Results 51 to 60 of about 20,241 (230)

Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis.

PLoS Genetics, 2022
Atopic dermatitis (AD) is one of the most common skin disorders among children. Disease etiology involves genetic and environmental factors, with 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin and CD4+ T cell ...
Amy A Eapen, Sreeja Parameswaran, Carmy Forney, Lee E Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David I Bernstein, Ashley L Devonshire, Marc E Rothenberg, Matthew T Weirauch, Leah C Kottyan   +18 more
doaj   +1 more source

A Pathogenic Missense Variant in NFKB1 Causes Common Variable Immunodeficiency Due to Detrimental Protein Damage

Frontiers in Immunology, 2021
In common variable immunodeficiency (CVID), heterozygous damaging NFKB1 variants represent the most frequent monogenic cause. NFKB1 encodes the precursor p105, which undergoes proteasomal processing to generate the mature NF-κB transcription factor ...
Manfred Fliegauf, Manfred Fliegauf, Renate Krüger, Sophie Steiner, Leif Gunnar Hanitsch, Sarah Büchel, Volker Wahn, Horst von Bernuth, Horst von Bernuth, Horst von Bernuth, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +13 more
doaj   +1 more source

A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis

International Journal of Immunogenetics, 2005
SummaryNuclear factor κB (NF‐κB) designates a group of critical transcription factors involved in a variety of immunologic and/or inflammatory processes. Conceivably, genes involved in the NF‐κB pathway make interesting candidate genes for chronic inflammatory disorders, including the inflammatory bowel diseases (IBD), Crohn's disease (CD) and ...
Borm, M.E., van Bodegraven, A.A., Mulder, C.J.J., Kraal, G., Bouma, G.   +4 more
openaire   +4 more sources

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? [PDF]

, 2016
Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche.
Johnson, Zariel I., Risbud, Makarand V., Shapiro, Irving M.   +2 more
core   +2 more sources

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes [PDF]

Journal of Allergy and Clinical Immunology, 2017
The nuclear factor κ light-chain enhancer of activated B cells (NF-κB) signaling pathway is a key regulator of immune responses. Accordingly, mutations in several NF-κB pathway genes cause immunodeficiency.We sought to identify the cause of disease in 3 unrelated Finnish kindreds with variable symptoms of immunodeficiency and autoinflammation.We ...
Kari K. Eklund, Jaana Syrjänen, Mikko Seppänen, Jussi Taipale, Petri Kulmala, Petri Kulmala, Timo Hautala, Timi Martelius, Meri Kaustio, Janna Saarela, Giljun Park, Elisabet Einarsdottir, Merja Helminen, Satu Mustjoki, Satu Mustjoki, Virpi Glumoff, Anssi Lagerstedt, Samuli Rounioja, Kaarel Krjutškov, Sanna Kilpinen, Katariina Nurmi, Helka Göös, Shintaro Katayama, Emma Haapaniemi, Fitsum Tamene, Christopher L. Fogarty, Luca Trotta, Biswajyoti Sahu, Juha Kere, Juha Kere, Markku Varjosalo, Ekaterina Morgunova   +31 more
openaire   +4 more sources

NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells. [PDF]

PLoS ONE, 2016
Sepsis, with a persistently high 90-day mortality of about 46%, is the third most frequent cause of death in intensive care units worldwide. Further understanding of the inflammatory signaling pathways occurring in sepsis is important for new efficient ...
Matthias Unterberg, Maxmiliane Julia Kreuzer, Simon Thomas Schäfer, Zainab Bazzi, Michael Adamzik, Katharina Rump   +5 more
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

Genetics and Molecular Research, 2015
Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study
Cai Ps, Liang Hb, Chen Lp
openaire   +3 more sources

Charting the NF-kB pathway interactome map [PDF]

, 2010
One of the phenomena observed in human aging is the progressive increase of a systemic inflammatory state, a condition referred to as “inflammaging”, negatively correlated with longevity. The five components of the Nuclear Factor kB (NF-kB)
Alberto Termanini, Claudio Franceschi, Elena Bellavista, Paolo Tieri, Stefano Salvioli   +4 more
core   +2 more sources

NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages Through TPL-2-dependent ERK Activation [PDF]

, 2010
available in PMC 2012 February 15.Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear.
Agnes Mambole, Amichay, Anne O’Garra, Bruce H. Horwitz, Ezana Demissie, Huei-Ting Yang, Introna, James G. Fox, Kastenbauer, Michal F. Tomczak, Stamatia Papoutsopoulou, Steven C. Ley, Susan E. Erdman, Xixing Zhao, Yanyan Wang   +14 more
core   +1 more source