Results 181 to 190 of about 99,051 (206)
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NF-kappaB activation in melanoma.
Pigment cell research, 2006Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor-kappa B (NF-kappaB) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF-kappaB, (ii ...
Yukiko, Ueda, Ann, Richmond
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NF-kappaB functions in osteoclasts.
Biochemical and biophysical research communications, 2008NF-kappaB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappaB p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappaB is essential for RANK-expressing osteoclast precursors to ...
N S, Soysa, N, Alles
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Assessing acetylation of NF-kappaB.
Methods (San Diego, Calif.), 2005To achieve its full biological activity, NF-kappaB must undergo a variety of post-translational modifications, including acetylation. Acetylation plays a prominent role in regulating the nuclear action of NF-kappaB. The RelA subunit of NF-kappaB forms the major target of acetylation at several different sites. Acetylation of discrete lysine residues in
Lin-Feng, Chen, Warner C, Greene
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NF-kappaB activation in sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2001Sarcoidosis is an inflammatory disorder of unknown origin. The nuclear regulatory factor-kappaB (NF-kappaB) appears to play a key role in immune and inflammatory processes such as asthma, rheumatoid arthritis and inflammatory bowel disease. We hypothesized that NF-kappaB activation might be involved in the pathological process of sarcoidosis.Twelve ...
Drent, M. +5 more
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NF-kappaB in pancreatic cancer.
International journal of gastrointestinal cancer, 2004Although the genetic profile of pancreatic cancer is emerging as a result of much research, the role of specific genetic alterations that initiate tumorigenesis and produce its cardinal clinical features of locally aggressive growth, metastasis, and chemotherapy resistance remains unresolved. Recently, a number of studies have shown that the inhibition
Guido M, Sclabas +4 more
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Molecular cell, 2002
NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune ...
Joel L, Pomerantz, David, Baltimore
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NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune ...
Joel L, Pomerantz, David, Baltimore
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NF-kappaB-related genetic diseases.
Cell death and differentiation, 2006The recent identification of genetic diseases (incontinentia pigmenti, anhidrotic ectodermal dysplasia with immunodeficiency and cylindromatosis) resulting from mutations affecting components of the nuclear factor-kappaB (NF-kappaB) signaling pathway provides a unique opportunity to understand the function of NF-kappaB in vivo.
G, Courtois, A, Smahi
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Cellular and molecular life sciences : CMLS, 2007
Members of the NF-kappaB family of transcription factors play critical roles in regulating immunity and cell survival and contribute to cancer progression and chemoresistance. Over the past 20 years, much has been learned about the remarkable complexity in regulation of NF-kappaB signaling.
A M, Mabb, S, Miyamoto
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Members of the NF-kappaB family of transcription factors play critical roles in regulating immunity and cell survival and contribute to cancer progression and chemoresistance. Over the past 20 years, much has been learned about the remarkable complexity in regulation of NF-kappaB signaling.
A M, Mabb, S, Miyamoto
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Methylglyoxal suppresses TNF-alpha-induced NF-kappaB activation by inhibiting NF-kappaB DNA-binding.
Biochemical pharmacology, 2007Methylglyoxal is a cytotoxic metabolite that is produced in vivo mainly from glycolysis. Increased production of methylglyoxal can be induced by tumor necrosis factor and occurs in a number of pathological conditions, including diabetes and neurodegenerative disorders.
Mathias, Laga +7 more
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NF-kappaB signaling: pros and cons of altering NF-kappaB as a therapeutic approach.
Annals of the New York Academy of Sciences, 2006The transcription factor, nuclear factor-kappaB (NF-kappaB), is a dominant regulator of the expression of hundreds of genes, many of which play important roles in the regulation of inflammation and programmed cell death (apoptosis). Since the discovery of NF-kappaB in the mid 1980s, this transcription factor has been the subject of intense ...
Laurence J, Egan, Murat, Toruner
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