Results 21 to 30 of about 23,374 (217)

Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA. [PDF]

Molecular and Cellular Biology, 1993
The subunits of NF-kappa B, NFKB1 (formerly p50) and RelA (formerly p65), belong to a growing family of transcription factors that share extensive similarity to the c-rel proto-oncogene product. The homology extends over a highly conserved stretch of approximately 300 amino acids termed the Rel homology domain (RHD).
T A, Coleman, C, Kunsch, M, Maher, S M, Ruben, C A, Rosen   +4 more
openaire   +2 more sources

Association of NFKB1 gene rs28362491 mutation with the occurrence of major adverse cardiovascular events

BMC Cardiovascular Disorders, 2022
Background Several studies have reported that NFKB1 gene rs28362491 polymorphism was associated with susceptibility to coronary heart disease in populations of different genetic backgrounds.
Jun-Yi Luo, Fen Liu, Tong Zhang, Ting Tian, Fan Luo, Xiao-Mei Li, Yi-Ning Yang   +6 more
doaj   +1 more source

Circ-NFKB1 sponges miR-203a-5p to regulate ERBB4 expression and promotes IL-1β induced chondrocytes apoptosis

Journal of Orthopaedic Surgery and Research, 2023
Background Osteoarthritis (OA) is a chronic disease of the bones and joints that commonly affects middle-aged and elderly individuals, characterized by the degeneration of articular cartilage and inflammation of the joints. The molecular mechanisms of OA
Zhao Wang, Hongwei Bao, Jingzhao Hou, Bin Ju, Yong Ji   +4 more
doaj   +1 more source

Relación del gen NFKB1 con periodontitis

RECIMUNDO, 2022
En la periodontitis como resultado de la respuesta inmune frente a los microorganismos orales, se produce la destrucción del tejido de soporte dental, lo que eventualmente conduce a la formación de bolsas periodontales, resorción ósea alveolar y pérdida de dientes. No solamente los factores ambientales y genéticos modulan la progresión de la enfermedad
María Eugenia Paredes Herrera, María José Cano Espinoza   +1 more
openaire   +1 more source

Low ABCB1 gene expression is an early event in colorectal carcinogenesis. [PDF]

PLoS ONE, 2013
The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the
Vibeke Andersen, Ulla Vogel, Sine Godiksen, Franz B Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure, Lotte K Vogel   +7 more
doaj   +1 more source

NFKB1: a suppressor of inflammation, ageing and cancer [PDF]

The FEBS Journal, 2016
The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits that form the homo‐ and heterodimeric NF‐κB complexes. Although biochemical and gene knockout studies have demonstrated overlapping and distinct functions for these ...
Tyrell, Cartwright, Neil D, Perkins, Caroline, L Wilson   +2 more
openaire   +2 more sources

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration [PDF]

, 2017
Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of ...
A Iannetti, A Rehemtulla, AB Rogers, B Bang, C Van Themsche, CA Duckworth, CY Wang, DH Phillips, DY Graham, F Liu, J Burclaff, JB Saenz, JG Fox, JM Williams, K Ijiri, M Sigal, M Yu, MD Burkitt, MD Burkitt, MD Burkitt, N Novac, P Correa, R Hu, R Poltz, SMC Przemeck, WJ Huh, X Wang, Y Wang, YJ Merga   +28 more
core   +1 more source

Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features. [PDF]

PLoS ONE, 2013
Constitutive activation of nuclear factor (NF)-κB is frequently observed in hepatocellular carcinoma (HCC). The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the ...
Chao-Wen Cheng, Jen-Liang Su, Chiao-Wen Lin, Chun-Wen Su, Chun-Han Shih, Shun-Fa Yang, Ming-Hsien Chien   +6 more
doaj   +1 more source

Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum [PDF]

Frontiers in Genetics, 2021
Pyoderma gangrenosum (PG) is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Ulcerations associated with PG may occur after trauma or injury to the skin. The etiology has not been clearly elucidated. Our report described a PG patient with a heterozygous splice-donor-
Ran Fang, Jun Wang, Xiao-yun Jiang, Shi-hao Wang, Hao Cheng, Qing Zhou   +5 more
openaire   +3 more sources

Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer. [PDF]

PLoS ONE, 2012
Oral cancer, which is the fourth most common cancer in Taiwanese men, is associated with environmental carcinogens. The possibility that genetic predisposition in nuclear factor-kappa B (NF-κB)-signaling pathways activation is linked to the development ...
Chiao-Wen Lin, Yih-Shou Hsieh, Chung-Han Hsin, Chun-Wen Su, Chien-Huang Lin, Lin-Hung Wei, Shun-Fa Yang, Ming-Hsien Chien   +7 more
doaj   +1 more source