Results 81 to 90 of about 23,374 (217)

Insertion/deletion polymorphism in promoter of NFKB1 influences

, 2009
Objective: This study investigated whether the insertionpolymorphism in the promoter of NFĸB1 is associated with the risk of bleeding after tonsillectomy. As Adamzik and coworkers could recently show, the nuclear factor ĸB which plays a critical role in host defense and in chronic inflammatory[for full text, please go to the a.m. URL]
Arweiler-Harbeck, D, Öztürk, E, Bankfalvi, A, Riemann, K, Schmid, KW, Siffert, J, Lang, S, Peters, J, Adamzik, M   +8 more
openaire   +2 more sources

Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50

Frontiers in Immunology, 2022
Most of the currently known heterozygous pathogenic NFKB1 (Nuclear factor kappa B subunit 1) variants comprise deleterious defects such as severe truncations, internal deletions, and frameshift variants. Collectively, these represent the most frequent monogenic cause of common variable immunodeficiency (CVID) identified so far.
Manfred Fliegauf, Manfred Fliegauf, Matias Kinnunen, Sara Posadas-Cantera, Nadezhda Camacho-Ordonez, Nadezhda Camacho-Ordonez, Hassan Abolhassani, Hassan Abolhassani, Laia Alsina, Laia Alsina, Faranaz Atschekzei, Faranaz Atschekzei, Delfien J. Bogaert, Delfien J. Bogaert, Siobhan O. Burns, Siobhan O. Burns, Joseph A. Church, Gregor Dückers, Alexandra F. Freeman, Lennart Hammarström, Leif Gunnar Hanitsch, Tessa Kerre, Robin Kobbe, Svetlana O. Sharapova, Kathrin Siepermann, Carsten Speckmann, Carsten Speckmann, Sophie Steiner, Nisha Verma, Jolan E. Walter, Jolan E. Walter, Jolan E. Walter, Emma Westermann-Clark, Emma Westermann-Clark, Sigune Goldacker, Sigune Goldacker, Klaus Warnatz, Klaus Warnatz, Markku Varjosalo, Markku Varjosalo, Markku Varjosalo, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +44 more
openaire   +8 more sources

Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome: a follow up study in three independent cohorts. [PDF]

PLoS ONE, 2013
The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads
Jakob Gerhard Stegger, Erik Berg Schmidt, Tina Landsvig Berentzen, Anne Tjønneland, Ulla Vogel, Eric Rimm, Thorkild I A Sørensen, Kim Overvad, Majken K Jensen   +8 more
doaj   +1 more source

New Synthetic Endocannabinoid as Anti-Inflammaging Cosmetic Active: an In Vitro Study on a Reconstructed Skin Model [PDF]

, 2019
Endocannabinoids have been recently appointed as interesting cosmetic actives in regulating inflammaging, a state of chronic low-grade inflammation, known for being involved in many senescence\u2019s manifestations, included skin aging.
Caviola, E, Galizia, G and Baratto G, Meloni, M, Semenzato, A   +3 more
core  

Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]

, 2018
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M., Gilk, Stacey D., Justis, Anna V., Mulye, Minal, Nallandhighal, Srinivas, Tran, Tuan M.   +5 more
core   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, EarlyView.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis

International Journal of Immunogenetics, 2005
SummaryNuclear factor κB (NF‐κB) designates a group of critical transcription factors involved in a variety of immunologic and/or inflammatory processes. Conceivably, genes involved in the NF‐κB pathway make interesting candidate genes for chronic inflammatory disorders, including the inflammatory bowel diseases (IBD), Crohn's disease (CD) and ...
Borm, M.E., van Bodegraven, A.A., Mulder, C.J.J., Kraal, G., Bouma, G.   +4 more
openaire   +3 more sources

Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population. [PDF]

PLoS ONE, 2015
Coronary artery disease (CAD) is the most common chronic inflammatory disease worldwide. NF-κB, a central regulator of inflammation, is involved in various inflammatory diseases.
Hong-Mei Lai, Xiao-Mei Li, Yi-Ning Yang, Yi-Tong Ma, Rui Xu, Shuo Pan, Hui Zhai, Fen Liu, Bang-Dang Chen, Qian Zhao   +9 more
doaj   +1 more source

Interactions between meat intake and genetic variation in relation to colorectal cancer [PDF]

, 2014
Supplementary material 1 (DOCX 46 ...
Andersen, Vibeke, Vogel, Ulla
core   +3 more sources

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source