Results 61 to 70 of about 14,344 (146)

The Role of Fibrinogen in Mediating NGAL-Associated Neuronal Damage in Acute Ischemic Stroke: A Moderated Mediation Analysis

Journal of Inflammation Research
Nan Zhao,1,* Yi Chen,1,* Zhongjiao Lu,1,* Lu Han,1 Yaying Song,1 Jie Ding,1 Desheng Zhu,1 Yangtai Guan1,2 1Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People’s Republic of ...
Zhao N, Chen Y, Lu Z, Han L, Song Y, Ding J, Zhu D, Guan Y   +7 more
doaj  

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review

Kidney & Blood Pressure Research, 2014
NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation.
Katerina Helanova, Jindrich Spinar, Jiri Parenica   +2 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Inhibition of SGLT2 reduces blood pressure in the early phase of salt‐sensitive hypertension in male Dahl‐SS rats independently of changes in renal inflammation

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract Salt‐sensitive hypertension is a progressive condition characterized by albuminuria, renal injury, and inflammation. The initiating mechanisms remain unclear. We hypothesized that early in salt‐sensitive hypertension, the proximal tubule is exposed to excess albumin, thereby triggering cytokine release and renal inflammation.
Rawan N. Almutlaq, Yotesawee Srisomboon, Sridhatri Guntipally, Andrew N. Hakeem, Amanda C. Veiga, Jaryd Ross, Babatunde S. Anidu, Alex Dayton, Scott M. O'Grady, Louise C. Evans   +9 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

Acute Kidney Injury Prediction Model Using Cystatin-C, Beta-2 Microglobulin, and Neutrophil Gelatinase-Associated Lipocalin Biomarker in Sepsis Patients

International Journal of Nephrology and Renovascular Disease
Hani Susianti,1 Aswoco Andyk Asmoro,2 Sujarwoto,3 Wiwi Jaya,2 Heri Sutanto,4 Amanda Yuanita Kusdijanto,1 Kevin Putro Kuwoyo,1 Kristian Hananto,5 Matthew Brian Khrisna1 1Clinical Pathology Department, Faculty of Medicine Brawijaya University/Saiful Anwar ...
Susianti H, Asmoro AA, Sujarwoto, Jaya W, Sutanto H, Kusdijanto AY, Kuwoyo KP, Hananto K, Khrisna MB   +8 more
doaj  

Biomarkers: Acute kidney injury

Journal of Pediatric Critical Care, 2018
Biomarkers can be measured objectively and can assess physiological as well as pathological process or pharmacological response or helps in deciding therapeutic intervention or prognostication of disease.
Kundan Mittal, H K Aggarwal, Anupama Mittal   +2 more
doaj   +1 more source

Study on the mechanism of action of NGAL in renal anemia on iron metabolism and erythrocyte maturation

Linchuang shenzangbing zazhi, 2019
Objective To explore the potential mechanism and main influencing factors of neutrophil gelatinase-associated lipocalin(NGAL) in iron metabolism and erythrocyte maturation of renal anemia, and finding new therapeutic targets for renal anemia.
WU Xin-hong, ZHANG Yun
doaj  

Endothelial function/damage markers and NGAL – intraoperative assessment in blood specimens obtained from different sampling sites during open repair of abdominal aortic aneurysm

Annales Academiae Medicae Silesiensis
Introduction: The aim of the study was to investigate the dynamics of changes in the concentrations of neutrophil gelatinase-associated lipocalin (NGAL), an acute kidney injury biomarker, as well as endothelial function/damage markers including P ...
Michał Kokot, Grzegorz Biolik, Anna Kokot, Leszek Kędzierski, Tadeusz Fojt, Damian Ziaja, Krzysztof Ziaja, Jan Duława   +7 more
doaj   +1 more source