Journal of Translational Medicine, 2022 Background Glioma is the most common cancer in the central nervous system, and low grade gliomas are notorious for many types of tumors and heterogeneity.
Yujie Zhou +2 more
semanticscholar +1 more source
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis [PDF]
, 2018 Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2.
A Kamburov +154 more
core +8 more sources
Frontiers in Neurology, 2022 Objective The purpose of this study was to identify potential therapeutic targets by examining the hub genes contributing to progression of intracranial aneurysm (IA) in patients with hypertension.
Yang Li, Zhen Zhang, Donghua Liu
semanticscholar +1 more source
NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages Through TPL-2-dependent ERK Activation [PDF]
, 2010 available in PMC 2012 February 15.Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear.
Agnes Mambole +14 more
core +1 more source
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis [PDF]
Human Molecular Genetics, 2003 Nuclear Factor-kappaB (NF-kappaB) is a major transcription regulator of immune response, apoptosis and cell-growth control genes, and is upregulated in inflammatory bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease. The NFKB1 gene encodes the NF-kappaB p105/p50 isoforms.
Amir Karban +16 more
openalex +4 more sources
NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome [PDF]
Bioscience Reports, 2019 Abstract The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved. NF-κB, a central regulator of inflammation, is involved in various inflammatory diseases. The aim of the present study was to explore the association between NFKB1 gene rs28362491 (-94ATTGins/del) polymorphism and ACS.
Siyu Jin +6 more
openalex +4 more sources
NFKB1 -94ins/delATTG polymorphism is a novel prognostic marker in first line-treated multiple myeloma [PDF]
, 2015 Nuclear factor kappa B (NFKB) plays an important role in multiple myeloma (MM), and bortezomib affects this pathway. We retrospectively analysed the effect of the NFKB1 -94ins/delATTG polymorphism on the survival of 295 MM patients treated at a single ...
Adam E +8 more
core +1 more source
The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer [PDF]
BMC Gastroenterology, 2015 We have demonstrated previously that NFKB1 single nucleotide polymorphism (SNP) rs4648068 GG homozygote was associated with the increased risk of gastric cancer in Chinese Han population. In this study, we constructed the recombinant plasmid pGL3-AA, pGL3-GG, pGL3-AA-NFKB and pGL3-GG-NFKB to investigate the function of rs4648068 by cell biology ...
Hui Zheng +7 more
openaire +3 more sources
Folia NeuropathologicaINTRODUCTION LncRNA LBX2-AS1 drives the development of various cancers, but the exact mechanism whereby LBX2-AS1 affects glioblastoma (GBM) progression is unaddressed.
Qiang Li, Yong Cheng
semanticscholar +1 more source
Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer [PDF]
, 2015 Colorectal cancer (CRC) is a heterogeneous disease that is associated with a gradual accumulation of genetic and epigenetic alterations. Among all CRC stages, stage II tumors are highly heterogeneous with a high relapse rate in about 20-25 % of stage II ...
Bi, Y +11 more
core +1 more source