Results 31 to 40 of about 23,374 (217)

Vulnerability to Meningococcal Disease in Immunodeficiency Due to a Novel Pathogenic Missense Variant in NFKB1

Frontiers in Immunology, 2021
NF-κB1 deficiency is suggested to be the most common cause of common variable immunodeficiency (CVID). NFKB1 encodes for the p105 precursor protein of NF-κB1, which is converted into the active transcriptional subunit p50 through proteasomal processing ...
Manfred Anim, Manfred Anim, Georgios Sogkas, Georgios Sogkas, Gunnar Schmidt, Natalia Dubrowinskaja, Torsten Witte, Reinhold Ernst Schmidt, Reinhold Ernst Schmidt, Faranaz Atschekzei, Faranaz Atschekzei   +10 more
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

The Extract of Ilex cornuta Bark Promotes Bone Healing by Activating Adenosine A2A Receptor

Drug Design, Development and Therapy, 2022
Xi Zheng,1 Jingyi Wang,1 Junlin Zhou,2 Dong Wang2 1Department of SICU, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 2Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University ...
Zheng X, Wang J, Zhou J, Wang D
doaj  

The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]

, 2019
Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M., Fini, M., Minguzzi, M., Pagani, S., Santi, S., Scotto D'Abusco, A., Sicuro, L., Veronesi, F.   +7 more
core   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis

Clinical Epigenetics, 2023
Background Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type and level of metal exposure and epigenetic changes in subjects exposed to high concentrations of ...
Ani Stepanyan, Anna Petrackova, Siras Hakobyan, Jakub Savara, Suren Davitavyan, Eva Kriegova, Arsen Arakelyan   +6 more
doaj   +1 more source

NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages Through TPL-2-dependent ERK Activation [PDF]

, 2010
available in PMC 2012 February 15.Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear.
Agnes Mambole, Amichay, Anne O’Garra, Bruce H. Horwitz, Ezana Demissie, Huei-Ting Yang, Introna, James G. Fox, Kastenbauer, Michal F. Tomczak, Stamatia Papoutsopoulou, Steven C. Ley, Susan E. Erdman, Xixing Zhao, Yanyan Wang   +14 more
core   +1 more source

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes [PDF]

Journal of Allergy and Clinical Immunology, 2017
The nuclear factor κ light-chain enhancer of activated B cells (NF-κB) signaling pathway is a key regulator of immune responses. Accordingly, mutations in several NF-κB pathway genes cause immunodeficiency.We sought to identify the cause of disease in 3 unrelated Finnish kindreds with variable symptoms of immunodeficiency and autoinflammation.We ...
Meri Kaustio, Emma Haapaniemi, Helka Göös, Timo Hautala, Giljun Park, Jaana Syrjänen, Elisabet Einarsdottir, Biswajyoti Sahu, Sanna Kilpinen, Samuli Rounioja, Christopher L. Fogarty, Virpi Glumoff, Petri Kulmala, Shintaro Katayama, Fitsum Tamene, Luca Trotta, Ekaterina Morgunova, Kaarel Krjutškov, Katariina Nurmi, Kari Eklund, Anssi Lagerstedt, Merja Helminen, Timi Martelius, Satu Mustjoki, Jussi Taipale, Janna Saarela, Juha Kere, Markku Varjosalo, Mikko Seppänen   +28 more
openaire   +3 more sources

Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis.

PLoS Genetics, 2022
Atopic dermatitis (AD) is one of the most common skin disorders among children. Disease etiology involves genetic and environmental factors, with 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin and CD4+ T cell ...
Amy A Eapen, Sreeja Parameswaran, Carmy Forney, Lee E Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David I Bernstein, Ashley L Devonshire, Marc E Rothenberg, Matthew T Weirauch, Leah C Kottyan   +18 more
doaj   +1 more source

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source