Results 31 to 40 of about 21,043 (239)
NFKB1: a suppressor of inflammation, ageing and cancer [PDF]
The FEBS Journal, 2016 The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits that form the homo‐ and heterodimeric NF‐κB complexes. Although biochemical and gene knockout studies have demonstrated overlapping and distinct functions for these ...
Tyrell N. Cartwright +2 more
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Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA. [PDF]
Molecular and Cellular Biology, 1993 The subunits of NF-kappa B, NFKB1 (formerly p50) and RelA (formerly p65), belong to a growing family of transcription factors that share extensive similarity to the c-rel proto-oncogene product. The homology extends over a highly conserved stretch of approximately 300 amino acids termed the Rel homology domain (RHD).
Steven M. Ruben +4 more
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Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum [PDF]
Frontiers in Genetics, 2021 Pyoderma gangrenosum (PG) is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Ulcerations associated with PG may occur after trauma or injury to the skin. The etiology has not been clearly elucidated. Our report described a PG patient with a heterozygous splice-donor-
Xiao-yun Jiang +5 more
openaire +4 more sources
Oncotarget, 2015 Aging is a progressive process that involves a combination of genetic and acquired factors that ultimately cause loss of tissue homeostasis and death. Among the pathways that modulate aging, NF-κ B has been shown to play a central role [1]. Interestingly, the majority of studies examining NF-κB and aging suggest that this transcription factor promotes ...
Bakhtiar Yamini
openalex +4 more sources
Herbal combination from Moringa oleifera Lam. and Curcuma longa L. as SARS-CoV-2 antiviral via dual inhibitor pathway: A viroinformatics approach. [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: The COVID-19 outbreak is caused by the transmission and infection of SARS-CoV-2 at the end of 2019. It has led many countries to implement lockdown policies to prevent the viral spreading.
Viol Dhea Kharisma +10 more
doaj
Frontiers in Immunology, 2023 We report the case of a patient with common variable immunodeficiency (CVID) presenting with short stature and treated with recombinant human growth hormone (rhGH).
S. Ricci +19 more
doaj +1 more source
Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor [PDF]
Oncogene, 2014 NF-κB proteins play a central and subunit-specific role in the response to DNA damage. Previous work identified p50/NF-κB1 as being necessary for cytotoxicity in response to DNA alkylation damage. Given the importance of damage-induced cell death for the maintenance of genomic stability, we examined whether Nfkb1 acts as a tumor suppressor in the ...
Adam M. Schmitt +13 more
openaire +3 more sources
BMC Cardiovascular Disorders, 2022 Background Several studies have reported that NFKB1 gene rs28362491 polymorphism was associated with susceptibility to coronary heart disease in populations of different genetic backgrounds.
Jun-Yi Luo +6 more
doaj +1 more source
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Background Osteoarthritis (OA) is a chronic disease of the bones and joints that commonly affects middle-aged and elderly individuals, characterized by the degeneration of articular cartilage and inflammation of the joints. The molecular mechanisms of OA
Zhao Wang +4 more
doaj +1 more source