Results 231 to 240 of about 41,205 (276)
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Inhibitors of the Calcineurin / NFAT Pathway
Current Medicinal Chemistry, 2004The well known calcium-sensitive phosphatase calcineurin is implicated in many eukaryotic activation and developmental programmes, including lymphocyte activation, heart-valve morphogenesis, angiogenesis, and neural and muscle development. The importance of this phosphatase is graphically illustrated by the observation that the immunosuppressive ...
Sara, Martínez-Martínez +1 more
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NFAT expression in human osteoclasts
Journal of Cellular Biochemistry, 2005AbstractNuclear factor of activated T‐cells cytoplasmic (NFATc) is a family of transcription factors originally identified in T‐cells. The gene family is currently known to have four members (NFATc1 through NFATc4) which have roles both within and outside the immune system.
Day, CJ +4 more
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NFAT signaling and the invention of vertebrates
Trends in Cell Biology, 2007The calcium/calcineurin-dependent NFATc family is thought to have arisen following the recombination of an ancient precursor with a Rel domain about 500 million years ago, producing a new group of signaling and transcription factors (the NFATc genes) found only in the genomes of vertebrates.
Hai, Wu +3 more
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Science's STKE, 2006
Obesity is a common health problem in the United States and other countries, so intensive efforts are focused on understanding the signaling pathways that control metabolism and the growth and physiology of fat-storing cells (adipocytes). Noting that there are similarities in obesity and inflammatory responses, Yang et al
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Obesity is a common health problem in the United States and other countries, so intensive efforts are focused on understanding the signaling pathways that control metabolism and the growth and physiology of fat-storing cells (adipocytes). Noting that there are similarities in obesity and inflammatory responses, Yang et al
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Clinical and Experimental Pharmacology and Physiology, 2019
This study investigated the role of NFAT/Fas/FasL axis in cardiomyocyte apoptosis following doxorubicin (DOX) treatment in rats and evaluated the involvement and regulation of all NFAT members in cardiac apoptosis.
A. Shati
semanticscholar +1 more source
This study investigated the role of NFAT/Fas/FasL axis in cardiomyocyte apoptosis following doxorubicin (DOX) treatment in rats and evaluated the involvement and regulation of all NFAT members in cardiac apoptosis.
A. Shati
semanticscholar +1 more source
The Role of NFAT in Osteoclast Formation
Annals of the New York Academy of Sciences, 2007Abstract: Osteoclasts are cells of monocyte–macrophage origin that degrade bone matrix. Receptor activator of NF‐κB ligand (RANKL) induces osteoclast formation in the presence of macrophage‐colony‐stimulating factor (M‐CSF) and costimulatory signals.
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Science Signaling, 2002
Signals from the T cell receptor cause T cell activation if signaling also occurs through costimulatory receptors. But activation of the T cell receptor alone causes the cells to become unresponsive or anergic, producing immune tolerance. Macián et al.
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Signals from the T cell receptor cause T cell activation if signaling also occurs through costimulatory receptors. But activation of the T cell receptor alone causes the cells to become unresponsive or anergic, producing immune tolerance. Macián et al.
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Journal of Immunology, 2019
Key Points T cell signals trigger activation of multiple events in the teleost Ca2+–NFAT axis. Tight regulation of Ca2+–NFAT is pivotal for teleost T cell activation and function.
Xiu-Mei Wei +6 more
semanticscholar +1 more source
Key Points T cell signals trigger activation of multiple events in the teleost Ca2+–NFAT axis. Tight regulation of Ca2+–NFAT is pivotal for teleost T cell activation and function.
Xiu-Mei Wei +6 more
semanticscholar +1 more source
Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma.
Blood, 2019Diffuse large B-cell lymphoma (DLBCL) represents the most common adult lymphoma that is divided into two major molecular subtypes, the germinal center B-cell-like (GCB) and the aggressive activated B-cell-like (ABC) DLBCL. Previous studies suggested that
Philip Bucher +15 more
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Nature Immunology, 2006
The transcription factor Foxp3 is essential for regulatory T cell function, yet how Foxp3 operates has remained elusive until now.
Lena Ho, Gerald Crabtree
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The transcription factor Foxp3 is essential for regulatory T cell function, yet how Foxp3 operates has remained elusive until now.
Lena Ho, Gerald Crabtree
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