Results 21 to 30 of about 239,741 (262)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Resistin Regulates Inflammation and Insulin Resistance in Humans via the Endocannabinoid System
ResearchResistin plays an important role in the pathophysiology of obesity-mediated insulin resistance in mice. However, the biology of resistin in humans is quite different from that in rodents. Therefore, the association between resistin and insulin resistance
Han-Mo Yang +11 more
doaj +1 more source
NeuroImage: Clinical, 2016 Background: The main focus of studies of individuals at ultra-high risk for psychosis (UHR) has been on identifying brain changes in those individuals who will develop psychosis. However, longitudinal studies have shown that up to half of UHR individuals
Sanne de Wit, MSc +7 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Engineering of Eu dopant segregation in colquiriite-type fluoride single crystal scintillators
AIP Advances, 2017 Colquiriite-type Eu-doped LiCaAlF6 and LiSrAlF6 (Eu:LiCAF and Eu:LiSAF) scintillator single crystals were grown using Al metal as a starting material to improve the Eu dopant segregation.
Yuui Yokota +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Investigation of the heterogeneity of cancer cells using single cell Ca2+ profiling
Cell Communication and SignalingBackground Calcium (Ca2+) is an essential second messenger that controls numerous cellular functions. Characteristics of intracellular Ca2+ oscillations define Ca2+ signatures representatives of the phenotype of a cell.
Amélie E. Bura +11 more
doaj +1 more source
Competência, 2016 O presente artigo apresenta uma síntese teórico-epistemológica resultante do constructo metodológico adotado no processo investigativo que contemplou discursos de docentes e discentes sobre práticas pedagógicas no âmbito da ...
Augusto Niche Teixeira +1 more
doaj +1 more source
KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state
Journal of Hematology & Oncology, 2021 Background Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance.
Jin-Woo Lee +16 more
doaj +1 more source