Results 211 to 220 of about 20,241 (230)

Advancing the understanding and management of Mpox: insights into epidemiology, disease pathways, prevention, and therapeutic strategies. [PDF]

BMC Infect Dis
Hajjo R, Abusara OH, Sabbah DA, Bardaweel SK.   +3 more
europepmc   +1 more source

Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis [PDF]

Human Molecular Genetics, 2004
Nuclear Factor-kappaB (NF-kappaB) is a major transcription regulator of immune response, apoptosis and cell-growth control genes, and is upregulated in inflammatory bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease. The NFKB1 gene encodes the NF-kappaB p105/p50 isoforms.
Peter K. Gregersen, Mark S. Silverberg, Themistocles Dassopoulos, Yuqiong Wu, Amir Karban, James J. Potter, Richard H. Duerr, Esteban Mezey, Theodore M. Bayless, Carolien I.M. Panhuysen, Joan E. Bailey-Wilson, Thomas Gallegos, Steven R. Brant, Jean Paul Achkar, Judy H. Cho, Franklin J. Nouvet, Toshihiko Okazaki   +16 more
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Combined immunodeficiency caused by a novel homozygous NFKB1 mutation [PDF]

Journal of Allergy and Clinical Immunology, 2021
Genetic faults in several components of the nuclear factor-κB pathway cause immunodeficiency. Most defects lead to combined immunodeficiency with a range of severity. Heterozygous mutations in NFKB1 were associated with common variable immunodeficiency, however, homozygous mutations have not been described.We studied the molecular basis of combined ...
Daniele Merico, Linda Vong, Brenda Reid, Nigel Sharfe, Chaim M. Roifman, Bo Ngan, Harjit Dadi, Zahra Nagdi, Amarilla B. Mandola   +8 more
openaire   +2 more sources

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Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID

Clinical and Experimental Immunology, 2022
AbstractCommon variable immunodeficiency (CVID) is a ‘late-onset’ primary immunodeficiency characterized by variable manifestations and genetic heterogeneity. A monogenic cause of CVID has been reported in 10% of patients. In this study, we identified two novel pathogenic variants implicated in monogenic CVID by whole exome sequencing (WES) analysis: a
Anli Liu, Qiang Liu, Shaoqiu Leng, Xiaoyu Zhang, Qi Feng, Jun Peng, Gege Feng   +6 more
openaire   +2 more sources

Convergent lines of evidence supporting involvement of NFKB1 in schizophrenia

Psychiatry Research, 2022
NFKB1 was associated with treatment-refractory schizophrenia (SZ) and response to antipsychotics; however, the underlying mechanisms through which NFKB1 confers its risk for SZ are largely unknown. We aimed to investigate the potential role of NFKB1 in SZ.In the present study, we investigated the association of the risk SNP rs230529 of NFKB1 with gray ...
Jing Long, Lin Tian, Ancha Baranova, Hongbao Cao, Yao Yao, Shuquan Rao, Fuquan Zhang   +6 more
openaire   +2 more sources

Assessment of disease activity and management of patients with NFkB1 insufficiency

Clinical Immunology, 2023
Weitere Nicht-UDE Autor:innen wurden nicht mit aufgeführt.
Hassunah, Pia, Grimbacher, Bodo, Authors, Additional   +2 more
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A new avenue for molecular glues: Rapid discovery of a NFKB1 degrader

Cell Chemical Biology, 2023
Targeted protein degradation using molecular glues is a powerful method for targeting traditionally undruggable proteins. One challenge in molecular glue discovery is the absence of rational discovery methods. Here, King et al. leverage covalent library screening with chemoproteomics platforms to rapidly discover a molecular glue targeting NFKB1 via ...
Angela T, Fan, Bridget T, Boyle, Fleur M, Ferguson   +2 more
openaire   +2 more sources

RETRACTED: NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis

Cellular Immunology, 2018
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor and the authors, following concerns raised in the public domain.
Songke Shen, Anping Zhang, Bo Liang, Zhengwei Zhu, Liangdan Sun, Wenjun Wang, Sen Yang, Leilei Wen, Xianbo Zuo, Xianyong Yin, Yujun Sheng, Caihong Zhu, Jinping Gao, Huayang Tang, Xianfa Tang, Xuejun Zhang, Hui Cheng, Lu Liu, Fusheng Zhou, Yinjuan Shi, Chao Yang, Xiaodong Zheng   +21 more
openaire   +3 more sources

NFKB1 Is a Direct Target of the TAL1 Oncoprotein in Human T Leukemia Cells

Cancer Research, 2006
Abstract We recently showed that a subset of human T acute lymphoblastic leukemia (T-ALL) cell lines expresses low basal levels of p50, a nuclear factor-κB (NF-κB)/Rel family member, resulting in their capacity to activate the atypical p65:cRel complex rather than the classic p50:p65 dimer.
Shigeki Miyamoto, Michelle A. Kelliher, Kyle M. Draheim, Pei-Yun Chang   +3 more
openaire   +3 more sources

HIF1 (rs11549465) and NFKB1 (rs28362491) variants association with obesity in Malaysia

Meta Gene, 2020
Abstract Objectives The aim of this study was to do determine the role of variants in HIF1 (rs11549465) and NFKB1 (rs28362491) with obesity in Malay subjects. Methods This case-control study comprises of a total of 188 Malay subjects [93 obese (BMI > 30 kg/m2) and 95 normal (BMI18.5–22.9 kg/m2) as a control group].
Omar Mahmoud Al-Shajrawi, Omar Mahmoud Al-Shajrawi, Einas Basit, Atif Amin Baig   +3 more
openaire   +2 more sources