Results 81 to 90 of about 12,632,659 (295)

Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

eLife
The inhibitor of kappa-B kinase (IKK) complex is a critical regulator of cell death and inflammatory signalling in multiple cell types. Phosphorylation of IκB proteins by IKK results in their degradation and consequent activation of NF-κB transcription ...
Farjana Islam, Cayman Williams, Thea Hogan, Louise V Webb, Ines Boal-Carvalho, Benedict Seddon   +5 more
doaj   +1 more source

Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice

Molecules, 2018
Fargesin is a bioactive lignan from Flos Magnoliae, an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia. We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice ...
Bei Yue, Yi-Jing Ren, Jing-Jing Zhang, Xiao-Ping Luo, Zhi-Lun Yu, Gai-Yan Ren, A-Ning Sun, Chao Deng, Zheng-Tao Wang, Wei Dou   +9 more
doaj   +1 more source

Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.

, 2004
International audienceNF-kappa B essential modulator/IKK-gamma (NEMO/IKK-gamma) plays a key role in the activation of the NF-kappa B pathway in response to proinflammatory stimuli.
Chiaravalli, Jeanne, Baleux, Françoise, Agou, Fabrice, Israël, Alain, Coïc, Yves-Marie, Courtois, Gilles, Véron, Michel, Traincard, François   +7 more
core   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

The IKK2/NF-kappa B pathway suppresses MYC-induced lymphomagenesis

, 2009
Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematologic malignancies, enhanced NF-kappa B exerts prosurvival functions.
Dragan Marinkovic, Wirth, Thomas, Bernd Baumann, Baumann, Bernd, Sandrine Sander, Sander, Sandrine, Marinković, Dragan, Kay Klapproth, Thomas Wirth, Klapproth, Kay   +9 more
core   +1 more source

Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways

Molecules, 2018
Inflammatory bowel disease (IBD) is a notable health problem and may considerably affect the quality of human life. Previously, the protective roles of tryptanthrin (TRYP) against dextran sulfate sodium (DSS) induced colitis has been proved, but the ...
Zheng Wang, Xue Wu, Cui-Ling Wang, Li Wang, Chen Sun, Dong-Bo Zhang, Jian-Li Liu, Yan-Ni Liang, Dong-Xin Tang, Zhi-Shu Tang   +9 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Neuroprotection by triptolide against cerebral ischemia/reperfusion injury through the inhibition of NF-ΚB/PUMA signal in rats

Therapeutics and Clinical Risk Management, 2016
Bin Zhang,1 Cunfeng Song,1 Bo Feng,1 Weibing Fan2 1Department of Neurology, The Third Hospital of Liaocheng, Liaocheng, Shandong, 2Department of Neurology, The Third Hospital of Changsha, Changsha, Hunan, People’s Republic of China Abstract ...
Zhang B, Song C, Feng B, Fan W
doaj  

Nanotherapy targeting NF-κB attenuates acute pain after joint injury

Precision Nanomedicine, 2019
Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and ...
Huimin Yan, Xin Duan, Kelsey H. Collins, Luke E. Springer, Farshid Guilak, Samuel A. Wickline, M. Farooq Rai, Hua Pan, Christine Pham   +8 more
doaj   +1 more source

Herpes simplex virus disrupts NF-kappa B regulation by blocking its recruitment on the I kappa B alpha promoter and directing the factor on viral genes.

, 2006
Herpes simplex viruses (HSVs) are able to hijack the host-cell I kappa B kinase (IKK)/NF-kappa B pathway, which regulates critical cell functions from apoptosis to inflammatory responses; however, the molecular mechanisms involved and the outcome of the ...
C. Amici, Antonio Rossi, Ciafre, S, Marinari, B, SANTORO, MARIA GABRIELLA, LEVRERO, Massimo, Carla Amici, Costanzo, A, S. Ciafrè, M. Gabriella Santoro, Barbara Marinari, Antonio Costanzo, Balsamo, M, COSTANZO, ANTONIO, A. Costanzo, AMICI, CARLA, A. Rossi, Mirna Balsamo, Amici, C, M. Balsamo, Santoro, MG, M. G. Santoro, Rossi, A, B. Marinari, Massimo Levrero, Levrero, M, Stefania Ciafrè   +26 more
core   +1 more source