Results 71 to 80 of about 23,374 (217)

Genetic Analyses of NFKB1 and OCA-B Function: Defects in B Cells, Serum IgM Level, and Antibody Responses in Nfkb1−/−Oca-b−/− Mice [PDF]

The Journal of Immunology, 2000
Abstract Defined patterns of gene expression during cell differentiation are likely to be ensured by multiple factors playing redundant roles. By generating mice deficient in both NFKB1 and OCA-B, we show here that the two transcription factors are required for B-1 cell differentiation and serum IgM production.
U, Kim, C S, Gunther, R G, Roeder
openaire   +2 more sources

The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson’s disease

Journal of Neuroinflammation
Background Overactivated microglia are a key contributor to Parkinson’s disease (PD) by inducing neuroinflammation. CD200R1, a membrane glycoprotein mainly found on microglia, is crucial for maintaining quiescence with its dysregulation linked to ...
Suzhen Lin, Yimei Shu, Ruinan Shen, Yifan Zhou, Hong Pan, Lu He, Fang Fang, Xue Zhu, Xinrui Wang, Ying Wang, Wei Xu, Jianqing Ding   +11 more
doaj   +1 more source

IKK-induced NF-kappa B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen [PDF]

, 2014
The importance of IκB kinase (IKK)–induced proteolysis of NF-κB1 p105 in B cells was investigated using Nfkb1SSAA/SSAA mice, in which this NF-κB signaling pathway is blocked.
Alexander Visekruna, Basso, Beinke, Beinke, Buggins, Cyster, Damdinsuren, David M. Tarlinton, De Silva, Derudder, Dumitru, Edina Schweighoffer, Emilie Jacque, Gatto, Gavin, Gerondakis, Gerondakis, Ghosh, Glynne, Goodnow, Goodnow, Grossmann, Grumont, Grumont, Grumont, Grumont, Hettmann, Huntington, Ishikawa, Julia Janzen, Kabouridis, Kaileh, Kallies, Karin, Kelly, Kitamura, Klein, Krappmann, Kravtsova-Ivantsiv, Köntgen, Lang, Li, Mackay, Mason, Mombaerts, Moorthy, Morgan, Ochiai, Oracki, Pasparakis, Peperzak, Pereira, Pereira, Pillai, Pohl, Rachel Zillwood, Reif, Rickert, Robinson, Saito, Salmerón, Savinova, Sciammas, Sha, Shaffer, Solan, Sriskantharajah, Stamatia Papoutsopoulou, Steven C. Ley, Takahashi, Tanigaki, Turner, Victor L.J. Tybulewicz, Waterfield, Yang, Yuseff, Zhang   +76 more
core   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

miRNAs and NFKB1 and TRAF6 target genes: The initial functional study in CD14+ monocytes in rheumatoid arthritis patients [PDF]

Genetics and Molecular Biology
We predicted miRNAs with regulatory impact on NFKB1 and TRAF6 gene expression and selected the miR-194-5p, miR-124-3p, miR-9-5p, and miR-340-5p and their target genes for expression analyses on CD14+ monocytes from rheumatoid arthritis (RA) patients and ...
Isaura Isabelle Fonseca Gomes da Silva, Denise de Queiroga Nascimento, Alexandre Domingues Barbosa, Fabricio Oliveira Souto, Maria de Mascena Diniz Maia, Sergio Crovella, Paulo Roberto Eleuterio de Souza, Paula Sandrin-Garcia   +7 more
doaj   +1 more source

Genome-wide screening of mouse knockouts reveals novel genes required for normal integumentary and oculocutaneous structure and function. [PDF]

, 2019
Oculocutaneous syndromes are often due to mutations in single genes. In some cases, mouse models for these diseases exist in spontaneously occurring mutations, or in mice resulting from forward mutatagenesis screens.
Adissu, Hibret, Berberovic, Zorana, Clary, Dave, Eskandarian, Mohammad, Flenniken, Ann M, International Mouse Phenotyping Consortium, Lloyd, KC Kent, McKerlie, Colin, Moore, Bret A, Moshiri, Ala, Moshiri, Ata S, Murphy, Christopher J, Newbigging, Susan, Nutter, Lauryl MJ, Owen, Celeste, Thomasy, Sara M   +15 more
core  

Macrophage‐Targeted Magnesium Ion‐Nourisher for NLRP3 Inflammasome Inhibition to Enhance Liver Inflammatory Disease Treatment

Advanced Science, EarlyView.
This report describes a nano magnesium nourisher, named MgC@PS, capable of targeted Mg2⁺ delivery to macrophages, effectively suppressing The nuclear factor kappa B (NF‐κB) activation and mitigating NLRP3 inflammasome‐driven pyroptosis in liver inflammation.
Li Wang, Zhuo Yan, Sindhu Yalavarthi, Yusif Abdul‐Rashid, Kiki Parker, Kyle Nowlin, Ethan Li, Jordan Mack, Josephine Wei, Hunter Vu, Zhenquan Jia, Jianjun Wei, Jilong Wang, Kerui Wu   +13 more
wiley   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

A dual covariant biomarker approach to Kawasaki disease, using vascular endothelial growth factor A and B gene expression; implications for coronary pathogenesis

Informatics in Medicine Unlocked, 2023
Introduction: Kawasaki disease (KD) is the most common vasculitis in young children, with coronary artery lesions (CALs) and coronary aneurysms (CAAs) being responsible for most KD-related deaths.
Asrar Rashid, Govind Benakatti, Feras Al-Obeidat, Rajesh Phatak, Zainab A. Malik, Javed Sharief, Raziya Kadwa, Wael Hafez, Mohammed Toufiq, Damien Chaussabel, Rayaz Malik, Nasir Quraishi, Syed Ahmed Zaki, Guftar Shaikh, Amir Hussain   +14 more
doaj   +1 more source

Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures. [PDF]

, 2016
BACKGROUND: HIV-1 entry is a receptor-mediated process directed by the interaction of the viral envelope with the host cell CD4 molecule and one of two co-receptors, CCR5 or CXCR4.
Aiamkitsumrit, Benjamas, Antell, Gregory C, Dampier, Will, Hershberg, Uri, Jacobson, Jeffrey M, Kercher, Katherine, Krebs, Fred C, Nonnemacher, Michael R, Passic, Shendra, Pirrone, Vanessa, Schwartz, Gregory, Wigdahl, Brian, Williams, Jean W, Zhong, Wen   +13 more
core   +2 more sources