Results 211 to 220 of about 32,558 (245)
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Nature Immunology, 2006
The transcription factor Foxp3 is essential for regulatory T cell function, yet how Foxp3 operates has remained elusive until now.
Lena Ho, Gerald Crabtree
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The transcription factor Foxp3 is essential for regulatory T cell function, yet how Foxp3 operates has remained elusive until now.
Lena Ho, Gerald Crabtree
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Structure of NFAT Bound to DNA as a Monomer
Journal of Molecular Biology, 2003The nuclear factor of activated T cells (NFAT) is a calcium-dependent transcription factor that cooperates with a myriad of partner transcription factors to regulate distinct transcription programs. Transcription activation by NFAT without the cooperation of co-stimulatory signals in lymphocytes can also impose a genetic program of anergy. Although the
James C, Stroud, Lin, Chen
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Science Signaling, 2002
Signals from the T cell receptor cause T cell activation if signaling also occurs through costimulatory receptors. But activation of the T cell receptor alone causes the cells to become unresponsive or anergic, producing immune tolerance. Macián et al.
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Signals from the T cell receptor cause T cell activation if signaling also occurs through costimulatory receptors. But activation of the T cell receptor alone causes the cells to become unresponsive or anergic, producing immune tolerance. Macián et al.
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NFAT in Lymphocytes: A Factor for All Events?
Science's STKE, 2007A typical immune response to infection by a microbe results in rapid amplification and subsequent differentiation of a few antigen-specific naïve lymphocytes into many effector lymphocytes. Upon antigen exposure, these effector T or B cells rapidly secrete large amounts of either lymphokines (cytokines produced by lymphocytes) or soluble antibodies ...
Edgar, Serfling +2 more
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Science's STKE, 2002
Carcinoma cells can invade surrounding normal tissue, and integrins have been linked to promoting such progression because of their role in regulating cell adhesion and migration. Jauliac et al. report a correlation in breast and colon cancer cells between the expression of integrins containing the β 4
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Carcinoma cells can invade surrounding normal tissue, and integrins have been linked to promoting such progression because of their role in regulating cell adhesion and migration. Jauliac et al. report a correlation in breast and colon cancer cells between the expression of integrins containing the β 4
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Science's STKE, 2006
Two independent groups obtained evidence linking dysregulation of nuclear factor of activated T cells (NFAT) signaling with Down syndrome. Down syndrome, most commonly associated with an extra copy of chromosome 21, is characterized by a constellation of traits that include mild to moderate mental retardation; neurological, skeletal ...
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Two independent groups obtained evidence linking dysregulation of nuclear factor of activated T cells (NFAT) signaling with Down syndrome. Down syndrome, most commonly associated with an extra copy of chromosome 21, is characterized by a constellation of traits that include mild to moderate mental retardation; neurological, skeletal ...
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NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells
Biomedicine and Pharmacotherapy, 2023Yifu Song, Ana Hou, Sheng Han
exaly