Results 21 to 30 of about 14,344 (146)

Serum neutrophil gelatinase-associated lipocalin for predicting anemia of inflammation in children with urinary tract infection

Central European Journal of Immunology, 2021
Anemia of inflammation (IA), the second most common cause of childhood anemia, results from macrophage iron sequestration and impaired erythropoiesis. Neutrophil gelatinase-associated lipocalin (NGAL) plays an important role in innate microbial immunity ...
Grazyna Jadwiga Krzemien, Malgorzata Pańczyk-Tomaszewska, Agnieszka Turczyn, Urszula Demkow, Iwona Kotuła, Agnieszka Szmigielska   +5 more
doaj   +1 more source

Urine/Plasma Neutrophil Gelatinase Associated Lipocalin Ratio Is a Sensitive and Specific Marker of Subclinical Acute Kidney Injury in Mice. [PDF]

PLoS ONE, 2016
BACKGROUND:Detection of acute kidney injury (AKI) is still a challenge if conventional markers of kidney function are within reference range. We studied the sensitivity and specificity of NGAL as an AKI marker at different degrees of renal ischemia ...
Tamás Kaucsár, Mária Godó, Csaba Révész, Miklós Kovács, Attila Mócsai, Norbert Kiss, Mihály Albert, Tibor Krenács, Gábor Szénási, Péter Hamar   +9 more
doaj   +1 more source

The origin of plasma neutrophil gelatinase-associated lipocalin in cardiac surgery

BMC Nephrology, 2019
Background Acute kidney injury (AKI) is common after heart surgery. Neutrophil gelatinase-associated lipocalin (NGAL) is produced in injured kidney. NGAL has been used as an early plasma biomarker for AKI in patients undergoing heart surgery. Neutrophils
Arie Passov, Liisa Petäjä, Marjut Pihlajoki, Ulla-Stina Salminen, Raili Suojaranta, Antti Vento, Sture Andersson, Ville Pettilä, Alexey Schramko, Eero Pesonen   +9 more
doaj   +1 more source

Renal neutrophil gelatinase associated lipocalin expression in lipopolysaccharide-induced acute kidney injury in the rat

BMC Nephrology, 2012
Background Neutrophil gelatinase associated lipocalin (NGAL) is a highly predictive biomarker of acute kidney injury. To understand the role of NGAL in renal injury during sepsis, we investigated the temporal changes and biological sources of NGAL in a ...
Han Mei, Li Ying, Liu Maodong, Li Yingmin, Cong Bin   +4 more
doaj   +1 more source

Complex Assessment of the Functional State of the Urinary System in Preclinical Studies. Part 2. Markers of Nephrotoxicity (Review)

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The determination of nephrotoxicity markers is a useful and necessary step in the detection of renal injury in animal experiments; these markers help accurately localise organ damage.
M. V. Miroshnikov, K. T. Sultanova, M. N. Makarova, N. M. Faustova, S. O. Khan, E. A. Loseva   +5 more
doaj   +1 more source

УРОВЕНЬ ЛИПОКАЛИНА В КРОВИ И МОЧЕ У БОЛЬНЫХ ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ В ЗАВИСИМОСТИ ОТ СТРАТЕГИИ РЕВАСКУЛЯРИЗАЦИИ

Архивъ внутренней медицины, 2014
S-NGAL and u-NGAL content was examined for 113 acute coronary syndrome (ACS) patients, depending on revascularization strategy. 39 (66,1%) ACS patients had transcutaneous coronary treatment (TCT), 41 myocardial infarction (MI) patients with ST segment ...
М. А. Шаленкова, З. Д. Михайлова, П. Ф. Климкин   +2 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

Insulin treatment prevents wounding associated changes in tissue and circulating neutrophil MMP-9 and NGAL in diabetic rats.

PLoS ONE, 2017
Neutrophils are important for wound repair, but their persistence can impair the healing process. Neutrophils express matrix metalloproteinases including MMP-9 and its regulator neutrophil gelatinase associated lipocalin (NGAL).
Maryam Abdollahi, Taria Shin Yi Ng, Alireza Rezaeizadeh, Sarah Aamidor, Stephen M Twigg, Danqing Min, Susan V McLennan   +6 more
doaj   +1 more source

Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer.

PLoS ONE, 2012
In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis.
Antonia Sophie Wenners, Keyur Mehta, Sibylle Loibl, Hyerim Park, Berit Mueller, Norbert Arnold, Sigrid Hamann, Joerg Weimer, Beyhan Ataseven, Silvia Darb-Esfahani, Christian Schem, Christoph Mundhenke, Fariba Khandan, Christoph Thomssen, Walter Jonat, Hans-Juergen Holzhausen, Gunther von Minckwitz, Carsten Denkert, Maret Bauer   +18 more
doaj   +1 more source