Results 121 to 130 of about 21,043 (239)

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Loss of function NFKB1 variants are the most common monogenic cause of CVID in Europeans [PDF]

, 2018
BACKGROUND: The genetic etiology of primary immunodeficiency disease (PID) carries prognostic information. OBJECTIVE: We conducted a whole-genome sequencing study assessing a large proportion of the NIHR-BioResource - Rare Disease cohort. METHODS: In the
Baxendale, H, Biasci, D, Brown, M, Burns, SO, Carss, KJ, Chandra, A, de Bree, GJ, Ebberink, EHTM, Greene, D, Jansen, MH, Kiani-Alikhan, S, Kuijpers, TW, Lango Allen, H, Longhurst, HJ, Meijer, AB, NIHR-BioResource – Rare Diseases Consortium, ., Oksenhendler, E, Seneviratne, SL, Simeoni, I, Smith, KGC, Staples, E, Stephens, J, Thaventhiran, JE, Thomas, M, Thrasher, AJ, Tool, ATJ, Tuijnenburg, P, Tuna, S, Turro, E, van Leeuwen, EMM, Whitehorn, D   +30 more
core  

TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. [PDF]

, 2019
Macrophages are a reservoir for latent human immunodeficiency type 1 (HIV) infection and a barrier to HIV eradication. In contrast to CD4+ T cells, macrophages are resistant to the cytopathic effects of acute HIV infection.
Abbas, Abbas, Abbas, Altay, Bergemann, Bleharski, Boliar, Bouchon, Bouchon, Bullen, Campbell, Campbell, Campbell, Campbell, Campbell, Castellano, Chen, Clayton, Cory, de Mareuil, Denner, Duncan, El Mezayen, Frankfurt, Ganor, Gartner, Guillemard, Hara, Haselmayer, Honeycutt, Honeycutt, Hyun, Igarashi, Japour, Jobe, Jobe, Kozik, Laird, Leboucher, Lei, López-Huertas, Mohamadzadeh, Netea, Pelham, Puthalakath, Pyakurel, Radsak, Ratner, Ruiz-Pacheco, Shan, Singh, Spivak, Suthar, Swingler, Verma, Walker-Sperling, Wauquier, Wei, Wolf, Wong-Baeza, Yang, Yuan, Yuan, Zeng   +63 more
core   +2 more sources

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional VariantsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Primary biliary cholangitis (PBC) is a chronic and cholestatic liver disease that eventually leads to cirrhosis and hepatic failure. We recently identified several susceptibility genes included NFKB1 and MANBA for PBC in the Japanese ...
Yuki Hitomi, Ken Nakatani, Kaname Kojima, Nao Nishida, Yosuke Kawai, Minae Kawashima, Yoshihiro Aiba, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga   +9 more
doaj  

Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways [PDF]

, 2015
The molecular basis of cancer and cancer multiple phenotypes are not yet fully understood. Next Generation Sequencing promises new insight into the role of genetic interactions in shaping the complexity of cancer.
Ahuja, Al-Halabi, Albrethsen, Andersen, Bodmer, Brosens, Cerami, Challis, Chen, Chen, Chou, Courtois, Djavaheri-Mergny, Doncheva, Emmert-Streib, Fan, Fearson, Gallois-Montbrun, Glaab, Glusman, González-Pérez, Hendon, Hoesel, Hudson, Huhn, Ignatenko, Jiao, Jones, Karin, Kemp, Kim, Kim, Koduru, Kolde, Kolligs, Kreeger, Li, Li, Lim, Luisi, López de Silanes, MacDonald, Maere, March, Masri, McKenna, Moorchung, Muramatsu, Niimura, O’Bryan, Paz, R Core Team, Rayet, Robbiani, Roberts, Rosenfeld, Shannon, Shi, Shultz, Tang, The Cancer Genome Atlas Network, van Engeland, VanBuren, Venables, Wallmen, Wang, Wang, Warde-Farley, Winkler, Wu, Yahia, Yang, Yiakouvaki, Young, Yu, Zhang, Zhou   +76 more
core   +2 more sources

Discovering new hub genes of dilated cardiomyopathy

ESC Heart Failure, Volume 12, Issue 4, Page 2487-2498, August 2025.
Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
wiley   +1 more source

NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis

Tumor Biology, 2014
Previous studies on the associations of the NFKB1 -94 insertion/deletion polymorphism with cancer risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of the NFKB1 -94 insertion/deletion polymorphism on cancer risk.
Zhichun Song, Wei Chen, Shao Yi Huang, Linlin Xu, Shu Cai   +4 more
openaire   +2 more sources

Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus.

PLoS ONE, 2020
Inflammation has received considerable attention in the pathogenesis of type 2 diabetes mellitus (T2DM). Supporting this concept, enhanced expression of interleukin (IL)-1β and increased infiltration of macrophages are observed in pancreatic islets of ...
Sona Margaryan, Eva Kriegova, Regina Fillerova, Veronika Smotkova Kraiczova, Gayane Manukyan   +4 more
doaj   +1 more source

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Glia, Volume 73, Issue 8, Page 1627-1641, August 2025.
Main Points FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte‐mediated neurotoxicity. FABP7 silencing attenuates NF‐κB‐dependent transcriptional response during endotoxemia. ABSTRACT Fatty acid binding proteins (FABPs) are a family of small proteins involved in fatty acid (FA) subcellular trafficking.
Mariana Bresque, Daniel Esteve, Garret Balmer, Haylee L. Hamilton, Joshua S. Stephany, Mariana Pehar, Marcelo R. Vargas   +6 more
wiley   +1 more source