Results 91 to 100 of about 270,662 (312)

NFKB1 and Cancer: Friend or Foe?

Cells, 2018
Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway is associated with carcinogenesis. A number of key cellular processes are governed by the effectors of this pathway, including immune responses and ...
Julia Concetti, Caroline L. Wilson
doaj   +1 more source

NF-κB-dependent synergistic regulation of CXCL10 gene expression by IL-1β and IFN-γ in human intestinal epithelial cell lines [PDF]

, 2008
Background and aims Little is known about the intestinal epithelial expression and secretion of CXCL10 (IP-10), a chemokine involved in recruiting T cells and monocytes.
Sunil Yeruva, Giuliano Ramadori, Dirk Raddatz, M Baggiolini, M Baggiolini, DD Taub, DD Taub, DH Adams, F Sierro, S Brand, N Marx, DM Boorsma, T Dajotoy, S Gasperini, MB Dwinell, AD Luster, JM Farber, C Banks, M Uguccioni, S Sasaki, X Yang, I Narvaiza, SK Yang, HC Jung, MH Wong, FG Que, U Bocker, D Raddatz, S Majumder, AC Warhurst, G Rogler, M Saura, R Ito, JG Hyun, A Zipin-Roitman, N Kanda, EL Hardaker, Y Ohmori, A Lee, R Pine, W Czech, Y Takami, D Elewaut, JM Kim, JA Kim, S Vallee, TE Pietila, M Hiroi, K Schlottmann   +48 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells [PDF]

, 2015
NF-kappa B is a well-characterized transcription factor, widely known as a key player in tumor-derived inflammation and cancer development. Herein, we present the functional and molecular relevance of the canonical NF-kappa B p65 subunit in ...
Cheung, AKL, Dai, W, KAN, PQR, Kwong, DLW, Lee, AWM, Lung, HL, Lung, ML, Ng, WT, Ngan, RK, Shuen, WH, Tung, S, Yau, CC   +11 more
core   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Id-1 Promotes Reendothelialization In The Early Phase After Vascular Injury Through Activation Of NFkB/survivin Signaling Pathway

Drug Design, Development and Therapy, 2019
Wei Li, Dayong Du, Yuntian Li Department of Cardiology, Beijing 100017, People’s Republic of ChinaCorrespondence: Yuntian LiDepartment of Cardiology, 305 Hospital of PLA, Beijing 100017, People’s Republic of ChinaTel +86-13811021786Email ...
Li W, Du D, Li Y
doaj  

Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice

Molecules, 2018
Fargesin is a bioactive lignan from Flos Magnoliae, an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia. We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice ...
Bei Yue, Yi-Jing Ren, Jing-Jing Zhang, Xiao-Ping Luo, Zhi-Lun Yu, Gai-Yan Ren, A-Ning Sun, Chao Deng, Zheng-Tao Wang, Wei Dou   +9 more
doaj   +1 more source

Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappa B, and proinflammatory cytokines [PDF]

, 2005
Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives.
Spann, Kirsten M., Tran, Kim C., Collins, Peter L.   +2 more
core   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Neuroprotection by triptolide against cerebral ischemia/reperfusion injury through the inhibition of NF-ΚB/PUMA signal in rats

Therapeutics and Clinical Risk Management, 2016
Bin Zhang,1 Cunfeng Song,1 Bo Feng,1 Weibing Fan2 1Department of Neurology, The Third Hospital of Liaocheng, Liaocheng, Shandong, 2Department of Neurology, The Third Hospital of Changsha, Changsha, Hunan, People’s Republic of China Abstract ...
Zhang B, Song C, Feng B, Fan W
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