Results 101 to 110 of about 270,662 (312)

Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways

Molecules, 2018
Inflammatory bowel disease (IBD) is a notable health problem and may considerably affect the quality of human life. Previously, the protective roles of tryptanthrin (TRYP) against dextran sulfate sodium (DSS) induced colitis has been proved, but the ...
Zheng Wang, Xue Wu, Cui-Ling Wang, Li Wang, Chen Sun, Dong-Bo Zhang, Jian-Li Liu, Yan-Ni Liang, Dong-Xin Tang, Zhi-Shu Tang   +9 more
doaj   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy

Journal of Inflammation Research, 2015
Kevin J Ruff,1 Paul L Durham,2 Austin O’Reilly,2 F Daniel Long1 1ESM Technologies, LLC, Carthage, MO, USA; 2Center for Biomedical and Life Sciences, Missouri State University, Springfield, MO, USA Purpose: Eggshell membrane (ESM) has been shown to
Ruff KJ, Durham PL, O’Reilly A, Long FD   +3 more
doaj  

Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

eLife
The inhibitor of kappa-B kinase (IKK) complex is a critical regulator of cell death and inflammatory signalling in multiple cell types. Phosphorylation of IκB proteins by IKK results in their degradation and consequent activation of NF-κB transcription ...
Farjana Islam, Cayman Williams, Thea Hogan, Louise V Webb, Ines Boal-Carvalho, Benedict Seddon   +5 more
doaj   +1 more source

Nanotherapy targeting NF-κB attenuates acute pain after joint injury

Precision Nanomedicine, 2019
Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and ...
Huimin Yan, Xin Duan, Kelsey H. Collins, Luke E. Springer, Farshid Guilak, Samuel A. Wickline, M. Farooq Rai, Hua Pan, Christine Pham   +8 more
doaj   +1 more source

Promotion of Hendra virus replication by microRNA 146a

, 2013
Hendra virus is a highly pathogenic zoonotic paramyxovirus in the genus Henipavirus. Thirty-nine outbreaks of Hendra virus have been reported since its initial identification in Queensland, Australia, resulting in seven human infections and four ...
A. G. Bean, A. J. Foord, Algarte, Bartel, Boldin, Brown, C. Deffrasnes, C. R. Stewart, Cahir McFarland, Cameron, Chen, Ciancanelli, D. Middleton, DiDonato, Feldman, Fiedler, G. A. Marsh, Gantier, Gantier, Gilad, Griffin, H. G. Heine, Halpin, Hou, J. A. Pallister, J. Haining, J. Stambas, J. W. Lowenthal, Jacque, Jopling, K. A. Jenkins, L. Izzard, L.-F. Wang, Lanford, Laurie, Lee, Lee, Levy, Li, Liu, M. L. Tizard, M. P. Gantier, Marianneau, Marsh, Marusawa, Meister, Mitchell, Murray, O'Connell, Pahl, Pallister, Pegtel, Pierce, Playford, R. Robinson, Reed, Santhakumar, Sarasin-Filipowicz, Schwarz, Shaw, Shembade, Shi, T. J. Gough, Taganov, Tomari, Virtue, Wang, Yoneyama, Zhao   +68 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

TNF-induced activation of NF-kappa B.

Immunobiology, 1996
Tumor Necrosis Factor (TNF) is one of the most potent physiological inducers of the nuclear transcription factor NF-kappa B. In light of the pivotal role of NF-kappa B in the development of immune responses and activation of HIV replication, the identification of TNF signal transduction pathways involved in NF-kappa B activation is of particular ...
S, Schütze, K, Wiegmann, T, Machleidt, M, Krönke   +3 more
openaire   +2 more sources

Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner. [PDF]

, 2015
Objective:Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene.
Afaq, Ahmed, An, An, An, An, An, Baba, Bosniak, DeSantis, Figlin, Hollingsworth, Koyama, Lamb, Mori, Oya, Oya, Rasheed, Rendon, Rettig, Schubert, Seeram, Semenza, Siegel, Smith, Thomas, Volpe, Wehle, Yang   +28 more
core   +2 more sources

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source