Transcription Factor Binding Site Enrichment Analysis In Co-Expression Modules In Celiac Disease [PDF]
, 2018 The aim of this study was to construct celiac co-expression patterns at a whole genome level and to identify transcription factors (TFs) that could drive the gliadin-related changes in coordination of gene expression observed in celiac disease (CD ...
Bilbao Catalá, José Ramón +11 more
core +3 more sources
Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells
Advanced Science, EarlyView.Nanoparticles are used to improve immunomodulatory therapies, but the impact of drug‐free nanomaterials on the immune system remains unknown. Screening common biomedical nanoparticles (NPs) reveals that PLGA NPs enhanced NK cell anti‐tumoral activity and transcriptional activation in human NK and pan T cells.
Vincent Mittelheisser +20 more
wiley +1 more source
Food Frontiers, EarlyView.In this study, we isolated and investigated the protective effect of 1,7‐diphenyl‐(6E)‐6‐hepten‐3‐ol (DPHP) against ulcerative colitis. Our results demonstrate that DPHP administration effectively alleviates colitis symptoms, inhibits inflammation, and strengthens antioxidant defense mechanisms. A combination of network pharmacology analysis, molecular
Van‐Long Truong +2 more
wiley +1 more source
Algebraic and Topological Indices of Molecular Pathway Networks in Human Cancers [PDF]
, 2014 Protein-protein interaction networks associated with diseases have gained prominence as an area of research. We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia
Hinow, Peter +2 more
core
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens [PDF]
, 2018 Genetic screens help infer gene function in mammalian cells, but it has remained difficult to assay complex phenotypes—such as transcriptional profiles—at scale.
Adamson, Britt +15 more
core +1 more source
Landscape of stimulation-responsive chromatin across diverse human immune cells. [PDF]
, 2019 A hallmark of the immune system is the interplay among specialized cell types transitioning between resting and stimulated states. The gene regulatory landscape of this dynamic system has not been fully characterized in human cells.
Anderson, Mark S +19 more
core
Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. [PDF]
, 2011 Gene regulatory networks inferred from RNA abundance data have generated significant interest, but despite this, gene network approaches are used infrequently and often require input from bioinformaticians.
Affara, Muna +18 more
core +2 more sources
Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development. [PDF]
PLoS ONE, 2018 Systemic autoimmune rheumatic disorders (SARD) represent important causes of morbidity and mortality in humans. The mechanisms triggering autoimmune responses are complex and involve a network of genetic factors.
Hammoudi Alkaissi +4 more
doaj +1 more source
Interactions between meat intake and genetic variation in relation to colorectal cancer [PDF]
, 2014 Supplementary material 1 (DOCX 46 ...
Andersen, Vibeke, Vogel, Ulla
core +2 more sources
Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease
Aging Cell, EarlyView.Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease‐Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single‐nucleus RNA‐seq from human brain tissues identified cholesterol‐related senescence gene co‐expression modules linked to microglial senescence.
Boyang Li +8 more
wiley +1 more source