Results 121 to 130 of about 20,241 (230)

A polymorphism in NFKB1 is associated with improved effect of interferon-α maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support

Haematologica, 2009
Background Maintenance therapy with interferon-α after high-dose treatment with stem cell support in multiple myeloma has been intensively debated. In this study, we evaluated the response to treatment with interferon-α in relation to genetic variation ...
Annette J. Vangsted, Tobias W. Klausen, Peter Gimsing, Niels F. Andersen, Niels Abildgaard, Henrik Gregersen, Ulla Vogel   +6 more
doaj   +1 more source

Exome analysis of rare and common variants within the NOD signaling pathway [PDF]

, 2017
Pediatric inflammatory bowel disease (pIBD) is a chronic heterogeneous disorder. This study looks at the burden of common and rare coding mutations within 41 genes comprising the NOD signaling pathway in pIBD patients.
Afzal, Nadeem A., Andreoletti, Gaia, Batra, Akshay, Beattie, R. Mark, Christenson, Kathy, Coelho, Tracy, Ennis, Sarah, Haggarty, Rachel, Mort, Matthew, Petersen, Britt-Sabina, Shakhnovich, Valentina   +10 more
core   +1 more source

NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional VariantsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Primary biliary cholangitis (PBC) is a chronic and cholestatic liver disease that eventually leads to cirrhosis and hepatic failure. We recently identified several susceptibility genes included NFKB1 and MANBA for PBC in the Japanese ...
Yuki Hitomi, Ken Nakatani, Kaname Kojima, Nao Nishida, Yosuke Kawai, Minae Kawashima, Yoshihiro Aiba, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga   +9 more
doaj  

Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus.

PLoS ONE, 2020
Inflammation has received considerable attention in the pathogenesis of type 2 diabetes mellitus (T2DM). Supporting this concept, enhanced expression of interleukin (IL)-1β and increased infiltration of macrophages are observed in pancreatic islets of ...
Sona Margaryan, Eva Kriegova, Regina Fillerova, Veronika Smotkova Kraiczova, Gayane Manukyan   +4 more
doaj   +1 more source

Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways [PDF]

, 2015
The molecular basis of cancer and cancer multiple phenotypes are not yet fully understood. Next Generation Sequencing promises new insight into the role of genetic interactions in shaping the complexity of cancer.
Ahuja, Al-Halabi, Albrethsen, Andersen, Bodmer, Brosens, Cerami, Challis, Chen, Chen, Chou, Courtois, Djavaheri-Mergny, Doncheva, Emmert-Streib, Fan, Fearson, Gallois-Montbrun, Glaab, Glusman, González-Pérez, Hendon, Hoesel, Hudson, Huhn, Ignatenko, Jiao, Jones, Karin, Kemp, Kim, Kim, Koduru, Kolde, Kolligs, Kreeger, Li, Li, Lim, Luisi, López de Silanes, MacDonald, Maere, March, Masri, McKenna, Moorchung, Muramatsu, Niimura, O’Bryan, Paz, R Core Team, Rayet, Robbiani, Roberts, Rosenfeld, Shannon, Shi, Shultz, Tang, The Cancer Genome Atlas Network, van Engeland, VanBuren, Venables, Wallmen, Wang, Wang, Warde-Farley, Winkler, Wu, Yahia, Yang, Yiakouvaki, Young, Yu, Zhang, Zhou   +76 more
core   +2 more sources

Involvement of nuclear factor kappa-B in development of neonatal onset multisystem inflammatory disease

Journal of King Saud University: Science, 2020
The present study investigated the relationship between nuclear factor-κB1 gene (NFkB1) and neonatal onset multisystem inflammatory disease (NOMID) among Chinese neonates.
Fei Yu, Min Chen, Li Zhou
doaj  

NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis

Tumor Biology, 2014
Previous studies on the associations of the NFKB1 -94 insertion/deletion polymorphism with cancer risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of the NFKB1 -94 insertion/deletion polymorphism on cancer risk.
Zhichun Song, Wei Chen, Shao Yi Huang, Linlin Xu, Shu Cai   +4 more
openaire   +2 more sources

mRNA Expression of GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 Transcription Factors in Humans and Their Cooperative Interactions Long-Term after Exposure to Chronic Radiation [PDF]

, 2022
В. С. Никифоров, А. V. Akleyev   +1 more
openalex   +1 more source

Identification of new DNA markers of endometrial cancer in patients from the Ukrainian population [PDF]

, 2007
Aim: To identify clinically significant molecular markers of endometrial cancer. Materials and Methods: Cancer and normal endometrial tissue samples from 20 patients of the Gynecology Clinic of Odessa State Medical University (Odessa, Ukraine) with ...
Bubnov, V.V., Domenyuk, V.P., Dubinina, V.G., Litovkin, K.V., Verbitskaya, T.G.   +4 more
core  

Integrated Multi-omics Analyses of NFKB1 patients B cells points towards an up regulation of NF-κB network inhibitors [PDF]

, 2022
Nadezhda Camacho-Ordóñez, Neftali Jose Ramirez, Sara Posadas‐Cantera, Andrés Caballero-Oteyza, Manfred Fliegauf, Fangwen Zhao, Maria Guarini, Victoria Gernedl, Mateo Pecoroaro, Klaus Warnatz, Christoph Bock, Esteban Ballestar, Roger Geiger, Michele Proietti, Bodo Grimbacher   +14 more
openalex   +1 more source