Results 51 to 60 of about 23,374 (217)

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens [PDF]

, 2018
Genetic screens help infer gene function in mammalian cells, but it has remained difficult to assay complex phenotypes—such as transcriptional profiles—at scale.
Adamson, Britt, Burks, Tyler, Chen, Jenny, Dionne, Danielle, Dixit, Atray, Friedman, Nir, Fulco, Charles P., Jerby-Arnon, Livnat, Lander, Eric Steven, Li, Biyu, Marjanovic, Nemanja D., Norman, Thomas M., Parnas, Oren, Raychowdhury, Raktima, Regev, Aviv, Weissman, Jonathan S.   +15 more
core   +1 more source

Defective Function of Inhibitor of κB Kinase Subunit Beta Associated With Multiple Immune-Mediated Disorders. [PDF]

Exp Dermatol
ABSTRACT Abnormal NF‐κB activity has been previously implicated in a range of immune‐mediated disorders. Here, we aimed to elucidate the genetic basis underlying the co‐occurrence of vitiligo, Addison's disease and granuloma annulare in a 43‐year‐old woman.
Malovitski K, Rosenthal NK, Khair L, Hagin D, Freund T, Sharoni E, Peled A, Feller Y, Ishtewy R, Mohamad J, Sarig O, Samuelov L, Sprecher E, Pavlovsky M.   +13 more
europepmc   +2 more sources

MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis

Scientific Reports, 2021
Toll-like receptor (TLR) family signature has been implicated in sepsis etiopathology. We aimed to evaluate the genetic profile of TLR pathway-related key genes; the myeloid differentiation protein 88 (MYD88), IL1 receptor-associated kinase 1 (IRAK1 ...
Nouran B. AbdAllah, Eman A. Toraih, Essam Al Ageeli, Hala Elhagrasy, Nawal S. Gouda, Manal S. Fawzy, Ghada M. Helal   +6 more
doaj   +1 more source

A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study

Cancer Medicine, 2018
Genetic variations of NF‐κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cancer ...
Fa Chen, Fengqiong Liu, Lingjun Yan, Lisong Lin, Yu Qiu, Jing Wang, Junfeng Wu, Xiaodan Bao, Zhijian Hu, Lin Cai, Baochang He   +10 more
doaj   +1 more source

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells [PDF]

, 2002
Transcription factors NF-KB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells.
Baltimore, David, Gerondakis, Steve, Grumont, Raelene J., Gugasyan, Raffi, Metcalf, Donald, Pohl, Thomas, Sha, William, Strasser, Andreas, Tarlinton, David   +8 more
core  

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems [PDF]

, 2012
Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria and the insulin signaling ...
, , Bonàs-Guarch, Sílvia, Draghici, Sorin, Dupuis, Josée, Florez, Jose C., Mercader, Josep M., Mora, Sílvia, Planet, Evarist, Puiggros, Montserrat, Ribas, Vicent, Rodriguez-Cuenca, Sergio, Sebastian, David, Segrè, Ayellet V., Sorianello, Eleonora, Torrents, David, Vidal-Puig, Antoni, Yang, Chenjing, Zorzano, Antonio   +18 more
core   +3 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways [PDF]

, 2015
The molecular basis of cancer and cancer multiple phenotypes are not yet fully understood. Next Generation Sequencing promises new insight into the role of genetic interactions in shaping the complexity of cancer.
Ahuja, Al-Halabi, Albrethsen, Andersen, Bodmer, Brosens, Cerami, Challis, Chen, Chen, Chou, Courtois, Djavaheri-Mergny, Doncheva, Emmert-Streib, Fan, Fearson, Gallois-Montbrun, Glaab, Glusman, González-Pérez, Hendon, Hoesel, Hudson, Huhn, Ignatenko, Jiao, Jones, Karin, Kemp, Kim, Kim, Koduru, Kolde, Kolligs, Kreeger, Li, Li, Lim, Luisi, López de Silanes, MacDonald, Maere, March, Masri, McKenna, Moorchung, Muramatsu, Niimura, O’Bryan, Paz, R Core Team, Rayet, Robbiani, Roberts, Rosenfeld, Shannon, Shi, Shultz, Tang, The Cancer Genome Atlas Network, van Engeland, VanBuren, Venables, Wallmen, Wang, Wang, Warde-Farley, Winkler, Wu, Yahia, Yang, Yiakouvaki, Young, Yu, Zhang, Zhou   +76 more
core   +2 more sources

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)

Autoimmunity, 2022
Childhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early comorbidities.
Denise de Queiroga Nascimento, Isaura Isabelle Fonseca Gomes da Silva, Camilla Albertina Dantas Lima, André de Souza Cavalcanti, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella, Luciana Martins de Carvalho, Paula Sandrin-Garcia   +9 more
doaj   +1 more source