Results 61 to 70 of about 3,705 (161)

Bullous dermatoses secondary to anti-PD-L1 agents: a case report and review of the literature [PDF]

, 2019
Immune checkpoint inhibitors are used to treat numerous malignancies but may be associated with severe adverse events. Bullous dermatoses, chiefly bullous pemphigoid (BP), are potentially progressive adverse events that cause blistering skin lesions and ...
Choi, Jennifer N, Kosche, Cory, Owen, Joshua L, Sadowsky, Lauren M   +3 more
core  

The Combination of Pterocarpus marsupium Bark Extract, Pinus strobus Bark Extract, and Ascorbyl Tetraisopalmitate Inhibits Melanogenesis via Nicotinamide Nucleotide Transhydrogenase Activation

Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.
ABSTRACT Background Excessive ultraviolet exposure triggers skin pigment deposition, potentially leading to conditions such as melasma, freckles, and post‐inflammatory hyperpigmentation. The skin of individuals with these dermatological conditions exhibits reduced levels of nicotinamide nucleotide transhydrogenase (NNT).
Kejie Peng, Jian Mu, Yumeng Li, Zhangtie Wang, Yansong Peng, Tian Zhao, Yixuan Wang, Jing Wang, Baiyi Lu   +8 more
wiley   +1 more source

Fabrication of carbon pasta elektroda composition modified with nanobentonite and nano TiO2 for niacinamide detection sensor [PDF]

, 2023
Niacinamide is the amide form of vitamin B3, which is usually analyzed for concentration using UV-Vis Spectrophotometry, HPLC, and KLT. The development of niacinamide analysis methods using cyclic voltammetry has not been widely studied.
Anggraini Putri, Dhea, Setiarso, Pirim
core   +1 more source

Seasonal patterns in B‐vitamins and cobalamin co‐limitation in the Northwest Atlantic

Limnology and Oceanography, Volume 70, Issue 11, Page 3370-3385, November 2025.
Abstract B‐vitamins are important co‐enzymes that have long been hypothesized to play key roles in marine ecosystems. However, environmental measurements remain scarce, which limits our understanding of their potential impact. Here, we present mass spectrometry‐based measurements of B‐vitamins (B1, B2, B3, B5, B6, B12) and related vitamers along a ...
Catherine Bannon, Patrick L. White, Elden Rowland, Kiran J. More, Anna Gleason, Megan Roberts, Emmanuel Devred, Lindsay Beazley, Julie LaRoche, Erin M. Bertrand   +9 more
wiley   +1 more source

KT‐939: A Next‐Generation Human Tyrosinase Inhibitor With Superior Efficacy for the Safe Management of Hyperpigmentation

Journal of Cosmetic Dermatology, Volume 24, Issue 11, November 2025.
ABSTRACT Background Tyrosinase is the rate‐limiting enzyme in melanin biosynthesis, and its overactivity contributes to hyperpigmentation disorders. Existing tyrosinase inhibitors are often limited by poor potency against human tyrosinase (hTYR) or safety concerns. Aims To evaluate the inhibitory potency, safety, and multifunctional activity of KT‐939,
Xiaodan Hou, Yunhui Li, Qun Zhang, Honghua Yan, Xin Zhang, Yueying Yang, Xiang Cai, Jin Wang, Miaohua Ding, Dong Chen, Jie Chen, Youzhi Tong, Nina Mehta, Andy Goren   +13 more
wiley   +1 more source

皮膚の老化および抗老化に関する研究-新規メカニズムと生体機能性有効成分- [PDF]

, 2016
皮膚は人体最大の臓器であり、外部刺激や環境因子から生体内部を防御する上で重要な役割を担う。その皮膚老化は、外見に影響を与えるだけでなく、生体防御機構の乱れとして一連の病患を引き起こし、個人の生活の質（QOL; Quality of Life）の低下をもたらすことから、皮膚老化の進行を制御することがますます重要となっている。そこで、皮膚老化に大きく影響する要素を解明し、それぞれの要素の皮膚老化メカニズムを分子生物学的に解析することで ...
Xianghong Yan, 厳 向紅
core   +1 more source

Herbal Medicines for Weight Loss and Lipid Profile Improvement: A Scoping Review of Therapeutic Effects and Safety

Phytotherapy Research, Volume 39, Issue 10, Page 4870-4912, October 2025.
ABSTRACT The demand for alternative weight loss therapies has surged, with herbal medicinal products gaining popularity due to their natural origins, perceived safety, and accessibility. However, evidence regarding their therapeutic effects and safety for weight loss remains limited.
Marcela Forgerini, Geovana Schiavo, Osvaldo Galo Neto, Gabriela Barbosa Nascimento, Johnny Wallef Leite Martins, Patrícia de Carvalho Mastroianni   +5 more
wiley   +1 more source

A Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort

Aging Cell, Volume 24, Issue 10, October 2025.
A metabolite‐based score for short‐term unintentional weight loss was independently associated with mortality and mobility limitation risks in healthy older adults. It accounted for over 20% of the excess risk linked to unintentional weight loss, independent of lifestyle and medical history, suggesting a shared metabolic mechanism that remains ...
Shanshan Yao, Megan M. Marron, Samaneh Farsijani, Iva Miljkovic, George C. Tseng, Ravi V. Shah, Venkatesh L. Murthy, Anne B. Newman   +7 more
wiley   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Niacinamide and its impact on stratum corneum hydration and structure

Scientific Reports
Niacinamide (NIA) is widely used in skincare for its favorable safety profile, anti-aging effects, and proven clinical efficacy in treating various skin conditions.
Thomas Sjöberg, Andebrhan Fsahaye, Emelie J. Nilsson, Silvia Letasiova, Itedale Namro, Lene Visdal-Johnsen, Nina Hrapovic, Sandra Smiljanic, Christina Österlund, Johan Engblom, Sebastian Björklund   +10 more
doaj   +1 more source