Results 101 to 110 of about 77,143 (337)

The Oncogenic Functions of Nicotinic Acetylcholine Receptors [PDF]

Journal of Oncology, 2016
Nicotinic acetylcholine receptors (nAChRs) are ion channels that are expressed in the cell membrane of all mammalian cells, including cancer cells. Recent findings suggest that nAChRs not only mediate nicotine addiction in the brain but also contribute to the development and progression of cancers directly induced by nicotine and its derived ...
openaire   +2 more sources

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation

Frontiers in Neuroscience
Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. The cholinergic neurotransmitter system drives attention to salient stimuli such as stressors, and aids in orchestrating the ...
Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa   +3 more
doaj   +1 more source

Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability [PDF]

arXiv, 2017
Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle tracking, mean-squared displacement (MSD), turning angle, ergodicity, and clustering analyses to ...
arxiv  

A spatial covariance (123)I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease [PDF]

, 2016
Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown.
Colloby, Sean J., Field, Robert H., O'Brien, John T., Taylor, John-Paul, Wyper, David J.   +4 more
core   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

A computational insight of the improved nicotine binding with ACE2-SARS-CoV-2 complex with its clinical impact [PDF]

arXiv, 2020
Smokers being witnessed with the mild adverse clinical symptoms of SARS-CoV-2, the in-silico study is intended to explore the effect of nicotine binding to the soluble angiotensin converting enzyme II (ACE2) receptor with or without SARS-CoV-2 binding.
arxiv  

Identification of critical residues in loop E in the 5-HT(3AS)R binding site [PDF]

, 2002
BACKGROUND: The serotonin type 3 receptor (5-HT(3)R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity.
Joshi, Prasad R, Muthalagi, Mani, Schulte, Marvin K, Venkatachalan, Srinivasan P, Venkataraman, Padmavati   +4 more
core   +3 more sources

Evaluation of GS‐omega/kappa‐Hxtx‐Hv1a and Bt toxins against Bt‐resistant and ‐susceptible strains of Helicoverpa zea (Boddie) and Spodoptera frugiperda (J.E. Smith)

Pest Management Science, Volume 81, Issue 7, Page 3565-3572, July 2025.
The addition of 10 μg cm−2 of Cry1Ac to the surface of GS‐omega/kappa‐Hxtx‐Hv1a (ω/κ‐Hv1a) incorporated diet can significantly increase the mortality of Cry‐resistant Helicoverpa zea compared to diets without the Cry1Ac toxin. Abstract BACKGROUND Helicoverpa zea and Spodoptera frugiperda are destructive insect pests of cotton and corn.
Simeon Ross, Fei Yang, José C. Santiago‐González, Heba Abdelgaffar, Dawson D. Kerns, Juan Luis Jurat‐Fuentes, Xiaocun Sun, Dayna Collett, David L. Kerns   +8 more
wiley   +1 more source

Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]

arXiv, 2018
Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv