Results 151 to 160 of about 465,225 (381)

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel   +13 more
wiley   +1 more source

Workplace secondhand smoke exposure in the U.S. trucking industry. [PDF]

open access: yes, 2010
BackgroundAlthough the smoking rate in the United States is declining because of an increase of smoke-free laws, among blue-collar workers it remains higher than that among many other occupational groups.ObjectivesWe evaluated the factors influencing ...
Chiu, Yueh-Hsiu   +7 more
core  

Is it the nicotine or the tobacco?

open access: yesBulletin of the World Health Organization, 2000
Recentyearshaveseenagrowingrecognitionthatproductregulationiscriticaltodealingeffectivelywiththetobaccoepidemic.Itisalsonowwidelyrecognizedthat,thoughitisthenicotinethatcausesdependence, tobacco products (which can becharacterized as particularly ‘dirty’ drug deliverydevices)areresponsibleforthevastmajorityofthedamage to health.
openaire   +5 more sources

Dietary‐Driven Gene Expansion

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Gene duplication has been shown to drive molecular evolution, with dietary pressures expanding detoxification genes across species. In humans, CYP2D6 gene duplications enhance alkaloid and drug metabolism, reflecting ancient dietary adaptations. Similarly, tobacco‐feeding aphids amplify CYP6CY3 for nicotine and insecticide resistance, and as recently ...
Magnus Ingelman‐Sundberg
wiley   +1 more source

Effectively Regulating E-Cigarettes and Their Advertising—and the First Amendment [PDF]

open access: yes, 2015
If tobacco smoking did not exist in the United States, there would be no reason, from a public health perspective, to allow addictive, nicotine-containing e-cigarettes to be marketed and sold. Because e-cigarette use, by itself, is neither beneficial nor
Lindblom, Eric N
core   +1 more source

Small pouches, but high nicotine doses—nicotine delivery and acute effects after use of tobacco-free nicotine pouches

open access: yesFrontiers in Pharmacology
Tobacco-free nicotine pouches are new nicotine products for oral consumption. They can contain very high nicotine amounts that have not been addressed with clinical studies yet.
Nadja Mallock-Ohnesorg   +14 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li   +12 more
wiley   +1 more source

Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population

open access: yesEuropean Journal of Heart Failure, EarlyView.
Aims Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MACE and overall mortality in the general population in Germany.
Yvonne Huber   +15 more
wiley   +1 more source

Home - About - Disclaimer - Privacy