Results 141 to 150 of about 456,853 (317)

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Novel components in the nuclear factor-kappa B (NF-κB) signaling pathways of endothelial cells under hyperglycemic-ischemic conditions

Frontiers in Cardiovascular Medicine
Diabetes worsens the outcomes of a number of vascular disorders including peripheral arterial disease (PAD) at least in part through induction of chronic inflammation.
Madhu V. Singh, Thomas Wong, Sonia Moorjani, Arul M. Mani, Ayotunde O. Dokun   +4 more
doaj   +1 more source

EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats

Canadian Journal of Gastroenterology and Hepatology, 2017
Objective To observe the protective effect of epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway.
X. Bing, Liu Xue-lei, Dong Wanwei, Liang Linlang, Chen Keyan   +4 more
semanticscholar   +1 more source

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells

Advanced Healthcare Materials, EarlyView.
Membrane vesicles derived from the probiotic Lacticaseibacillus casei BL23 demonstrate antimicrobial properties against Escherichia coli and a potential biological effect in improving the overall survival of C. elegans infected with Pseudomonas aeruginosa. These vesicles stimulated immune responses in primary cells without causing toxicity. Our results
Cecilia L. D'Antoni, Leila Pourtalebi Jahromi, Lorenzo Sana, Ana Paula Domínguez Rubio, Maja Dorfner, Jennifer Munkert, Heike Danzer, Philipp Arnold, Mikhail Lebedev, Esther Zanin, Oscar E. Pérez, Gregor Fuhrmann   +11 more
wiley   +1 more source

Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway

International Journal of Molecular Sciences, 2019
Hyperoside (quercetin 3-o-β-d-galactopyranoside) is one of the flavonoid glycosides with anti-inflammatory, antidepressant, and anti-cancer effects. But it remains unknown whether it had effects on breast cancer.
Jinxia Qiu, Tao Zhang, Xinying Zhu, Chao Yang, Yaxing Wang, N. Zhou, Bingxin Ju, T. Zhou, Ganzhen Deng, Changwei Qiu   +9 more
semanticscholar   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Aged garlic attenuates neuroinflammation via modulating the NF-κB pathway: Insights from multi-omics analyses

Food & Nutrition Research
Background: Neuroinflammation is a key pathological feature in many neurodegenerative diseases, and the nuclear factor kappa-B (NF-κB) signaling pathway is a central mediator of this response.
Junjun Meng, Chengquan Wen, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Wenxiu Han, Pei Jiang   +7 more
doaj   +1 more source

Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats

Mediators of Inflammation, 2011
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (
Zhong Wang, Gang Zuo, Xiao-Yong Shi, Jian Zhang, Qi Fang, Gang Chen   +5 more
doaj   +1 more source

Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway

Molecular Cancer, 2017
Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers.
Li Wang, Wei Zhou, Y. Zhong, Yongbao Huo, P. Fan, Sudong Zhan, Jun Xiao, Xin Jin, S. Gou, T. Yin, Heshui Wu, Tao Liu   +11 more
semanticscholar   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source