Results 21 to 30 of about 20,241 (230)

NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome [PDF]

Bioscience Reports, 2019
Abstract The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved. NF-κB, a central regulator of inflammation, is involved in various inflammatory diseases. The aim of the present study was to explore the association between NFKB1 gene rs28362491 (-94ATTGins/del) polymorphism and ACS.
Si-Yu Jin, Jun-Yi Luo, Xiao-Mei Li, Fen Liu, Yi-Tong Ma, Xiao-Ming Gao, Yi-Ning Yang   +6 more
openaire   +4 more sources

Analytical screening of polymorphic variants of 20S proteasome genes when planning a study of pathogenetic effects of modification of NFKB1 post-translational processing

Фундаментальная и клиническая медицина, 2023
Aim. Formation of polymorphic variants panel of the proteasome genes 20S, potentially significant for the study as balance modifier factors of p105/p50 NFKB1.Materials and methods.
A. V. Meyer, M. V. Ulyanova, D. O. Imekina, A. D. Padyukova, T. A. Tolochko, E. A. Astafieva, M. B. Lavryashina   +6 more
doaj   +1 more source

Common Variable Immunodeficiency and Neurodevelopmental Delay Due to a 13Mb Deletion on Chromosome 4 Including the NFKB1 Gene: A Case Report

Frontiers in Immunology, 2022
Syndromic immunodeficiencies are a heterogeneous group of inborn errors of immunity that can affect the development of non-immune organs and systems. The genetic basis of these immunodeficiencies is highly diverse, ranging from monogenic defects to large
Clara Franco-Jarava, Clara Franco-Jarava, Clara Franco-Jarava, Irene Valenzuela, Irene Valenzuela, Jacques G. Riviere, Jacques G. Riviere, Jacques G. Riviere, Marina Garcia-Prat, Marina Garcia-Prat, Marina Garcia-Prat, Mónica Martínez-Gallo, Mónica Martínez-Gallo, Mónica Martínez-Gallo, Romina Dieli-Crimi, Romina Dieli-Crimi, Romina Dieli-Crimi, Neus Castells, Neus Castells, Laura Batlle-Masó, Laura Batlle-Masó, Pere Soler-Palacin, Pere Soler-Palacin, Pere Soler-Palacin, Roger Colobran, Roger Colobran, Roger Colobran, Roger Colobran   +27 more
doaj   +1 more source

Contribution of polymorphic variants of the NFKB1 transcription factor gene to the development of multifactorial diseases with an infammatory component

Фундаментальная и клиническая медицина, 2022
NFKB1 — a product of the same-name gene – is a transcription factor that regulates the expression of target genes which encode a wide range of proteins with properties essential for functioning of the body.
A. V. Meyer, T. A. Tolochko, E. A. Astafyeva, M. V. Ulyanova, D. O. Imekina, M. B. Lavryashina   +5 more
doaj   +1 more source

Aplastic anemia in a patient with CVID due to NFKB1 haploinsufficiency [PDF]

Molecular Case Studies, 2020
Acquired aplastic anemia (AA) is a life-threatening bone marrow failure caused by an autoimmune cytotoxic T lymphocyte attack on hematopoietic stem and progenitor cells. Factors contributing to aberrant autoimmune activation in AA include a deficit of T regulatory cells and high levels of inflammatory cytokines.
Daria V. Babushok, Daria V. Babushok, Natasha Stanley, Natasha Stanley, Natasha Stanley, Jane Juusola, Adam Bagg, Stephanie N. Hurwitz, Tammarah Sklarz   +8 more
openaire   +2 more sources

Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells

Frontiers in Immunology, 2021
Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the status of master regulator of the immune response. Much of what we understand of the role of NF-ĸB in immune development, homeostasis and inflammation comes ...
Domenico Somma, Fatma O. Kok, David Kerrigan, Christine A. Wells, Ruaidhrí J. Carmody   +4 more
doaj   +1 more source

A dataset on NFKB1/NFKB2 knockout Jurkat cells and primary CD4+ T cells generated by CRISPR/Cas9 mediated gene disruption. [PDF]

Data Brief
Osada E, Manome Y, Sato Y.
europepmc   +2 more sources

Common variable immunodeficiency in two kindreds with heterogeneous phenotypes caused by novel heterozygous NFKB1 mutations

Frontiers in Immunology, 2022
NFKB1 haploinsufficiengcy was first described in 2015 in three families with common variable immunodeficiency (CVID), presenting heterogeneously with symptoms of increased infectious susceptibility, skin lesions, malignant lymphoproliferation and ...
Frederik Staels, Frederik Staels, Kerstin De Keukeleere, Kerstin De Keukeleere, Matias Kinnunen, Salla Keskitalo, Flaminia Lorenzetti, Flaminia Lorenzetti, Michiel Vanmeert, Teresa Prezzemolo, Emanuela Pasciuto, Emanuela Pasciuto, Eveline Lescrinier, Xavier Bossuyt, Margaux Gerbaux, Mathijs Willemsen, Julika Neumann, Sien Van Loo, Anniek Corveleyn, Karen Willekens, Ingeborg Stalmans, Isabelle Meyts, Isabelle Meyts, Adrian Liston, Adrian Liston, Stephanie Humblet-Baron, Mikko Seppänen, Markku Varjosalo, Rik Schrijvers, Rik Schrijvers   +29 more
doaj   +1 more source

NFKB1: a suppressor of inflammation, ageing and cancer [PDF]

The FEBS Journal, 2016
The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits that form the homo‐ and heterodimeric NF‐κB complexes. Although biochemical and gene knockout studies have demonstrated overlapping and distinct functions for these ...
Tyrell N. Cartwright, Caroline L. Wilson, Neil D. Perkins   +2 more
openaire   +3 more sources

A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer. [PDF]

J Transl Med
Chen Y, Li Q, Wang Z, Sun LV, Hou SX.
europepmc   +2 more sources