Results 21 to 30 of about 7,641 (128)
Haematologica, 2012 Background Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear.Design and Methods Here, we evaluated ...
Lan Dan +7 more
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Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
Biomolecules, 2021 It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog vacor
Lars Jansen Sverkeli +3 more
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NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation
Frontiers in Oncology, 2020 Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively.
Valentina Audrito +2 more
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Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice
Frontiers in Pharmacology, 2023 Background: Acute kidney injury (AKI) induced by cisplatin remains a major impediment to the clinical application of cisplatin, necessitating urgent exploration for promising solutions.
Xinhui Liu +6 more
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Study on increase of nicotinamide mononucleotide yield by site-directed mutagenesis of nicotinamide phosphoribosyltransferase [PDF]
Zhongguo niangzaoNicotinamide phosphoribosyltransferase (NAMPT) was a key rate-limiting enzyme in the biosynthetic pathway of nicotinamide mononucleotide (NMN). In this study, the NAMPT gene derived from Comamonadaceae bacterium was heterologous expressed in Escherichia ...
DONG Ping, XU Yifan, HOU Ying, LUO Xuegang, ZHANG Lin, QIAO Changsheng
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Nature Communications, 2019 Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons +14 more
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Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.
PLoS Genetics, 2010 The essential coenzyme nicotinamide adenine dinucleotide (NAD+) plays important roles in metabolic reactions and cell regulation in all organisms. Bacteria, fungi, plants, and animals use different pathways to synthesize NAD+.
Huawen Lin, Alan L Kwan, Susan K Dutcher
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NAD+ metabolism controls inflammation during senescence
Molecular & Cellular Oncology, 2019 We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
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Crystal structure of human nicotinic acid phosphoribosyltransferase
FEBS Open Bio, 2015 Nicotinic acid phosphoribosyltransferase (EC 2.4.2.11) (NaPRTase) is the rate‐limiting enzyme in the three‐step Preiss–Handler pathway for the biosynthesis of NAD.
Ada Serena Marletta +5 more
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Endocrine Regulations, 2020 Objective. The aim of the present study was to investigate the effect of adipokine NAMPT (nicotinamide phosphoribosyltransferase) silencing on the expression of genes encoding IRS1 (insulin receptor substrate 1) and some other proliferation related ...
Tsymbal Daria O. +5 more
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