Results 111 to 120 of about 20,241 (230)

The immune response mediator genes polymorphic variants as predictors of the etanercept efficacy in juvenile idiopathic arthritis

Russian Open Medical Journal, 2018
Objective ― The aim of the study was to investigate the relationship of the alleles and genotypes of the immune response mediator genes polymorphic loci (rs1800629, rs909253, rs16944, rs6822844, rs2104286, rs1800795, rs1800872, rs3087243, rs755622 ...
Liliia Sh. Nazarova, Ksenia V. Danilko, Viktor A. Malievsky, Akhat B. Bakirov, Tatiana V. Viktorova   +4 more
doaj   +1 more source

Genome-wide association study of treatment refractory schizophrenia in Han Chinese. [PDF]

PLoS ONE, 2012
We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified.
Ying-Jay Liou, Hui-Hung Wang, Ming-Ta Michael Lee, Sheng-Chang Wang, Hung-Lun Chiang, Cheng-Chung Chen, Ching-Hua Lin, Ming-Shun Chung, Chien-Cheng Kuo, Ding-Lieh Liao, Ching-Kuan Wu, Chih-Min Liu, Yu-Li Liu, Hai-Gwo Hwu, I-Ching Lai, Shih-Jen Tsai, Chia-Hsiang Chen, Hui-Fen Liu, Yi-Chun Chou, Chien-Hsiun Chen, Yuan-Tsong Chen, Chen-Jee Hong, Jer-Yuarn Wu   +22 more
doaj   +1 more source

The promoter polymorphism of NFKB1 gene contributes to susceptibility of ischemic stroke in Korean population [PDF]

Journal of Exercise Rehabilitation, 2018
The progression of ischemic stroke is associated with inflammatory response, in which the nuclear factor kappa B subunit 1 (NFKB1) plays an important role. The aim of present study was to determine whether promoter single nucleotide polymorphism (SNP) in the NFKB1 gene was contributed to susceptibility of ischemic stroke.
Su Kang Kim, Hyang Mi Jang, Dae-Young Kim   +2 more
openaire   +3 more sources

The Potential Role of Egg‐Derived Xeno‐miRs in Chemotherapy Response: An In Silico Approach

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Dietary microRNAs (Xeno‐miRs), especially those homologous to human miRNAs found in animal‐based foods, may influence chemotherapy responses across cancer types. This study highlights the underexplored potential of human homolog egg‐derived Xeno‐miRs as biomarkers and therapeutic targets.
Berkcan Doğan
wiley   +1 more source

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

Glia, Volume 73, Issue 6, Page 1166-1187, June 2025.
Main Points Generation and characterization of iPSC‐derived astrocytes from 44 aged humans. Congruence of gene expression profiles between astrocyte cultures and brain. Association of interferon response proteins with AD pathology resilience. ABSTRACT Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants
Hyo Lee, Richard V. Pearse II, Alexandra M. Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioglu, Pallavi Gaur, Meichen Liao, Masashi Fujita, Earvin S. Tio, Duc M. Duong, Daniel Felsky, Nicholas T. Seyfried, Vilas Menon, David A. Bennett, Philip L. De Jager, Tracy L. Young‐Pearse   +16 more
wiley   +1 more source

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems [PDF]

, 2012
Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria and the insulin signaling ...
, , Bonàs-Guarch, Sílvia, Draghici, Sorin, Dupuis, Josée, Florez, Jose C., Mercader, Josep M., Mora, Sílvia, Planet, Evarist, Puiggros, Montserrat, Ribas, Vicent, Rodriguez-Cuenca, Sergio, Sebastian, David, Segrè, Ayellet V., Sorianello, Eleonora, Torrents, David, Vidal-Puig, Antoni, Yang, Chenjing, Zorzano, Antonio   +18 more
core   +3 more sources

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

Loss of function NFKB1 variants are the most common monogenic cause of CVID in Europeans [PDF]

, 2018
BACKGROUND: The genetic etiology of primary immunodeficiency disease (PID) carries prognostic information. OBJECTIVE: We conducted a whole-genome sequencing study assessing a large proportion of the NIHR-BioResource - Rare Disease cohort. METHODS: In the
Baxendale, H, Biasci, D, Brown, M, Burns, SO, Carss, KJ, Chandra, A, de Bree, GJ, Ebberink, EHTM, Greene, D, Jansen, MH, Kiani-Alikhan, S, Kuijpers, TW, Lango Allen, H, Longhurst, HJ, Meijer, AB, NIHR-BioResource – Rare Diseases Consortium, ., Oksenhendler, E, Seneviratne, SL, Simeoni, I, Smith, KGC, Staples, E, Stephens, J, Thaventhiran, JE, Thomas, M, Thrasher, AJ, Tool, ATJ, Tuijnenburg, P, Tuna, S, Turro, E, van Leeuwen, EMM, Whitehorn, D   +30 more
core  

Interactions between meat intake and genetic variation in relation to colorectal cancer [PDF]

, 2014
Supplementary material 1 (DOCX 46 ...
Andersen, Vibeke, Vogel, Ulla
core   +2 more sources

Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
ADAP1/CentA1 is an actin‐binding protein highly expressed in neurons. Our study describes a novel immunomodulatory function for ADAP1/CentA1 in the context of autoimmune demyelination. Mice lacking ADAP1/CentA1 were found partially resistant to the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE) due to an altered ...
Jonathan J. Carver, Wyatt P. Bunner, Rachael R. Denbrock, Changhong Yin, Weihua Huang, Erzsebet M. Szatmari, Alessandro Didonna   +6 more
wiley   +1 more source