Nfkb1 suppresses DNA alkylation-induced tumor formation [PDF]
Molecular & Cellular Oncology, 2015 NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor ...
Bakhtiar Yamini, Adam M. Schmitt
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The nfkb1 promoter is controlled by proteins of the Ets family. [PDF]
Molecular Biology of the Cell, 1997 The gene encoding NFKB1 is autoregulated, responding to NF-kappa B/Rel activation through NF-kappa B binding sites in its promoter, which also contains putative sites for Ets proteins. One of the Ets sites, which we refer to as EBS4, is located next to an NF-kappa B/Rel binding site, kB3, which is absolutely required for activity of the promoter in ...
Paul Lambert +4 more
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Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population [PDF]
, 2012 BACKGROUND: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes ...
A Comandini +76 more
core +25 more sources
MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis [PDF]
Scientific Reports, 2021 Toll-like receptor (TLR) family signature has been implicated in sepsis etiopathology. We aimed to evaluate the genetic profile of TLR pathway-related key genes; the myeloid differentiation protein 88 (MYD88), IL1 receptor-associated kinase 1 (IRAK1 ...
Nouran B. AbdAllah +6 more
doaj +2 more sources
A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study [PDF]
Cancer Medicine, 2018 Genetic variations of NF‐κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cancer ...
Fa Chen +10 more
doaj +2 more sources
A Functional Polymorphism of the NFKB1 Promoter Is Not Associated with Ulcerative Colitis in a Spanish Population [PDF]
Inflammatory Bowel Diseases, 2005 This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis.We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern Spain by a polymerase chain reaction-fluorescent method.The genotype and allele frequencies of -94ins/delATTG did not ...
Oliver, Francisco Javier +9 more
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Functional promoter -94 ins/del ATTG polymorphism in NFKB1 gene is associated with bladder cancer risk in a Chinese population. [PDF]
PLoS ONE, 2013 BACKGROUND: A functional -94 insertion/deletion polymorphism (rs28362491) in the promoter of the NFKB1 gene was reported to influence NFKB1 expression and confer susceptibility to different types of cancer.
Pengchao Li +9 more
doaj +3 more sources
Oncotarget, 2015 Aging is a progressive process that involves a combination of genetic and acquired factors that ultimately cause loss of tissue homeostasis and death. Among the pathways that modulate aging, NF-κ B has been shown to play a central role [1]. Interestingly, the majority of studies examining NF-κB and aging suggest that this transcription factor promotes ...
Bakhtiar Yamini
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Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis [PDF]
, 2008 Many studies have implicated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-κB1 (Nfkb1) in inflammation and cancer. However, the regulatory potential for crosstalk between these two important transcription factors in inflammation and ...
A Barve +61 more
core +4 more sources
Genetic Analyses of NFKB1 and OCA-B Function: Defects in B Cells, Serum IgM Level, and Antibody Responses in Nfkb1−/−Oca-b−/− Mice [PDF]
The Journal of Immunology, 2000 Abstract Defined patterns of gene expression during cell differentiation are likely to be ensured by multiple factors playing redundant roles. By generating mice deficient in both NFKB1 and OCA-B, we show here that the two transcription factors are required for B-1 cell differentiation and serum IgM production.
Robert G. Roeder +2 more
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