Results 71 to 80 of about 102,363 (294)
Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Advanced Science, EarlyView.Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang +4 more
wiley +1 more source
An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. [PDF]
, 2018 Tobacco use disorder is the leading cause of disease and preventable death worldwide, but current medications that are based on pharmacodynamics have low efficacy.
George, Olivier +4 more
core +1 more source
DSM-5 criteria for substance use disorders: recommendations and rationale. [PDF]
, 2013 Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen.
Auriacombe, Marc +11 more
core +1 more source
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source
Advanced Energy Materials, EarlyView.ABSTRACT Sustainable hydrogen generation through water splitting is key to realizing a future hydrogen economy. In this study, we achieved molecular‐level control over self‐assembled supramolecular complexes of cyanuric acid and 3‐amino 1,2,4 triazole (AT) monomers. This was coupled with molten‐salt‐assisted thermal polymerization in a eutectic mixture
Nithinraj Panangattu Dharmarajan +13 more
wiley +1 more source
Nicotine Dependence as a Mediator of Project EX's Effects to Reduce Tobacco Use in Scholars. [PDF]
, 2016 In Spain, 44% of 14-18-year-olds have smoked, and 12.5% have smoked cigarettes in the last 30 days. Nicotine is one of the most addictive substances, and can lead to serious addiction in adulthood with adverse consequences to one's health. School plays a
Espada, José P +4 more
core +2 more sources
Clinical Neglect of Nicotine Dependence [PDF]
Australian & New Zealand Journal of Psychiatry, 2005 ‘From the first beginning of our knowledge of man, we find him consuming substances of no nutritive value, but taken for the sole purpose of producing for a certain time a feeling of contentment, ease and comfort’, wrote the famous German pharmacologist Lewis Lewin in his highly cited text Phantastica, narcotic and stimulating drugs [1].
openaire +2 more sources
Advanced Energy Materials, EarlyView.We identify two decisive levers for SAM interfaces: molecular design (carboxylic acid‐based, phosphonic acid, other anchoring chemistries, and polymeric SAMs) and mixing routes (co‐assembly, in situ assembly, pre‐ and post‐treatment). Coordinated tuning of headgroups and assembly pathways optimises energy alignment and film formation, suppresses ...
Jiaxu Zhang, Bochun Kang, Feng Yan
wiley +1 more source
Rash impulsiveness and negative mood, but not alexithymia or reward sensitivity, differentiate young to middle-aged chronic daily smokers from never-smokers [PDF]
, 2017 Given the well-established associations of the personality traits alexithymia, impulsivity, and reward sensitivity with problematic use of a variety of substances, including alcohol and cannabis, the present study sought to determine whether daily ...
Bremner, Monique +3 more
core +1 more source
American Journal of Community Psychology, EarlyView.Abstract Community action focused on sociocultural and environmental influences to prevent alcohol and other drug (AOD) use and related harms is a global priority. Despite this recognition, understanding of effective community‐level approaches is limited.
Peter Gates, Andrea Zocco, Sara Farnbach
wiley +1 more source