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The ionization constant of nicotinamide-adenine dinucleotide
Analytical Biochemistry, 1969The pKa of carefully purified oxidized nicotinamide adenine dinucleotide has been determined by potentiometric titration with sodium hydroxide at 25°. Values are reported for six ionic strengths up to 0.250. Extrapolation to zero ionic strength yields 3.88 ± 0.02 for the thermodynamic pKa.
C E, Moore, A L, Underwood
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Archives of Biochemistry and Biophysics, 1993
The thermodynamics of six reactions of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate is discussed both from the viewpoint of the chemical equations and the biochemical equations for these reactions. Tables of the standard enthalpies of formation and standard Gibbs energies of formation of species are presented and ...
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The thermodynamics of six reactions of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate is discussed both from the viewpoint of the chemical equations and the biochemical equations for these reactions. Tables of the standard enthalpies of formation and standard Gibbs energies of formation of species are presented and ...
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Psychopharmacological action of nicotinamide adenine dinucleotide
Psychopharmacologia, 1970The effect of nicotinamide adenine dinucleotide (NAD) upon the response rates in variable interval and Sidman Avoidance schedules was studied in rats. Bar pressing on the variable interval reinforcement schedule was significantly reduced during the 15 min following the administration of 10 mg/kg i.p.
T A, Layden, W R, McGrath, F D, Smith
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Electrochemical regeneration of nicotinamide adenine dinucleotide
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975Reduced nicotinamide adenine dinucleotide (NADH) has been characterized electrochemically by solid electrode voltammetry and controlled potential electrolysis. Photometric and enzymatic assay showed that enzymatically active nicotinamide adenine dinucleotide (NAD-+) could be regenerated electrolytically from its reduced form without the use of so ...
M, Aizawa, R W, Coughlin, M, Charles
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The biosynthesis of nicotinamide adenine dinucleotides in bacteria
2001The nicotinamide adenine dinucleotides (NAD, NADH, NADP, and NADPH) are essential cofactors in all living systems and function as hydride acceptors (NAD, NADP) and hydride donors (NADH, NADPH) in biochemical redox reactions. The six-step bacterial biosynthetic pathway begins with the oxidation of aspartate to iminosuccinic acid, which is then condensed
T P, Begley +4 more
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Journal of Chromatography A, 1985
Abstract The dimers of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) [(NAD)2 and (NADP)2, respectively[ were prepared electrolytically from NAD and NADP and analysed by several chromatographic techniques. Gel permeation chromatography on UltroPac columns was more convenient for the separation of dimers
J. Kova´rˇ +4 more
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Abstract The dimers of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) [(NAD)2 and (NADP)2, respectively[ were prepared electrolytically from NAD and NADP and analysed by several chromatographic techniques. Gel permeation chromatography on UltroPac columns was more convenient for the separation of dimers
J. Kova´rˇ +4 more
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Bioorganic & Medicinal Chemistry, 2009
Diadenosine disulfide (5) was reported to inhibit NAD kinase from Listeria monocytogenes and the crystal structure of the enzyme-inhibitor complex has been solved. We have synthesized tiazofurin adenosine disulfide (4) and the disulfide 5, and found that these compounds were moderate inhibitors of human NAD kinase (IC(50)=110 microM and IC(50)=87 ...
PETRELLI, Riccardo +14 more
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Diadenosine disulfide (5) was reported to inhibit NAD kinase from Listeria monocytogenes and the crystal structure of the enzyme-inhibitor complex has been solved. We have synthesized tiazofurin adenosine disulfide (4) and the disulfide 5, and found that these compounds were moderate inhibitors of human NAD kinase (IC(50)=110 microM and IC(50)=87 ...
PETRELLI, Riccardo +14 more
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Nicotinamide Adenine Dinucleotide: Beyond a Redox Coenzyme
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Nicotinamide Adenine Dinucleotide Based Therapeutics, Update
Current Medicinal Chemistry, 2015About 500 NAD (P)-dependent enzymes in the cell use NAD (P) as a cofactor or a substrate. This family of broadly diversified enzymes is crucial for maintaining homeostasis of all living organisms. The NAD binding domain of these enzymes is conserved and it was believed that NAD mimics would not be of therapeutic value due to lack of selectivity ...
Pankiewicz, K. W +3 more
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Nicotinamide-adenine dinucleotide pyrophosphatase of Cambaroides japonica
Biochimica et Biophysica Acta (BBA) - Enzymology, 1969Abstract 1. 1.The cleavage of NAD in crayfish hepatopancreas is catalyzed chiefly by a pyrophosphatase rather than by NAD glycohydrolase (EC 3.2.2.5). This fact was confirmed by the loss in the coenzyme function of NAD for yeast alcohol dehydrogenase without a significant concomitant loss in reactivity towards cyanide and the identification of ...
K, Yamaguchi, M, Shimoyama, I, Ueda
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