Results 91 to 100 of about 456,853 (317)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Hypoxia-induced NLRP3 inflammasome activation via the HIF-1α/NF-κB signaling pathway in human dental pulp fibroblasts

BMC Oral Health
Background Previous studies have reported the link between hypoxic conditions and NLRP3 inflammasome-mediated pulpal inflammation in the progression of pulpitis. However, the underlying mechanism has not been fully elucidated.
Diya Wang, Minghao Wang, Shukai Sun, Chongyang Zhang, Ya Song, Jianing Li, Bing Song, Haipeng Lv, Shengchao Wang, Wenkai Jiang   +9 more
doaj   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +3 more sources

Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia‐mediated ERK1/2–NF‐κB signaling pathway

The FASEB Journal, 2019
Blood‐retinal barrier (BRB) breakdown is a typical event in the early stage of diabetic retinopathy (DR). This study aims to elucidate the protection of erianin, a natural compound isolated from Dendrobium chrysotoxum Lindl, against DR development ...
Tian-yu Zhang, Ouyang Hao, Xiyu Mei, Bin Lu, Zengyang Yu, Kaixian Chen, Zhengtao Wang, Lili Ji   +7 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Frontiers in Pharmacology
Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB signaling pathway regulates a wide range of physiological processes, such as cell survival, growth, and
Pratibha Pandey, Sorabh Lakhanpal, Danish Mahmood, Han Na Kang, Byunggyu Kim, Sojin Kang, Jinwon Choi, Min Choi, Shivam Pandey, Mahakshit Bhat, Shilpa Sharma, Fahad Khan, Moon Nyeo Park, Bonglee Kim, Bonglee Kim   +14 more
doaj   +1 more source

CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]

, 2018
The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad, Gilmore, Thomas, Kagermazova, Larisa, Liu, Yuekun, Mccaslin, Ethan, Miyamoto, Shigeki, Wuerzberger-Davis, Shelly, Yeo, Alan   +7 more
core   +1 more source

Targeting NF-κB signaling pathway in cancer by dietary polyphenols

Critical reviews in food science and nutrition, 2019
Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the
H. Khan, Hammad Ullah, P. Castilho, A. Gomila, G. D’Onofrio, R. Filosa, F. Wang, S. Nabavi, M. Daglia, A. S. Silva, Kannan R. R. Rengasamy, J. Ou, Xiaobo Zou, Jianbo Xiao, H. Cao   +14 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response. [PDF]

, 2017
Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection.
Chen, Huizi, Chen, Jun, Chen, Zhinan, Li, Fanni, LIU, Fenyong, Xia, Sisi, Yang, Xiangmin   +6 more
core   +2 more sources