Results 91 to 100 of about 37,410 (228)

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

European Journal of Inflammation, 2009
IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source of IL-32, which has been found to be a powerful pro-inflammatory mediator ...
M.L. Castellani, E. Toniato, P. Felaco, C. Ciampoli, D. De Amicis, C. Orso, C. Cucurullo, J. Vecchiet, S. Tetè, V. Salini, A. Caraffa, F. Pandolfi, P.L. Antinolfi, G. Cerulli, F. Conti, M. Fulcheri, G. Sabatino, P. Boscolo, Y.B. Shaik   +18 more
doaj   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Dietary fiber‐based oral nanovaccine promotes gut‐to‐nose trafficking of regulatory cells and drives antigen‐specific tolerance to relieve airway allergy

iMeta, EarlyView.
Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen‐specific immune tolerance. Here, we developed an oral nano‐dietary fiber (NDF) platform that integrates allergen delivery with microbiota‐driven immunomodulation, using dextran as both an antigen carrier and a fermentable substrate for ...
Yuting Qin, Zeming Wang, Yuru Zong, Zefang Lu, Junxiu Liu, Ruifang Zhao, Guangjun Nie, Hanqing Chen   +7 more
wiley   +1 more source

Correlation of urinary histamine concentration with mast cell density in patients with non-muscle invasive urothelial bladder carcinoma [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. There are no reliable tumor markers for non-invasive detection of bladder cancer and monitoring patients after treatment. The role of mast cells in oncogenesis is still unknown. Methods.
Popov Mladen, Lakić Tanja, Miljković Dejan, Isakov Ivana, Levakov Ivan, Bogdanović Jovo, Jeremić Dimitrije, Đozić Senjin, Stojanović Stevan, Vojinov Saša   +9 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Genomic trends and emerging antimicrobial resistance in Neisseria gonorrhoeae over two decades in Kenya

Microbiology Spectrum
We investigated the trends and antimicrobial resistance (AMR) of Neisseria gonorrhoeae (NG) in Kenya with whole-genome sequencing (WGS) of isolates collected in 2002–2009 (n = 108) and 2020–2022 (n = 110).
Supriya D. Mehta, Robyn Thorington, Walter Agingu, Fredrick Otieno, Anastasia Unitt, Laura K. Rusie, Adriana Le Van, Irene Martin, Ann E. Jerse, Odile Harrison   +9 more
doaj   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Additional file 1: Table S1. of Molecular epidemiology of Neisseria gonorrhoeae strains circulating in Indonesia using multi-locus variable number tandem repeat analysis (MLVA) and Neisseria gonorrhoeae multi-antigen sequence typing (NG-MAST) techniques

, 2018
Characteristics and Distribution of Neisseria gonorrhoeae in Minimum Spanning Tree Constructed Based on Multiple-Locus Variable Number Tandem Repeat Analysis (MLVA) Profile of Strains Collected from Indonesian Major Cities in 2014 (DOCX 25 kb)
Hananta, I Putu Yuda, van Dam, Alje, Schim van der Loeff, Maarten, Dierdorp, Mirjam, Wind, Carolien, Soebono, Hardyanto, de Vries, Henry, Bruisten, Sylvia   +7 more
openaire   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source