Results 81 to 90 of about 20,241 (230)

Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. [PDF]

, 2011
Gene regulatory networks inferred from RNA abundance data have generated significant interest, but despite this, gene network approaches are used infrequently and often require input from bioinformaticians.
Affara, Muna, Araki, Hiromitsu, Charnock-Jones, D Stephen, Cho, Vicky, Crampin, Edmund J, Dunmore, Ben, Humphreys, Sally, Hurley, Daniel, Imoto, Seiya, Kuhara, Satoru, Miyano, Satoru, Print, Cristin G, Sanders, Deborah, Savoie, Christopher, Smith, Stephen, Tamada, Yoshinori, Tashiro, Kosuke, Tomiyasu, Yuki, Yasuda, Kaori   +18 more
core   +2 more sources

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

Insertion/deletion polymorphism in promoter of NFKB1 influences

, 2009
Objective: This study investigated whether the insertionpolymorphism in the promoter of NFĸB1 is associated with the risk of bleeding after tonsillectomy. As Adamzik and coworkers could recently show, the nuclear factor ĸB which plays a critical role in host defense and in chronic inflammatory[for full text, please go to the a.m. URL]
Arweiler-Harbeck, D, Öztürk, E, Bankfalvi, A, Riemann, K, Schmid, KW, Siffert, J, Lang, S, Peters, J, Adamzik, M   +8 more
openaire   +2 more sources

New Synthetic Endocannabinoid as Anti-Inflammaging Cosmetic Active: an In Vitro Study on a Reconstructed Skin Model [PDF]

, 2019
Endocannabinoids have been recently appointed as interesting cosmetic actives in regulating inflammaging, a state of chronic low-grade inflammation, known for being involved in many senescence\u2019s manifestations, included skin aging.
Caviola, E, Galizia, G and Baratto G, Meloni, M, Semenzato, A   +3 more
core  

The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-κB-Dependent c-myc Expression [PDF]

, 2004
Cell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-κB1 and c-Rel transcription factors.
Gerondakis, Steve, Grumont, Raelene, Lock, Peter, Mollinari, Michael, Moore, Anna, Shannon, Frances M   +5 more
core   +1 more source

Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population. [PDF]

PLoS ONE, 2015
Coronary artery disease (CAD) is the most common chronic inflammatory disease worldwide. NF-κB, a central regulator of inflammation, is involved in various inflammatory diseases.
Hong-Mei Lai, Xiao-Mei Li, Yi-Ning Yang, Yi-Tong Ma, Rui Xu, Shuo Pan, Hui Zhai, Fen Liu, Bang-Dang Chen, Qian Zhao   +9 more
doaj   +1 more source

TNF signature in advanced melanoma patients treated with immune checkpoint inhibitors: Results from the MELANFα clinical study

International Journal of Cancer, EarlyView.
What's New? Tumor necrosis factor (TNF) can promote tumor resistance to immune checkpoint inhibitors (ICIs), which are now the standard treatment for advanced melanoma patients. Here, in an advanced melanoma patient cohort, TNF was investigated for a possible predictive relationship with ICI response. Assessments show that after 12 weeks of ICI therapy,
Mathieu Virazels, Amélie Lusque, Stéphanie Brayer, Matthieu Genais, Carine Dufau, Jean Milhès, Thomas Filleron, Cécile Pagès, Vincent Sibaud, Laurent Mortier, Olivier Dereure, Maha Ayyoub, Amandine Fabre, Nathalie Andrieu‐Abadie, Vera Pancaldi, Céline Colacios, Nicolas Meyer, Bruno Ségui, Anne Montfort   +18 more
wiley   +1 more source

Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts. [PDF]

PLoS ONE, 2013
The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads
Jakob Gerhard Stegger, Erik Berg Schmidt, Tina Landsvig Berentzen, Anne Tjønneland, Ulla Vogel, Eric Rimm, Thorkild I A Sørensen, Kim Overvad, Majken K Jensen   +8 more
doaj   +1 more source

Landscape of stimulation-responsive chromatin across diverse human immune cells. [PDF]

, 2019
A hallmark of the immune system is the interplay among specialized cell types transitioning between resting and stimulated states. The gene regulatory landscape of this dynamic system has not been fully characterized in human cells.
Anderson, Mark S, Blaeschke, Franziska, Burt, Trevor D, Calderon, Diego, Criswell, Lindsey A, Gao, Ziyue, Greenleaf, William J, Kathiria, Arwa, Knowles, David A, Lescano, Ninnia, Marson, Alexander, Mezger, Anja, Müller, Fabian, Nguyen, Michelle LT, Nguyen, Vinh, Parent, Audrey V, Pritchard, Jonathan K, Ribado, Jessica V, Trombetta, John, Wu, Beijing   +19 more
core  

Listeria monocytogenes membrane vesicles disrupting intestinal epithelial barrier function via modulating macrophage inflammatory responses

Interdisciplinary Medicine, EarlyView.
Abstract Bacterial extracellular vesicles (BEVs) are actively secreted nanostructures that play a unique role in the pathogenesis of bacterial infections. In this study, we established an intestinal epithelial cell (IEC)/macrophage coculture system and found that Listeria monocytogenes (LM) membrane vesicles (MVs) acted on macrophages and caused ...
Yao Lei, Kehan Chen, Mingyuan Tang, Qiuyang Zhang, Jie Yu, Yunwen Zhang, Tian Tang, Chuan Wang   +7 more
wiley   +1 more source