Results 141 to 150 of about 23,374 (217)

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, Volume 25, Issue 1, January 2026.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Transcription factor NFKB1 mediates TUBB6 to promote the proliferation and suppress apoptosis in glioma via Wnt/β-catenin signaling pathway

Discover Oncology
Glioma remains one of the most challenging brain tumors with poor prognosis. In this study, we aimed to elucidate the role of TUBB6 in glioma and its potential as a diagnostic and prognostic biomarker.
Yan Li, Ziyu Shao, Jun Jiang, Hongyan Wang, Mei Zhang   +4 more
doaj   +1 more source

Coxiella burnetii and Leishmania Mexicana Residing Within Similar Parasitophorous Vacuoles Elicit Disparate Host Responses [PDF]

, 2015
Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes. Leishmania mexicana, a eukaryote, has also independently evolved to live in a morphologically similar PV.
Cambronne, Eric D., Kacharia, Fenil, Landfear, Scott M., Malchiodi, Emilio Luis, Millar, Jess A., Raghavan, Rahul, Soong, Lynn, Valdés, Raquel   +7 more
core   +1 more source

Loss of p62 Binding Allows TIF‐IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype

Aging Cell, Volume 25, Issue 1, January 2026.
P62‐TIF‐IA–mediated regulation of senescence and ageing. In healthy tissue, p62 facilitates TIF‐IA turnover. Upon senescence induction, ATM activation increases TIF‐IA phosphorylation at S44, reducing its p62 binding and causing TIF‐IA accumulation.
Hazel C. Thoms, Tyler S. Brant, Katie Duckett, Yizheng Yang, Jinxi Dong, Hongfei Wang, Freya Derby, Oluwatumilara F. Akeke, Faizah Al‐Alayeen, Amy Newell, Piotr Manasterski, Aishwarya Gopalakrishnan, Derek Mann, Fraser R. Millar, Alex Von Kriegsheim, Juan Carlos Acosta, Fiona Oakley, Lesley A. Stark   +17 more
wiley   +1 more source

NFKB1 Gene [PDF]

, 2020
openaire   +1 more source

NFKB1 Gene Product [PDF]

, 2020
openaire   +1 more source

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Background Coronary heart disease (CHD) is a leading cause of cardiovascular mortality worldwide, with its pathogenesis being complex and not yet fully understood. The rapid development of genomics, especially in epigenetic research, has provided essential tools for identifying new pathogenic targets. This study is aimed at systematically exploring the
Junchi Guo, Fang Huang, Peihan Lu, Meijuan Lu, Arquimedes Gasparotto Junior   +4 more
wiley   +1 more source

Identification and construction of prognostic clusters and risk-prognosis model based on aging-immune related genes in bladder cancer

Discover Oncology
Background Faced with the current global ageing situation, advanced age has become a risk factor for bladder carcinogenesis progression and immunotherapy.
Nihao Cao, Fei Cheng, Jincai Zhou, Ning Liu   +3 more
doaj   +1 more source

NFKB1 ile özgül mikroRNA genlerindeki varyasyonların aterosklerozla ilişkisinin incelenmesi

, 2020
Atherosclerosis, a common and complex disease, is a chronic immuno-inflammatory disease characterized by inflammatory mediators and immune activation in arterial wall. MicroRNAs and NF-KB are involved in the regulation of a variety of biological processes, such as inflammation and immune responses.
openaire   +1 more source

A genetikai (ATG16L1, IL23R és NFKB) és klinikai faktorok szerepe a gyulladásos bélbetegségek pathogenezisében és lefolyásában [PDF]

, 2014
Szamosi, Tamás
core   +1 more source