Results 111 to 120 of about 21,043 (239)

A Unique Plasma Protein Signature Characterizes Squamous Cell Carcinoma of the Oral Tongue in Young Adults

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background The incidence of squamous cell carcinoma of the oral tongue (SCCOT) among young adults is increasing in several regions of the world. Age‐dependent differences in the biology of SCCOT have been suspected. Methods We used the Olink Explore 3072 high‐throughput platform to comprehensively quantify plasma proteins in 24 young (≤ 40 ...
Xiaolian Gu, Philip J. Coates, Lixiao Wang, Sivakumar Vadivel Gnanasundram, Nicola Sgaramella, Nima Attaran, Baris Erdogan, Mustafa Magan, Karin Nylander   +8 more
wiley   +1 more source

ASSOCIATION OF EXPRESSION OF NFKB1, HIF1, VEGFA, VEGFВ, BAX, BCL2 GENES WITH BIOCHEMICAL REMEDIATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER

Исследования и практика в медицине, 2019
Aim. To identify the association of NFKB1, HIF1, VEGFA, VEGFB, BAX, BCL2 gene expression in prostate adenocarcinoma cells with biochemical recurrence of localized prostate cancer.Patients and methods.
Ph. S. Bova, O. I. Kit, A. Yu. Maksimov
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Механизмы инактивации активированных кислородсодержащих метаболитов антиоксидантной системой респираторного тракта [PDF]

, 2017
В обзоре литературы изложены современные данные о вкладе различных механизмов антиоксидантной системы респираторного тракта в процесс инактивации активированных кислородсодержащих метаболитов и дана характеристика окислительно-восстановительных реакций ...
Абатуров, А.Е., Борисова, Т.П., Волосовец, А.П.   +2 more
core   +1 more source

Addressing Anemia in High‐Altitude Populations: Global Impact, Prevalence, Challenges, and Potential Solutions

American Journal of Hematology, Volume 100, Issue 9, Page 1590-1602, September 2025.
Key challenges in diagnosing anemia in high‐altitude populations include variability in hemoglobin (Hb) concentration, associated pathological conditions, altitude‐induced plasma volume changes, and environmental factors such as contamination and nutrition.
Ayoub Boulares, Nicola Luigi Bragazzi, Gustavo F. Gonzales, Paul Robach, Benoit Champigneulle, Julien V. Brugniaux, Emeric Stauffer, Elie Nader, Stéphane Doutreleau, Philippe Connes, Samuel Verges, Aurélien Pichon   +11 more
wiley   +1 more source

A polymorphism in NFKB1 is associated with improved effect of interferon-α maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support

Haematologica, 2009
Background Maintenance therapy with interferon-α after high-dose treatment with stem cell support in multiple myeloma has been intensively debated. In this study, we evaluated the response to treatment with interferon-α in relation to genetic variation ...
Annette J. Vangsted, Tobias W. Klausen, Peter Gimsing, Niels F. Andersen, Niels Abildgaard, Henrik Gregersen, Ulla Vogel   +6 more
doaj   +1 more source

IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen [PDF]

, 2014
The importance of IκB kinase (IKK)–induced proteolysis of NF-κB1 p105 in B cells was investigated using Nfkb1SSAA/SSAA mice, in which this NF-κB signaling pathway is blocked.
Alexander Visekruna, Basso, Beinke, Beinke, Buggins, Cyster, Damdinsuren, David M. Tarlinton, De Silva, Derudder, Dumitru, Edina Schweighoffer, Emilie Jacque, Gatto, Gavin, Gerondakis, Gerondakis, Ghosh, Glynne, Goodnow, Goodnow, Grossmann, Grumont, Grumont, Grumont, Grumont, Hettmann, Huntington, Ishikawa, Julia Janzen, Kabouridis, Kaileh, Kallies, Karin, Kelly, Kitamura, Klein, Krappmann, Kravtsova-Ivantsiv, Köntgen, Lang, Li, Mackay, Mason, Mombaerts, Moorthy, Morgan, Ochiai, Oracki, Pasparakis, Peperzak, Pereira, Pereira, Pillai, Pohl, Rachel Zillwood, Reif, Rickert, Robinson, Saito, Salmerón, Savinova, Sciammas, Sha, Shaffer, Solan, Sriskantharajah, Stamatia Papoutsopoulou, Steven C. Ley, Takahashi, Tanigaki, Turner, Victor L.J. Tybulewicz, Waterfield, Yang, Yuseff, Zhang   +76 more
core   +1 more source

Sirtuin 2 regulates NOD‐like receptor protein 3/nuclear factor kappa B axis to promote cartilage repair in osteoarthritis

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Schematic diagram illustrating the molecular mechanism by which sirtuin 2 promotes cartilage damage repair in OA through deacetylation, inhibiting the NOD‐like receptor protein 3/nuclear factor kappa B axis. Abstract Osteoarthritis (OA) is a prevalent degenerative joint disease driven by inflammation and cartilage degradation.
Xiaotian Chen, Yining Song, Fan Zhang, Fangyan Hu, Zhenfei Ding, Jianzhong Guan   +5 more
wiley   +1 more source

Nuclear factor-kappa B in the liver of patients with chronic hepatitis C: decreased RelA expression is associated with enhanced fibrosis progression [PDF]

, 2001
The mechanisms of liver damage in chronic hepatitis C virus (HCV) infection are poorly understood. The transcription factor, nuclear factor-kappa B (NF-kappa B), regulates the expression of genes involved in apoptosis, inflammation, and antiviral ...
Boya, P. (Patricia), Civeira, M.P. (María Pilar), Jimenez, C. (Carlos), Larrea, E. (Esther), Majano, P.L. (Pedro Lorenzo), Prieto, J. (Jesús), Sola, J. (Josu)   +6 more
core   +1 more source

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, Volume 73, Issue 9, Page 1817-1840, September 2025.
Main Point Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source