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Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris
Archives of Dermatological Research, 2008Nuclear factor kappa-beta (NF-kappaB) is a critical transcription factor modulating the expression of many genes involved in the pathogenesis of psoriasis. SUMO4 is a negative regulator of NF-kappaB in the cell-signaling pathway. Two functional polymorphisms of the NFKB1 and SUMO4 genes have been found to be associated with the risks of some autoimmune-
Miao Li +9 more
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Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype
Oncogene, 2017Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell like (ABC). Although ABC-DLBCL has been associated with NF-κB activation, the relationships between activation of specific NF-κB signals and DLBCL phenotype remain ...
Xiangxue Guo +21 more
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A Functional Promoter Polymorphism inNFKB1Increases Susceptibility to Endometriosis
DNA and Cell Biology, 2010Numerous proinflammatory cytokines, such as TNFalpha and IL-6, which are nuclear factor kappaB (NF-kappaB) target genes, have been shown to promote proliferation in endometriotic cells, and several other genes involved in promoting growth are also NF-kappaB target genes. The aim of this study was to investigate whether the functional insertion/deletion
Bin Zhou +7 more
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Dominant NFKB1 Mutations Cause Antibody Deficiency and Autoinflammatory Episodes
Blood, 2015Abstract The NFkB signaling pathway is a master regulator of the immune response. Recently, dominant mutations in NFKB2 have shown to cause antibody deficiency with adrenal insufficiency. We investigated two families with antibody deficiency and autoinflammatory features, with onset in teenage years and early adulthood ...
Christopher L. Fogarty +23 more
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Tissue Antigens, 2005
Abstract: Nuclear factor (NF)‐κB plays an important role in inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A functional insertion/deletion polymorphism (−94ins/delATTG) has been identified in the promoter of the NFKB1 gene.
Orozco, G. +7 more
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Abstract: Nuclear factor (NF)‐κB plays an important role in inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A functional insertion/deletion polymorphism (−94ins/delATTG) has been identified in the promoter of the NFKB1 gene.
Orozco, G. +7 more
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NFKB1 variants were associated with the risk of Parkinson´s disease in male
Journal of Neural TransmissionThe NF-κB pathway is involved in the pathogenesis of neurological disorders that have inflammation as a hallmark, including Parkinson's disease (PD). Our objective was to determine whether common functional variants in the NFKB1, NFKBIA and NFKBIZ genes were associated with the risk of PD.
Sergio, Perez-Oliveira +10 more
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The Expanding Spectrum of NFkB1 Deficiency
Journal of Clinical Immunology, 2016Stuart G. Tangye, Vanessa L. Bryant
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The role of nfkb1 in hemogenic endothelial cell production
ABSTRACT Blood related disorders like acute myelogenous leukemia often rely on allogeneic hematopoietic stem cell transplantations as a form of therapy1. However, graft-versus-host disease (GVHD) is a common result of this therapy, the consequences of which can worsen the patient’s symptoms and in some cases, can become fatal2.openaire +2 more sources