Results 41 to 50 of about 20,241 (230)

Low ABCB1 gene expression is an early event in colorectal carcinogenesis. [PDF]

PLoS ONE, 2013
The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the
Vibeke Andersen, Ulla Vogel, Sine Godiksen, Franz B Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure, Lotte K Vogel   +7 more
doaj   +1 more source

Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum [PDF]

Frontiers in Genetics, 2021
Pyoderma gangrenosum (PG) is a rare, destructive inflammatory skin disease of which a painful nodule or pustule breaks down to form a progressively enlarging ulcer. Ulcerations associated with PG may occur after trauma or injury to the skin. The etiology has not been clearly elucidated. Our report described a PG patient with a heterozygous splice-donor-
Xiao-yun Jiang, Hao Cheng, Jun Wang, Shihao Wang, Qing Zhou, Ran Fang   +5 more
openaire   +3 more sources

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration [PDF]

, 2017
Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of ...
A Iannetti, A Rehemtulla, AB Rogers, B Bang, C Van Themsche, CA Duckworth, CY Wang, DH Phillips, DY Graham, F Liu, J Burclaff, JB Saenz, JG Fox, JM Williams, K Ijiri, M Sigal, M Yu, MD Burkitt, MD Burkitt, MD Burkitt, N Novac, P Correa, R Hu, R Poltz, SMC Przemeck, WJ Huh, X Wang, Y Wang, YJ Merga   +28 more
core   +1 more source

Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features. [PDF]

PLoS ONE, 2013
Constitutive activation of nuclear factor (NF)-κB is frequently observed in hepatocellular carcinoma (HCC). The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the ...
Chao-Wen Cheng, Jen-Liang Su, Chiao-Wen Lin, Chun-Wen Su, Chun-Han Shih, Shun-Fa Yang, Ming-Hsien Chien   +6 more
doaj   +1 more source

Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer. [PDF]

PLoS ONE, 2012
Oral cancer, which is the fourth most common cancer in Taiwanese men, is associated with environmental carcinogens. The possibility that genetic predisposition in nuclear factor-kappa B (NF-κB)-signaling pathways activation is linked to the development ...
Chiao-Wen Lin, Yih-Shou Hsieh, Chung-Han Hsin, Chun-Wen Su, Chien-Huang Lin, Lin-Hung Wei, Shun-Fa Yang, Ming-Hsien Chien   +7 more
doaj   +1 more source

Vulnerability to Meningococcal Disease in Immunodeficiency Due to a Novel Pathogenic Missense Variant in NFKB1

Frontiers in Immunology, 2021
NF-κB1 deficiency is suggested to be the most common cause of common variable immunodeficiency (CVID). NFKB1 encodes for the p105 precursor protein of NF-κB1, which is converted into the active transcriptional subunit p50 through proteasomal processing ...
Manfred Anim, Manfred Anim, Georgios Sogkas, Georgios Sogkas, Gunnar Schmidt, Natalia Dubrowinskaja, Torsten Witte, Reinhold Ernst Schmidt, Reinhold Ernst Schmidt, Faranaz Atschekzei, Faranaz Atschekzei   +10 more
doaj   +1 more source

Loss of Nfkb1 leads to early onset aging

Aging, 2014
NF-κB is a major regulator of age-dependent gene expression and the p50/NF-κB1 subunit is an integral modulator of NF-κB signaling. Here, we examined Nfkb1-/- mice to investigate the relationship between this subunit and aging. Although Nfkb1-/- mice appear similar to littermates at six months of age, by 12 months they have a higher incidence of ...
Clayton D. Crawley, Giovanna M. Bernal, Shijun Kang, Bakhtiar Yamini, Hua Liang, Joshua S. Wahlstrom, Peter Pytel, Kirk E. Cahill, Ralph R. Weichselbaum   +8 more
openaire   +3 more sources

The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]

, 2019
Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M., Fini, M., Minguzzi, M., Pagani, S., Santi, S., Scotto D'Abusco, A., Sicuro, L., Veronesi, F.   +7 more
core   +1 more source

Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis

Clinical Epigenetics, 2023
Background Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the type and level of metal exposure and epigenetic changes in subjects exposed to high concentrations of ...
Ani Stepanyan, Anna Petrackova, Siras Hakobyan, Jakub Savara, Suren Davitavyan, Eva Kriegova, Arsen Arakelyan   +6 more
doaj   +1 more source

The Extract of Ilex cornuta Bark Promotes Bone Healing by Activating Adenosine A2A Receptor

Drug Design, Development and Therapy, 2022
Xi Zheng,1 Jingyi Wang,1 Junlin Zhou,2 Dong Wang2 1Department of SICU, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 2Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University ...
Zheng X, Wang J, Zhou J, Wang D
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