Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation
– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond +4 more
wiley +1 more source
Long-term mechanical loading aggravates osteoarthritis through a pro-apoptotic inflammatory microenvironment. [PDF]
Shen S +10 more
europepmc +1 more source
Bridging the Gap Between Training and Reality: A Dental Scientist Trainee Perspective
ABSTRACT Dental schools stand at a crossroads. While research drives clinical innovation and improves patient outcomes, the pipeline for training future dentist‐scientists remains underdeveloped. Programs such as DDS/DMD‐PhD pathways and NIDCR‐supported initiatives aim to integrate scientific inquiry with clinical training.
Kazune Pax +8 more
wiley +1 more source
Should nasogastric enteral feeding become a standard escalation to reverse malnutrition in liver transplant candidates? [PDF]
Nassar A, Francoz C, Hobeika C.
europepmc +1 more source
Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration
Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal +7 more
wiley +1 more source
GPR3 is an immediate-early gene-like GPCR regulating CREB-dependent neuronal differentiation. [PDF]
Tanaka S +5 more
europepmc +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease. [PDF]
Varela V +15 more
europepmc +1 more source
Higher dietary magnesium intake is associated with lower risks of all‐cause, cardiovascular disease, and cancer mortality in individuals with chronic neck pain. The beneficial effects are partially mediated by reduced C‐reactive protein (CRP) levels. Optimizing dietary magnesium may improve long‐term prognosis in this population.
Renkun Zhao +13 more
wiley +1 more source

