Results 301 to 310 of about 137,103 (391)

Circulating tumour cells (CTCs) in haematological malignancies: Advances in biology and clinical relevance with a focus on multiple myeloma

British Journal of Haematology, Volume 208, Issue 5, Page 1535-1550, May 2026.
Spatial heterogeneity limits the sensitivity of bone marrow biopsies, resulting in false‐negative findings. Circulating tumour cells (CTCs) provide a systemic, stratified monitoring approach, using flow cytometry for high tumour burden and EuroFlow or allele‐specific oligonucleotide PCR (ASO‐PCR) for minimal residual disease to enable early relapse ...
Chin‐Mu Hsu, Jui‐Feng Hsu, Jee‐Fu Huang, Yi‐Chang Liu   +3 more
wiley   +1 more source

Regulatory BC200 RNA promotes breast carcinogenesis by repressing BRCA1 gene expression. [PDF]

iScience
Berardi V, Muslimov IA, Sun D, Militello G, Premsrirut P, Tiedge H.   +5 more
europepmc   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons. [PDF]

Stem Cell Res Ther
Chanoumidou K, Zota I, Papadopoulou MA, Konstantinou C, Tsimpolis A, Tsagliotis E, Tziortziou M, Ntarntani K, Grünewald A, Lavigne MD, Gravanis A, Charalampopoulos I.   +11 more
europepmc   +1 more source

Nanotherapeutic Macrophage-Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis-Induced Lung Injury and Neurologic Damage. [PDF]

Adv Sci (Weinh)
Wang W, Hai Y, Lu X, Chen Y, Zhang B, Fan R, Dou J, Yan J, Fu S, Zhang W, Song J, Wei G.   +11 more
europepmc   +1 more source

Therapeutic potential of mesenchymal stem cells in peripheral nerve injuries in horses

Equine Veterinary Education, Volume 38, Issue 5, Page 252-260, May 2026.
Summary Peripheral nerve injuries (PNI) in horses represent a significant clinical challenge, frequently associated with functional deficits and reduced athletic performance. Conventional therapeutic approaches, primarily based on anti‐inflammatory treatments and rehabilitation, offer limited efficacy, driving the search for innovative alternatives. In
L. V. de Oliveira Ferreira, R. Martins Amorim   +1 more
wiley   +1 more source

Enuresis, ADHD and BDNF: A Narrative Review of the Hypothesized Interconnections and Potential Triplet Relationship. [PDF]

Brain Sci
Milioudi M, Stabouli S, Zafeiriou D, Vargiami E.   +3 more
europepmc   +1 more source

Animal Models of Hunner‐Type Interstitial Cystitis

International Journal of Urology, Volume 33, Issue 5, May 2026.
ABSTRACT Background Animal models are crucial for mechanistic studies and therapeutic development of human diseases. At present, the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic disease of the urinary bladder, remains undefined.
Yoshiyuki Akiyama, Yi Luo
wiley   +1 more source

Towards Mechanism‐Informed Treatments for Mental Health

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence   +27 more
wiley   +1 more source

TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells. [PDF]

Acta Neuropathol Commun
Manfreda L, Bortolozzi R, Mao D, Mariotto E, Viola G, Persano L, Rampazzo E.   +6 more
europepmc   +1 more source