Results 201 to 210 of about 32,558 (245)
Science Signaling, 2011 Loss of the kinase LRRK2 promotes the activity of the transcription factor NFAT, leading to enhanced inflammatory bowel disease.
John F. Foley
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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Annual Review of Immunology, 1997 ▪ Abstract As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of activated T cells) family have been the focus of much attention. NFAT proteins, which are expressed in most immune-system cells, play a pivotal role in the transcription of cytokine genes and other genes critical for the ...
A, Rao, C, Luo, P G, Hogan
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Calcineurin/NFAT signalling inhibits myeloid haematopoiesis
EMBO Molecular Medicine, 2012 Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signalling can also mediate granulocyte and dendritic cell (DC) activation, but it is unknown
Jan Fric +2 more
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Alternative splicing and expression of human and mouse NFAT genes
Genomics, 2008 Four members of the nuclear factor of activated T cells (NFAT) family (NFATC1, NFATC2, NFATC3, and NFATC4) are Ca2+-regulated transcription factors that regulate several processes in vertebrates, including the development and function of the immune ...
Hanna Vihma +2 more
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Inhibitors of the Calcineurin / NFAT Pathway
Current Medicinal Chemistry, 2004The well known calcium-sensitive phosphatase calcineurin is implicated in many eukaryotic activation and developmental programmes, including lymphocyte activation, heart-valve morphogenesis, angiogenesis, and neural and muscle development. The importance of this phosphatase is graphically illustrated by the observation that the immunosuppressive ...
Sara, Martínez-Martínez +1 more
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NFAT signaling and the invention of vertebrates
Trends in Cell Biology, 2007The calcium/calcineurin-dependent NFATc family is thought to have arisen following the recombination of an ancient precursor with a Rel domain about 500 million years ago, producing a new group of signaling and transcription factors (the NFATc genes) found only in the genomes of vertebrates.
Hai, Wu +3 more
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NFAT signaling in vertebrate development
Current Opinion in Genetics & Development, 2001NFATc proteins transduce Ca(2+) signals to the nucleus and then pair with other proteins on DNA to generate NFAT complexes that activate transcription in response to both electrical and tyrosine kinase signaling. The four NFATc genes arose at the origin of vertebrates, implying that they have evolved for the development of vertebrate-specific functions,
I A, Graef, F, Chen, G R, Crabtree
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NFAT expression in human osteoclasts
Journal of Cellular Biochemistry, 2005AbstractNuclear factor of activated T‐cells cytoplasmic (NFATc) is a family of transcription factors originally identified in T‐cells. The gene family is currently known to have four members (NFATc1 through NFATc4) which have roles both within and outside the immune system.
Day, CJ +4 more
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Science's STKE, 2006
Obesity is a common health problem in the United States and other countries, so intensive efforts are focused on understanding the signaling pathways that control metabolism and the growth and physiology of fat-storing cells (adipocytes). Noting that there are similarities in obesity and inflammatory responses, Yang et al
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Obesity is a common health problem in the United States and other countries, so intensive efforts are focused on understanding the signaling pathways that control metabolism and the growth and physiology of fat-storing cells (adipocytes). Noting that there are similarities in obesity and inflammatory responses, Yang et al
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The Role of NFAT in Osteoclast Formation
Annals of the New York Academy of Sciences, 2007Abstract: Osteoclasts are cells of monocyte–macrophage origin that degrade bone matrix. Receptor activator of NF‐κB ligand (RANKL) induces osteoclast formation in the presence of macrophage‐colony‐stimulating factor (M‐CSF) and costimulatory signals.
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