ghosh   +5 more
openaire   +3 more sources

NF-κB p50: THE ROLE OF REDOX SIGNALING AND LOSS OF FUNCTION IN DYSREGULATED MICROGLIAL ACTIVATION

2014
VCU Theses and ...
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CD28-mediated activation of NF-κB in CD45RA+ and CD45RO+ T cells

Immunology Letters, 1997
openaire   +1 more source

Pre-exposure to oxidative stress decreases the NF-κB dependent transcription in T lymphocytes

Immunology Letters, 1997
openaire   +2 more sources