Results 11 to 20 of about 23,374 (217)

NFKB1 regulates human NK cell maturation and effector functions [PDF]

Clinical Immunology, 2017
12siopenopenLougaris, Vassilios; Patrizi, Ornella; Baronio, Manuela; Tabellini, Giovanna; Tampella, Giacomo; Damiati, Eufemia; Frede, Natalie; van der Meer, Jos W.M.; Fliegauf, Manfred; Grimbacher, Bodo; Parolini, Silvia; Plebani, AlessandroLougaris ...
Baronio, M., Damiati, E., Fliegauf, M., Frede, N., Grimbacher, B., Lougaris, V., Meer, J.W.M. van der, Parolini, S., Patrizi, O., Plebani, A., Tabellini, G., Tampella, G.   +11 more
core   +7 more sources

Late-Onset Antibody Deficiency Due to Monoallelic Alterations in NFKB1 [PDF]

Frontiers in Immunology, 2019
Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody ...
Claudia Schröder, Claudia Schröder, Georgios Sogkas, Manfred Fliegauf, Manfred Fliegauf, Thilo Dörk, Di Liu, Leif G. Hanitsch, Sophie Steiner, Carmen Scheibenbogen, Roland Jacobs, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Reinhold E. Schmidt, Reinhold E. Schmidt, Reinhold E. Schmidt, Reinhold E. Schmidt, Faranaz Atschekzei, Faranaz Atschekzei   +20 more
doaj   +4 more sources

NFKB1 and Cancer: Friend or Foe? [PDF]

Cells, 2018
Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway is associated with carcinogenesis. A number of key cellular processes are governed by the effectors of this pathway, including immune responses and ...
Julia Concetti, Caroline L. Wilson
doaj   +4 more sources

A novel NFKB1 variant in a Japanese pedigree with common variable immunodeficiency

Human Genome Variation
Recently, heterozygous loss-of-function NFKB1 variants were identified as the primary cause of common variable immunodeficiency (CVID) in the European population. However, pathogenic NFKB1 variants have never been reported in the Japanese population.
Naoko Nakatani, Akihiro Tamura, Hiroaki Hanafusa, Nanako Nino, Nobuyuki Yamamoto, Hiroyuki Awano, Yasuhiro Tanaka, Naoya Morisada, Suguru Uemura, Atsuro Saito, Daiichiro Hasegawa, Kandai Nozu, Yoshiyuki Kosaka   +12 more
doaj   +3 more sources

Nfkb1/p50 and mammalian aging [PDF]

Oncotarget, 2015
Aging is a progressive process that involves a combination of genetic and acquired factors that ultimately cause loss of tissue homeostasis and death. Among the pathways that modulate aging, NF-κ B has been shown to play a central role [1]. Interestingly, the majority of studies examining NF-κB and aging suggest that this transcription factor promotes ...
Giovanna M, Bernal, Joshua S, Wahlstrom, Clayton D, Crawley, Kirk E, Cahill, Peter, Pytel, Hua, Liang, Shijun, Kang, Ralph R, Weichselbaum, Bakhtiar, Yamini   +8 more
  +7 more sources

A novel NFkB1 mutation linking pyoderma gangrenosum and common variable immunodeficiency [PDF]

JAAD Case Reports, 2021
Pyoderma gangrenosum (PG) is a sterile neutrophilic dermatosis manifesting as painful inflammatory plaques and ulcers, frequently associated with inflammatory bowel disease, rheumatoid arthritis, myelodysplastic syndrome, and acute myeloid leukemia.1 We present a case of a young woman with a novel mutation in NFkB1 who experienced common variable ...
Qisi Sun, MD, Jeff R. Gehlhausen, MD, PhD, Marianna Freudzon, MD, Nour Kibbi, MD, Allen Bale, MD, Keith Choate, MD, PhD, Mary Tomayko, MD, PhD, Ian Odell, MD, PhD, Sarika Ramachandran, MD   +8 more
openaire   +3 more sources

Nfkb1 suppresses DNA alkylation-induced tumor formation [PDF]

Molecular & Cellular Oncology, 2015
NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor ...
Schmitt, Adam M, Yamini, Bakhtiar
openaire   +2 more sources

Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population [PDF]

, 2020
Objectives: The cause of Meniere's disease (MD) is unclear but likely involves genetic and environmental factors. The aim of this study was to investigate the genetic basis underlying MD by screening putative candidate genes for MD.
Arweiler-Harbeck, Begovich, Brama, Cabrera, Campbell, de Lima, Doi, Dong, Eichler, Filipo, Flook, Foster, Frejo, Frejo, Frejo, Furuta, Gallego-Martinez, Gazquez, Gazquez, Girirajan, Greco, Hietikko, Huang, Kawaguchi, Khorsandi, Kim, Kimura, Klar, Koo, Lee, Lee, Lee, Lee, Lettre, Li, Li, Lien, Lien, Liew, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Marcus, Martín-Sierra, Martín-Sierra, Melchiorri, Meng, Morrison, Mustelin, Nair, Nair, Nair, Nishio, Oliveira-Paula, Qin, Rasheed, Rauch, Recupero, Reich, Rentzsch, Requena, Requena, Requena, Requena, Roman-Naranjo, Saint Pierre, Schwanitz, Shu, Sun, Takumida, Teggi, Teggi, Teggi, Teranishi, Tilburg, Tomoda, Uchida, Vrabec, Yang, Yazdani, Yazdani   +81 more
core   +1 more source

Herbal combination from Moringa oleifera Lam. and Curcuma longa L. as SARS-CoV-2 antiviral via dual inhibitor pathway: A viroinformatics approach. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: The COVID-19 outbreak is caused by the transmission and infection of SARS-CoV-2 at the end of 2019. It has led many countries to implement lockdown policies to prevent the viral spreading.
Viol Dhea Kharisma, Aggy Agatha, Arif Nur Muhammad Ansori, Muhammad Hermawan Widyananda, Wahyu Choirur Rizky, Tim Godefridus Antonius Ding, Marina Derkho, Irina Lykasova, Yulanda Antonius, Imam Rosadi, Rahadian Zainul   +10 more
doaj  

SV2B Promotes the Progression of TFE3-Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF-κB Subunits. [PDF]

Adv Sci (Weinh)
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) lacks clearly defined diagnostic and therapeutic targets. SV2B, a TFE3 target gene, promotes TFE3‐RCC progression by activating the NF‐κB pathway. Targeted inhibition with padsevonil or Withaferin A effectively suppresses tumor progression.
Feng H, Xiong Z, Yu S, Liu J, Cao S, Liu K, Huang X, Wen L, Wang B, Huang Q, Pan T, Zhang X, Ma X, Li X.   +13 more
europepmc   +2 more sources