Results 71 to 80 of about 256,874 (388)
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Cells, 2023 Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world and are insidious in onset, chronic in nature, and yield significant disability and death.
Kenneth Maiese
doaj +1 more source
Distribution of enzymes cleaving pyridine nucleotides in animal tissues [PDF]
, 1957 A number of enzymes capable of splitting the pyridine nucleotides have been found in animal tissues. A portion of the DPNase (1) that hydrolyzes the nicotinamide ribose bond of DPN and TPN was reported in the microsomes of rat liver (1).
Jacobson, K. Bruce, Kaplan, Nathan O.
core +1 more source
Overview on topical 5-ALA photodynamic therapy use for non melanoma skin cancers [PDF]
, 2014 Ultraviolet radiation (UV) contributes to a variety of skin diseases including inflammation, degenerative aging, and cancer. Historically, humans have been exposed to UV radiation mainly through occupational exposure; recreational UV exposure, however ...
Bianchini, Daniela +7 more
core +3 more sources
Biosynthesis of Nicotinamide in Man.
Experimental Biology and Medicine, 1946 Summary(1) Four subjects subsisted for a period of 3 months on a diet of purified vitamin-free foods furnishing a daily intake of 1.5-2.0 mg nicotinamide. (2) There were no symptoms or signs of nicotinic acid deficiency observed during this period.(3) The urinary output expressed as N-methylnicotinamide chloride showed no reduction suggestive of ...
V. A. Najar +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Marine Drugs, 2018 Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl&ndash ...
Dong Hwee Son +10 more
doaj +1 more source
Determination of Nine Kinds of Vitamin B Components in Healthy Food Vitamin B Tablets by HPLC
Shipin gongye ke-ji, 2022 Objective: To establish a method for the determination of nine vitamin B components in vitamin B tablets by high performance liquid chromatography-diode array detector (HPLC-DAD). Method: Folic acid was ultrasonically extracted with 0.3% ammonia solution,
Wanqing TAN, Shuling WANG, Riqing GUAN
doaj +1 more source
Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]
, 2015 Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source