Results 111 to 120 of about 265,934 (241)

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice

Marine Drugs
Nicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects.
Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He, Ren-Bo Ding, Jiaolin Bao, Dongting Zhangsun, Sulan Luo   +7 more
doaj   +1 more source

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

International Journal of Cancer, EarlyView.
ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019.
Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug   +2 more
wiley   +1 more source

Gut Enterococcus faecium derived leucic acid mediates the antiobesity effect of dietary fiber

iMeta, EarlyView.
This study identified Enterococcus faecium as a gut bacterium with anti‐obesity activity, which alleviated adipocyte hypertrophy, dyslipidemia, and hepatic steatosis by converting leucine into leucic acid (LEA) to regulate mitochondrial oxidative phosphorylation.
Baifei Hu, Qianru Gao, Junmin Hui, Mengqiong Wang, Haiyan Gao, Kai Li, Junping Zheng, Zhe Dai, Songlin Liu, Hongtao Liu   +9 more
wiley   +1 more source

Measuring Treatment Effectiveness in Real‐World Substance Use Care: A Community‐Based Program Evaluation

Journal of Addictions &Offender Counseling, EarlyView.
ABSTRACT This study reports findings from a community‐based program evaluation examining treatment effectiveness in a real‐world outpatient substance use care setting. Using a within‐program pre–post design, changes in alcohol and drug use were assessed among clients receiving intensive outpatient services.
Jessie A. Brown, Taryn M. Akgul, Todd F. Lewis, Patti Senn   +3 more
wiley   +1 more source

Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach

, 2013
International audienceTobacco produces an impressive burden of disease resulting in premature death in half of users. Despite effective smoking cessation medications (nicotine replacement therapies, bupropion and varenicline), there is a very high rate ...
Le Foll, Bernard, Vemuri, Kiran, Pushparaj, Abhiram, Makriyannis, Alexandros, Forget, Benoit, Pryslawsky, Yaroslaw, Trigo, Jose, M.   +6 more
core   +1 more source

Taking Jobs and Doing Harm

Journal of Applied Philosophy, EarlyView.
ABSTRACT In popular discourse and in the philosophical literature there is almost no reflection on the morality of doing harm in the context of doing one's job. To the contrary, workers are valorised simply for having a job, and typically individual workers are spared from blame, even when they cause significant harm as part of their job.
Theron Pummer, Benjamin Sachs‐Cobbe
wiley   +1 more source

Developmental and Behavioral Effects of Arsenobetaine in Zebrafish (Danio rerio)

Journal of Applied Toxicology, EarlyView.
ABSTRACT Arsenobetaine (AsB) is a prevalent organoarsenical in aquatic environments and is generally regarded as nontoxic. Despite its widespread occurrence, the developmental and neurobehavioral toxicity of AsB has not been systematically investigated.
Sravan Kumar Putnala, Prerita Sharma, Prannav Jain, Samira Leila Baldin, Owen Luo, A. K. M. Munzurul Hasan, Md Helal Uddin, Mahesh Rachamalla, Som Niyogi   +8 more
wiley   +1 more source

E-cigarettes for the management of nicotine addiction

, 2016
Oliver Knight-West, Christopher Bullen The National Institute for Health Innovation, School of Population Health, The University of Auckland, Auckland, New Zealand Abstract: In this review, we discuss current evidence on electronic cigarettes (ECs),
Knight-West O, Bullen C
core  

Nicotine addiction: More than just dopamine. [PDF]

Curr Opin Neurobiol, 2023
Kim K, Picciotto MR.
europepmc   +1 more source

Acute Effects of Smoking and Vaping on Markers of Vascular Function via Quantitative MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background E‐cigarettes contribute to endothelial dysfunction, a known cause of systemic atherosclerotic disease that cannot be adequately characterized by a single physiological parameter measured at a single vascular bed. Purpose/Hypothesis Quantify and compare acute effects of smoking or vaping with tobacco cigarettes (t‐cigs), nicotinized ...
Marianne Nabbout, Mahdie Hosseini, Harris Quach, Michael C. Langham, Alessandra S. Caporale, Wensheng Guo, Kathryn Jaroszynski, Frank T. Leone, Andrew A. Strasser, Felix W. Wehrli   +9 more
wiley   +1 more source