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Human Gene Therapy, 2020 Nerve growth factor (NGF) gene therapy rescues and stimulates cholinergic neurons, which degenerate in Alzheimer's disease (AD). In a recent clinical trial for AD, intraparenchymal adeno-associated virus serotype 2 (AAV2)-NGF delivery was safe but did ...
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Handbook of Experimental Pharmacology, 2014
The discovery of nerve growth factor (NGF) was a seminal event in history of research in developmental neurobiology. The further discovery that NGF was just one of a family of structurally similar growth factors, neurotrophins, provided important insights into the way nerve cells communicate, during development of the nervous system, and in ...
M. Bothwell
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The discovery of nerve growth factor (NGF) was a seminal event in history of research in developmental neurobiology. The further discovery that NGF was just one of a family of structurally similar growth factors, neurotrophins, provided important insights into the way nerve cells communicate, during development of the nervous system, and in ...
M. Bothwell
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NGF/TrkA Signaling as a Therapeutic Target for Pain
Pain Practice, 2016Munetaka Hirose
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The Emerging Therapeutic Role of NGF in Alzheimer’s Disease
Neurochemical Research, 2016Chao-Jin Xu, Wei-Lin Jin
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ATP–NGF-complex, but not NGF, is the neuroprotective ligand
Neurochemistry International, 2011We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS). We have also demonstrated before that NGF and other growth factors form stable non-covalent complexes with ATP.
Katja Bettina, Ferenz +3 more
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One at a time, live tracking of NGF axonal transport using quantum dots
Proceedings of the National Academy of Sciences of the United States of America, 2007 Bianxiao Cui +2 more
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Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
Science, 1990The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and ...
P. Maisonpierre +6 more
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NGF and BDNF in pediatrics syndromes
Neuroscience & Biobehavioral Reviews, 2023Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play multiple roles in different settings including neuronal development, function and survival in both the peripheral and the central nervous systems from early stages.
Ferraguti, Giampiero +9 more
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Experimental Neurology, 1989
Nerve growth factor (NGF) is a well-documented target-derived trophic factor in the peripheral nervous system. Recently, proteins as well as mRNAs for both NGF and its receptor (NGF-R) have been detected in diverse areas in the central nervous system (CNS).
B, Lu +3 more
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Nerve growth factor (NGF) is a well-documented target-derived trophic factor in the peripheral nervous system. Recently, proteins as well as mRNAs for both NGF and its receptor (NGF-R) have been detected in diverse areas in the central nervous system (CNS).
B, Lu +3 more
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Human Idiopathic Epiretinal Membranes Express NGF and NGF Receptors
Retina, 2008Glial cells and fibroblasts (FBs) play a key role in epiretinal membrane (ERM) development and progression. Myofibroblasts (myoFBs), arising from these cells, can lead to the hypertrophic scars and tissue contraction observed in ERMs. Nerve growth factor (NGF) and transforming growth factor-beta1 (TGF-beta1) play a crucial role in FB activities ...
Minchiotti, Simona +6 more
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