Results 11 to 20 of about 21,043 (239)

NFKB1 and Cancer: Friend or Foe? [PDF]

Cells, 2018
Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway is associated with carcinogenesis. A number of key cellular processes are governed by the effectors of this pathway, including immune responses and ...
Julia Concetti, Caroline L. Wilson
doaj   +5 more sources

NFKB1 regulates human NK cell maturation and effector functions [PDF]

Clinical Immunology, 2017
12siopenopenLougaris, Vassilios; Patrizi, Ornella; Baronio, Manuela; Tabellini, Giovanna; Tampella, Giacomo; Damiati, Eufemia; Frede, Natalie; van der Meer, Jos W.M.; Fliegauf, Manfred; Grimbacher, Bodo; Parolini, Silvia; Plebani, AlessandroLougaris ...
Baronio, M., Damiati, E., Fliegauf, M., Frede, N., Grimbacher, B., Lougaris, V., Meer, J.W.M. van der, Parolini, S., Patrizi, O., Plebani, A., Tabellini, G., Tampella, G.   +11 more
core   +8 more sources

The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson’s disease

Journal of Neuroinflammation
Background Overactivated microglia are a key contributor to Parkinson’s disease (PD) by inducing neuroinflammation. CD200R1, a membrane glycoprotein mainly found on microglia, is crucial for maintaining quiescence with its dysregulation linked to ...
Suzhen Lin, Yimei Shu, Ruinan Shen, Yifan Zhou, Hong Pan, Lu He, Fang Fang, Xue Zhu, Xinrui Wang, Ying Wang, Wei Xu, Jianqing Ding   +11 more
doaj   +3 more sources

A novel NFKB1 variant in a Japanese pedigree with common variable immunodeficiency

Human Genome Variation
Recently, heterozygous loss-of-function NFKB1 variants were identified as the primary cause of common variable immunodeficiency (CVID) in the European population. However, pathogenic NFKB1 variants have never been reported in the Japanese population.
Naoko Nakatani, Akihiro Tamura, Hiroaki Hanafusa, Nanako Nino, Nobuyuki Yamamoto, Hiroyuki Awano, Yasuhiro Tanaka, Naoya Morisada, Suguru Uemura, Atsuro Saito, Daiichiro Hasegawa, Kandai Nozu, Yoshiyuki Kosaka   +12 more
doaj   +3 more sources

Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features. [PDF]

PLoS ONE, 2013
Constitutive activation of nuclear factor (NF)-κB is frequently observed in hepatocellular carcinoma (HCC). The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the ...
Chao-Wen Cheng, Jen-Liang Su, Chiao-Wen Lin, Chun-Wen Su, Chun-Han Shih, Shun-Fa Yang, Ming-Hsien Chien   +6 more
doaj   +4 more sources

The nfkb1 promoter is controlled by proteins of the Ets family. [PDF]

Molecular Biology of the Cell, 1997
The gene encoding NFKB1 is autoregulated, responding to NF-kappa B/Rel activation through NF-kappa B binding sites in its promoter, which also contains putative sites for Ets proteins. One of the Ets sites, which we refer to as EBS4, is located next to an NF-kappa B/Rel binding site, kB3, which is absolutely required for activity of the promoter in ...
Paul F. Lambert, M J Ludford-Menting, Nicholas J. Deacon, I. Kola, Richard Doherty   +4 more
openalex   +5 more sources

Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy [PDF]

BMC Medical Genetics, 2009
Background Previous studies in experimental and human heart failure showed that nuclear factor kappa B (NF-κB) is chronically activated in cardiac myocytes, suggesting an important involvement of NF-κB in the cardiac remodeling process.
Song Yaping, Xue Hui, Chen Yu, Gao Linbo, Li Yi, Wang Yanyun, Peng Ying, Rao Li, Zhou Bin, Liao Miao, Zhang Lin   +10 more
doaj   +4 more sources

Nfkb1 suppresses DNA alkylation-induced tumor formation [PDF]

Molecular & Cellular Oncology, 2015
NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor ...
Adam M. Schmitt, Bakhtiar Yamini
openalex   +4 more sources

A Functional Polymorphism of the NFKB1 Promoter Is Not Associated with Ulcerative Colitis in a Spanish Population [PDF]

Inflammatory Bowel Diseases, 2005
This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis.We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern Spain by a polymerase chain reaction-fluorescent method.The genotype and allele frequencies of -94ins/delATTG did not ...
Javier Oliver, María Gómez–García, Laura Paco, Miguel Ángel López‐Nevot, Alexis Piñero, Francisco Correro, Leopoldo Martín, José A. Brieva, Antonio Nieto, Javier Martı́n   +9 more
openalex   +5 more sources

Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy [PDF]

Journal of Clinical Investigation, 2004
The intracellular signals that mediate skeletal muscle protein loss and functional deficits due to muscular disuse are just beginning to be elucidated. Previously we showed that the activity of an NF-kappaB-dependent reporter gene was markedly increased in unloaded muscles, and p50 and Bcl-3 proteins were implicated in this induction.
R. Bridge Hunter, Susan C. Kandarian
openalex   +3 more sources