Results 91 to 100 of about 102,363 (294)

Editorial Commentary: Tobacco or Not—All Nicotine Products Negatively Impact Rotator Cuff Surgery

Arthroscopy, EarlyView.
Abstract Rotator cuff repair is one of the most common elective orthopaedic surgeries performed; however, failure rates have been reported to range from 10% to 94% depending on the tear characteristics and other patient risk factors. One of the most common risk factors for failure is tobacco use.
Justin J. Ernat
wiley   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization [PDF]

, 2004
The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic effects of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic subunits containing a single point mutation, Leu^(9′) → Ala^(9′) in the ...
Collins, Allan C., Deshpande, Purnima, Labarca, Cesar, Lester, Henry A., Marks, Michael J., McKinney, Sheri L., Nashmi, Raad, Schwarz, Johannes, Tapper, Andrew R., Whiteaker, Paul   +9 more
core  

Treating substance abuse is not enough: Comorbidities in consecutively admitted female prisoners [PDF]

, 2015
Publisher Copyright: © 2015 Elsevier Ltd.Introduction: Several studies have pointed to high rates of substance use disorders among female prisoners. The present study aimed to assess comorbidities of substance use disorders with other mental disorders in
Adrian P. Mundt, Andreas Ströhle, Arntz, Binswanger, Brooke, Burling, Butler, Clarke, Compton, Daniel, Driessen, Dudeck, Fazel, Fazel, Fazel, First, Fydrich, Goldner, Gunter, Heatherton, Jacobi, Jan Mir, Johnson, Jordan, Maden, Mundt, Mundt, Norbert Konrad, Payne, Priebe, Schenk, Sheehan, Sheehan, Sinja Kastner, Steadman, Stefan Priebe, UNESCO Institute for Statistics, van den Bergh, van Emmerik-van Oortmerssen, von Schönfeld, Walmsley, Wright   +41 more
core   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, EarlyView.
Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

The Brief Symptom Inventory-9 (BSI-9): Development and validation in a German general population sample

BMC Psychology
Background The Brief Symptom Inventory-18 (BSI-18) is a self-report questionnaire with three subscales, somatisation, anxiety, and depression, based on longer measures of distress.
C. MacDonald, K. Brophy, A. Coroiu, Elmar Braehler, A. Körner   +4 more
doaj   +1 more source

Drinking in the Dark: Voluntary Co-consumption of Nicotine and Alcohol for Binge-like Drinking Behavior in Mice [PDF]

, 2019
Alcohol and nicotine are two of the most commonly abused drugs across the United States. Given the high rates of comorbidity, it remains a pressing public health concern to determine how the two drugs interact within the CNS, and how this impacts ...
Benson, Katherine
core   +1 more source

Nicotine is more addictive, not more cognitively therapeutic in a neurodevelopmental model of schizophrenia produced by neonatal ventral hippocampal lesions [PDF]

, 2013
Nicotine dependence is the leading cause of death in the United States. However, research on high rates of nicotine use in mental illness has primarily explained this co-morbidity as reflecting nicotine's therapeutic benefits, especially for cognitive ...
Berg, Sarah A., Chambers, R. Andrew, Cooley, Benjamin S., Engleman, Eric A., Sentir, Alena M.   +4 more
core   +1 more source